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Tumor lysis Syndrome in the Course of Burkitt Lymphoma Revealed by Medullar Compression

Open Journal of Modern Neurosurgery 2019年第4期9卷 429-435页

作者： L. Boukassa S. B. Kinata Bambino O. B. Ngackosso K. Mavoungou Biatsi H. B. Ekouele-Mbaki P. Mawanza Department of Surgery Division of Neurosurgery Brazzaville Academic Hospital Brazzaville Republic of Congo Department of Anesthesia-Reanimation Brazzaville Academic Hospital Brazzaville Republic of Congo

Background: Tumor lysis syndrome is unknown to many neurosurgical teams. A dreaded complication, especially in the course of hematological malignancies, like it was the case in two of our patients operated for spinal cord compression by Burkitt’s lymphoma. Objectives: To describe the clinical and biological presentation of this potentially fatal complication, which can be improved by early preventive or curative treatments. Case Reports: Patient 1: A 49-year-old woman was admitted for vertebral and intercostal pain and paraparesis. Myelography revealed epidural medullary compression at the 7th thoracic vertebrae (Th7) level. Patient 2: A 67-year-old woman was admitted for cervico-thoracic pain and paraparesis. MRI showed posterior epidural medullary compression between the 1st thoracic vertebrae (Th1) and 5th thoracic vertebrae (Th5). In both cases, an urgent decompressive laminectomy was performed. They had also received postoperative corticosteroid therapy. The multi-visceral failure occurred on the 1st day (D1) and 3rd day (D3) postoperatively, respectively. In the absence of adequate management, the outcome was fatal for the two patients respectively at D3 and D5 postoperatively. This syndrome was retained in the presence of glucocorticoid (triggering factor) and the histological result in favor of Burkitt lymphoma (target disease). Conclusion: Malignant hemopathies is a common cause of spinal cord compressions. From these two cases, the importance of biological and clinical surveillance emerges, with patients requiring urgent management for radiculo-medullar tumor compression.

关键词： Tumor lysis Syndrome Spinal Cord Compression Burkitt Lymphoma

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Tumor lysis syndrome: A clinical review

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World Journal of Critical Care Medicine 2015年第2期4卷 130-138页

作者： Aibek E Mirrakhimov Prakruthi Voore Maliha Khan Alaa M Ali Department of Internal Medicine Saint Joseph Hospital

Tumor lysis syndrome is an oncometabolic emergency resulting from rapid cell death. Tumor lysis syndrome can occur as a consequence of tumor targeted therapy or spontaneously. Clinicians should stratify every hospitalized cancer patient and especially those receiving chemotherapy for the risk of tumor lysis syndrome. Several aspects of prevention include adequate hydration, use of uric acid lowering therapies, use of phosphate binders and minimization of potassium intake. Patients at high risk for the development of tumor lysis syndrome should be monitored in the intensive care unit. Established tumor lysis syndrome should be treated in the intensive care unit by aggressive hydration, possible use of loop diuretics, possible use of phosphate binders,use of uric acid lowering agents and dialysis in refractory cases.

关键词： Cancer Arrhythmia Seizure disorder Tumor lysis syndrome Acute kidney injury

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Bacterial lysis of Microalgal Cells

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Journal of Sustainable Bioenergy Systems 2014年第4期4卷 243-248页

作者： Meng Wang Wenqiao Yuan Department of Biological and Agricultural Engineering North Carolina State University Raleigh USA

This short communication reports a pioneering research of using bacteria for simultaneous algal cell disruption and cell wall/membrane utilization. Microalgae are regarded as one of the most promising feedstock that can potentially address the twin challenges of energy security and environmental protection due to their fast growth rate, high lipid content and CO2 biofixation capabilities. However, different from their terrestrial oil crops, the extracellular coverings of algae vary significantly, ranging from multiple layers of elaborate scales to highly mineralized coats to complex cell walls consisting of structural fibrils enmeshed in complex matrices. These strong cellular walls and membranes are resistant to disintegration, which makes lipid extraction from microalgae difficult. A bacteria-assisted algal cell disruption and lipid extraction method was studied here. The bacteria Sagittula stellata showed strong algicidal activity against two microalgae, Nannochloropsis oculata and Dunaliella salina. The algicidal rate reached 64.7% on N. oculata and 52.4% on D. salina in six days. A decrease in chlorophyll-a fluorescence density of both algae and bacteria addition was also observed. After 6-day treatment by S. stellata, hexane-extracted crude lipid contents increased from 32.9% to 45.7% and from 19.6% to 36.4% for N. oculata and D. salina, respectively, when compared with no bacterial addition. The preliminary results concluded that S. stellata was effective in the lysis of microalgal cells for effective lipid recovery.

关键词： Microalgae Cell lysis Lipid Extraction

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Successful prevention of tumor lysis syndrome using recombinant urate oxidase in patient with metastasic and bulky prostate rhabdomyosarcoma

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Case Reports in Clinical Medicine 2014年第1期3卷 18-22页

作者： Atsuko Watanabe Ryuhei Tanaka Department of Pediatric Oncology/Hematology International Medical Center Saitama Medical University Hidaka Japan Department of Pediatrics Kasumigaura Medical Center Tsuchiura Japan Department of Pediatric Oncology/Hematology International Medical Center Saitama Medical University Hidaka Japan

Tumor lysis syndrome (TLS) is a life-threatening oncological emergency that frequently occurs in patients with hematological malignancies. It is becoming more common in patients with solid tumors because of advances in molecular targeted therapies. Recombinant urate oxidase (rUO) is effective at preventing and treating hyperuricemia, but clinicians who treat adult patients with solid tumors are generally not aware of this. In addition, the treatment guidelines for TLS do not include indications for rUO treatment for chemosensitive sarcoma. We report an adolescent case of metastatic rhabdomyosarcoma (RMS), in which clinical TLS was successfully prevented using rUO. A 16-year-old Japanese male suffered from urinary retention and bone pain and was diagnosed with prostate RMS combined with multiple bone metastases and bone marrow involvement. He was judged to be at high risk of clinical TLS because his prostate tumor was bulky and he displayed laboratory TLS. rUO was administered during chemotherapy. Soon after the initiation of chemotherapy, his disseminated intravascular coagulation (DIC) got worse, and his lactate dehydrogenase (LDH) level was elevated due to tumor lysis. However, his serum uric acid levels remained low, and he was prevented from falling into acute renal failure. The planned regimen was successfully completed without life-threatening complications, and the patient achieved a complete response after 2 courses of chemotherapy. The international TLS consensus panel developed recommendations for TLS prophylaxis, but did not define the TLS risk classification of RMS. We recommend that RMS should be treated like neuroblastoma because it grows rapidly and is highly chemosensitive. Our patient was considered to be indicated for rUO because he displayed urinary retention, DIC, and laboratory TLS before chemotherapy. These features might be useful as indications for rUO therapy, which can safely support chemotherapy.

关键词： Tumor lysis Syndrome Recombinant Urate Oxidase Rhabdomyosarcoma

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Take actions to bridge the gaps between China and other countries:in the aspect of markers of mineral bone disease from China Dialysis Outcomes and Practice Patterns Study phase 5

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Chinese Medical Journal 2019年第23期132卷 2773-2774页

作者： Li Zhou Ping Fu Division of Nephrology Kidney Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041China

Chinese National Renal Data System111 is the first national database for Chinese hemodialysis(HD)population,but unfortunately,data of monitoring frequency of laboratory markers were not well recorded,and therapeutic information was not timely *** China Dialysis Outcomes and Practice Patterns Study(DOPPS)is a representative of Chinese HD patients with close following,as compared with data of other countries.

关键词： Pattern lysis comes

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Molecular exposition of broad‑spectrum antibacterial efficacy by p‑coumaric acid from an edible mushroom Termitomyces heimii:in vitro and in silico approach

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 750-764页

作者： Krishanu Singha Amrita Banerjee Arijit Jana Poushali Bandyopadhyay Smarajit Maiti Bikas Ranjan Pati Pradeep Kumar Das Mohapatra Department of Microbiology Vidyasagar UniversityMidnaporeWest Bengal 721102India Department of Biotechnology Oriental Institute of Science and TechnologyMidnaporeWest Bengal 721102India Department of Chemical Engineering IIT RoorkeeUttarakhand 247667India Department of Microbiology Raiganj UniversityRaiganjWest Bengal 733134India

P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer *** with these,the present work has been conducted to study the antibacterial activity of p-coumaric *** could be used to control broad-spectrum microbiome-based inflammation or in cancer *** analysis of methanolic extract from the mushroom Termitomyces heimii has exhibited a rich fraction of p-coumaric acid(p-CA),which in the pure form showed significant bactericidal *** predict the molecular interactions associated with the bactericidal mechanism of p-CA,the transmembrane protein sequences of Staphylococcus aureus and Escherichia coli were retrieved from the IMG–JGI database,screened and then aligned using Clustal X2 and PHYLIP 3.69 *** common sequences were subjected to tertiary structure prediction using Phyre2 server,followed by quality assessment through the Ramachandran ***,the 3D molecular structure of p-CA was downloaded from PubChem and docked with the selected tertiary structures using Patchdock and showed higher affinity towards 12 common transmembrane protein structures,amongst which CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyl transferase(PgsA)exhibited best dock-ing with p-CA on the basis of ACE value(–249 kcal/mol).This fact revealed that p-CA can block the normal functioning of membrane-bound enzyme PgsA,consequently leading to the interruption in the synthesis and recycling of an essential membrane component phosphatidylglycerol(PG),resulting in membrane disruption followed by cell ***,for the first time we reported the molecular insights and fundamental biochemical events underlying the bactericidal action by p-CA,to explore new perspective to combat multidrug-resistant bacteria.

关键词： p-Coumaric acid Bactericidal Docking ACE value PgsA lysis

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INVERSION OF STRIKE-SLIP MOVEMENTS ALONG THE YARLUNG ZANGBO SUTURE ZONE, TIBET

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地学前缘 2000年第S1期7卷 111-112页

作者： Kobayashi Kenta 1, Matsuoka Atsushi 2, Yang Qun 3, Nagahashi Toru 1, Takei Masahiko 1, Zeng Qinggao 4,Wang Yujin 3 (1 Graduate School of Science and Technology, Niigata University, Niigata 950\|2181, Japan 2 Department of Geology, Niigata Uni

Meso\| and microstructural characteristics of cataclastic fault rocks developed in the Xialu chert are described. The Xialu chert represents pelagic and deep marine sediments (Middle Jurassic—Lower Cretaceous), and occupies the southern marginal part of the E—W trending Yarlung Zangbo suture zone. The apparent total thickness of siliceous deposits exceeds 1km. The current study is concentrated along the two measured sections, Xialu\|E and Xialu\|W. The Xialu\|E section is composed mainly of red chert associated with reddish purple siliceous mudstone and greenish gray mudstone. The beds steeply dip north or south. The 45m section studied is divided into three units (chert unit, chert\|siliceous mudstone unit, and melange unit from north to south). They are in fault contact with each other. In the southern half of the chert unit and the northernmost of the chert\|siliceous mudstone unit, a 15m thick cohesive cataclasite zone can be defined. The cataclasites are composed of chert fragments in a fine grained matrix, and deformed with jigsaw puzzle structures. The chert\|siliceous mudstone unit is made up of four slabs of chert\|siliceous mudstone sequence. Mesoscopic duplex zones in thickness from 1 to 3m are recognized at slab boundaries. Flat and ramp structure and associated P foliations, R1 shears, Y surfaces are developed. Shear spacing range from 1 to 10cm. The slip senses are dextral strike\|slip movement along these duplex zones. The cataclasite zone is cut by the duplex zone along the southern boundary.

关键词： Tibet Yarlung Zangbo Suture Zone Xialu chert structural ana lysis fault rocks strike slip inversion

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儿童重度先天马蹄内翻足手术切口的改进

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中华小儿外科杂志 1987年第3期9卷 168-169页

作者：王世清张铁平卫生部1984年援索医疗队

本文介绍了儿童重度先天性马蹄内翻足手术切口的改进.采用新切口手术的患儿15例,其中双侧2例,行17次手术,除2次手术术后游离皮片大部未成活,需再次植皮外,余均达到一次手术彻底矫正畸形.

关键词：儿童重度先天马蹄内翻足手术切口改进 Treatment Tissue lysis Soft 先天性马蹄内翻足游离皮片一次手术矫正畸形术术后植皮患儿成活

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Bacteriophage secondary infection

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Virologica Sinica 2015年第1期30卷 3-10页

作者： Stephen T Abedon Department of Microbiology the Ohio State University OH 44906 USA

Phages are credited with having been first described in what we now, officially, are commemorating as the 100 th anniversary of their discovery. Those one-hundred years of phage history have not been lacking in excitement, controversy, and occasional convolution. One such complication is the concept of secondary infection, which can take on multiple forms with myriad consequences. The terms secondary infection and secondary adsorption, for example, can be used almost synonymously to describe virion interaction with already phage-infected bacteria, and which can result in what are described as superinfection exclusion or superinfection immunity. The phrase secondary infection also may be used equivalently to superinfection or coinfection, with each of these terms borrowed from medical microbiology, and can result in genetic exchange between phages, phage-on-phage parasitism, and various partial reductions in phage productivity that have been termed mutual exclusion, partial exclusion, or the depressor effect. Alternatively, and drawing from epidemiology, secondary infection has been used to describe phage population growth as that can occur during active phage therapy as well as upon phage contamination of industrial ferments. Here primary infections represent initial bacterial population exposure to phages while consequent phage replication can lead to additional, that is, secondary infections of what otherwise are not yet phage-infected bacteria. Here I explore the varying meanings and resultant ambiguity that has been associated with the term secondary infection. I suggest in particular that secondary infection, as distinctly different phenomena, can in multiple ways influence the success of phage-mediated biocontrol of bacteria, also known as, phage therapy.

关键词： lysis from without lysis inhibition coinfection parallel secondary infection phage therapy pharmacology serial secondary infection superinfection

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Virally-Mediated Versus Grazer-Induced Mortality Rates in a Warm-Temperate Inverse Estuary (Spencer Gulf, South Australia)

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Open Journal of Marine Science 2014年第4期4卷 257-278页

作者： Laurent Seuront Mark Doubell Paul Van Ruth CNRS UMR 8187 LOG Wimereux France School of Biological Sciences Flinders University Adelaide Australia Aquatic Sciences South Australian Research and Development Institute West Beach Australia

We investigated the seasonal dynamics of flow cytometrically-defined populations of viruses, heterotrophic bacteria, and the picoeukaryotic and prokaryotic phytoplankton at three sites in the temperate oligotrophic inverse estuary of Spencer Gulf (South Australia). We consistently identified two sub-populations of viruses, three sub-populations of heterotrophic bacteria, one population of picoeukaryotic phytoplankton and two populations of prokaryotic phytoplankton (cyanobacteria Prochlorococcus and Synechococcus). Both the cytometric community composition and the abundance of viruses, heterotrophic bacteria and both prokaryotic (Synechococcus and Prochlorococcus) and eukaryotic picophytoplankton were consistent with previous observations conducted in South Australian continental shelf waters. Noticeably LDNA bacteria (i.e. inactive or dormant cells) were consistently significantly the most abundant group of heterotrophic bacteria (totaling from 29% to 68% of total bacterial abundance) and were up to 10-fold more abundant than that previously reported in South Australian continental shelf waters, including the nearby Saint Vincent Gulf. These results suggest an overall low activity of the microbial community, and are consistent with previous evidence that LDNA cells may play a greater role in heterotrophic processes than HDNA cells in oligotrophic waters. In an attempt to further assess the qualitative and quantitative nature of the mortality of these organisms, we used a specific dilution assay to assess the relative contribution of viruses and microzooplankton grazers to the mortality rates of heterotrophic bacteria, and picoeukaryotic and prokaryotic phytoplankton. We consistently reported site-specific, population specific and sea-son-specific viral lysis and grazing rates of heterotrophic bacteria and the picoeukaryotic and prokaryotic (cyanobacteria Prochlorococcus and Synechococcus) phytoplankton across sites and seasons. Specifically, both viral lysis and mi

关键词： lysis Grazing Bacteria Viruses Prokaryotic and Eukaryotic Picophytoplankton Dilution Assay

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