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Correlation of tumor-associated macrophage density and proportion of m2 subtypes with the pathological stage of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1878-1889页

作者： Fouzia Fazal muhammad Arsalan Khan Sumayya Shawana Rahma Rashid muhammed mubarak Department of Pathology Jinnah Medical and Dental CollegeKarachi 74800SindhPakistan Department of General Surgery Sindh Institute of Urology&Transplantation(SIUT)Karachi 74200SindhPakistan Department of Pathology Bahria University of Health SciencesKarachi 74400SindhPakistan Department of Pathology SIUTKarachi 74200SindhPakistan

BACKGROUND Colorectal cancer(CRC)is a prevalent global malignancy with complex prognostic ***-associated macrophages(TAms)have shown paradoxical associations with CRC survival,particularly concerning the m2 *** We aimed to establish a simplified protocol for quantifying m2-like TAms and explore their correlation with clinicopathological *** A cross-sectional study included histopathological assessment of paraffinembedded tissue blocks obtained from 43 CRC *** CD68 and CD163 immunohistochemistry,we quantified TAms in tumor stroma and front,focusing on m2 ***,histopathological,and clinical parameters were *** TAm density was significantly higher at the tumor front,with the m2 proportion three times greater in both *** tumor front had a higher m2 proportion,which correlated significantly with advanced tumor stage(P=0.04),pathological nodal involvement(P=0.04),and lymphovascular invasion(LVI,P=0.01).However,no significant association was found between the m2 proportion in the tumor stroma and clinicopathological *** Our study introduces a simplified protocol for quantifying m2-like TAms in CRC tissue *** demonstrated a significant correlation between an increased m2 proportion at the tumor front and advanced tumor stage,nodal involvement,and *** suggests that m2-like TAms might serve as potential indicators of disease progression in CRC,warranting further investigation and potential clinical application.

关键词： Colorectal cancer macrophages Tumor stroma m2 subset Tumor front Tumor stage Lymphovascular invasion Prognosis Tumor-associated macrophages Immunohistochemistry

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