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m2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy

Journal of materials Science & Technology 2021年第22期81卷 77-87页

作者： Wenshen Wang Fenfen Li Shibo Li Yi Hu mengran Xu Yuanyuan Zhang muhammad Imran Khan Shaozhen Wang min Wu Weiping Ding Bensheng Qiu National Lab for Physical Sciences at the microscale and the Centers for Biomedical Engineering University of Science and Technology of ChinaHefei230027China The First Affiliated Hospital of Anhui medical University Hefei230022China

Tumor-associated macrophages(TAms)play an important role in tumor development and *** particular,m2 TAms can promote tumor growth by facilitating tumor progression and malignant *** targeted elimination of m2 TAms to inhibit tumor progression is of great significance for cancer *** oxide nanoparticles based magnetic hyperthermia therapy(mHT)is a classical approach to destroy tumor tissue with deep penetration *** this study,we developed a typical m2 macrophage-targeted peptide(m2pep)functionalized superparamagnetic iron oxide nanoparticle(SPIO)for magnetic resonance imaging(mRI)-guided mHT in an orthotopic breast cancer mouse *** obtained multifunctional SPIO-m2pep with a hydrodynamic diameter of 20 nm showed efficient targeting capability,high transverse relaxivity(149 mm^(-1) s^(-1))and satisfactory magnetic hyperthermia performance in *** vivo studies demonstrated that the SPIO-m2pep based mRI can monitor the distribution of nanoparticles in tumor and indicate the suitable timing for *** m2 macrophage-targeted mHT significantly reduced the tumor volume and the population of pro-tumoral m2 TAms in *** addition,the SPIO-m2pep based mHT can remodel the tumor immune microenvironment(TImE).The multifunctional SPIO-m2pep with m2 macrophage-targeting ability,high magnetic hyperthermia efficiency,mR imaging capability and effective role in remodeling the TImE hold great potential to improve clinical cancer therapy outcomes.

关键词： m2 macrophages-targeted peptide Iron oxide nanoparticles magnetic resonance imaging magnetic hyperthermia therapy Tumor immune microenvironment

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