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Soxllb regulates the migration and fate determination of müller glia-derived progenitors during retina regeneration in zebrafish

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Neural Regeneration Research 2023年第2期18卷 445-450页

作者： Kaida Song Zihao Lin Lining Cao Bowen Lu Yuxi Chen Shuqiang Zhang Jianfeng Lu Hui Xu Key Lab of Neuroregeneration of Jiangsu and ministry of Education Co-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina

The transcription factor Sox11 plays important roles in retinal neurogenesis during vertebrate eye ***,its function in retina regeneration remains *** we report that Sox11 b,a zebrafish Sox11 homolog,regulates the migration and fate determination of müller glia-derived progenitors(mGPCs)in an adult zebrafish model of mechanical retinal *** a stab injury,the expression of Sox11 b was induced in proliferating mGPCs in the ***11 b knockdown did not affect mGPC formation at 4 days post-injury,although the nuclear morphology and subsequent radial migration of mGPCs were alte *** 7 days post-injury,Sox11 b knockdown res ulted in an increased proportion of mGPCs in the inner retina and a decreased propo rtion of mGPCs in the outer nuclear layer,compared with ***,Sox11 b knockdown led to reduced photoreceptor regeneration,while it increased the numbe rs of newborn amacrines and retinal ganglion ***,quantitative polymerase chain reaction analysis revealed that Sox11 b regulated the expression of Notch signaling components in the retina,and Notch inhibition partially recapitulated the Sox11 b knockdown phenotype,indicating that Notch signaling functions downstream of Sox11 *** findings imply that Sox11 b plays key roles in mGPC migration and fate determination during retina regeneration in zebrafish,which may have critical im plications for future explorations of retinal repair in mammals.

关键词： cell migration fate determination müllerglia müller glia-derived progenitor Notch signaling photoreceptor retina regeneration Sox11 transcription factor zebrafish

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