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Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma:A comprehensive review

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World Journal of Hepatology 2024年第4期16卷 537-549页

作者： Jing-Jing Li Jia-Xi Mao Han-Xiang Zhong Yuan-Yu Zhao Fei Teng Xin-Yi Lu Li-Ye Zhu Yang Gao Hong Fu Wen-Yuan Guo Department of Liver Surgery and Organ Transplantation Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003China

The tumor microenvironment is a complex network of cells,extracellular matrix,and signaling molecules that plays a critical role in tumor progression and *** and blood vessels are major routes for solid tumor metastasis and essential parts of tumor drainage ***,recent studies have shown that lymphatic endothelial cells(LECs)and blood endothelial cells(BECs)also play multifaceted roles in the tumor microenvironment beyond their structural functions,particularly in hepatocellular carcinoma(HCC).This comprehensive review summarizes the diverse roles played by LECs and BECs in HCC,including their involvement in angiogenesis,immune modulation,lymphangiogenesis,and *** providing a detailed account of the complex interplay between LECs,BECs,and tumor cells,this review aims to shed light on future research directions regarding the immune regulatory function of LECs and potential therapeutic targets for HCC.

关键词： lymphatic endothelial cells Blood endothelial cells Hepatocellular carcinoma Tumor microenvironment

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Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease

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Neural Regeneration Research 2018年第4期13卷 709-716页

作者： Ya-Ru Wen Jun-Hua Yang Xiao Wang Zhi-Bin Yao Department of Anatomy and Neurobiology Zhongshan School of MedicineSun Yat-sen University Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen University

Impaired amyloid-β clearance from the brain is a core pathological event in Alzheimer＇s *** therapeutic effect of current pharmacotherapies is unsatisfactory,and some treatments cause severe side *** meningeal lymphatic vessels might be a new route for amyloid-β *** study investigated whether promoting dural lymphangiogenesis facilitated the clearance of amyloid-β from the ***,human lymphatic endothelial cells were treated with 100 ng/m L recombinant human vascular endothelial growth factor-C（rh VEGF-C） *** microscopy verified that rh VEGF-C,a specific ligand for vascular endothelial growth factor receptor-3（VEGFR-3）,significantly promoted tube formation of human lymphatic endothelial cells in *** an in vivo study,200 μg/m L rh VEGF-C was injected into the cisterna magna of APP/PS1 transgenic mice,once every 2 days,four times in *** staining demonstrated high levels of dural lymphangiogenesis in Alzheimer＇s disease *** week after rh VEGF-C administration,enzyme-linked immunosorbent assay results showed that levels of soluble amyloid-β were decreased in cerebrospinal fluid and *** Morris water maze test demonstrated that spatial cognition was *** results indicate that the upregulation of dural lymphangiogenesis facilities amyloid-β clearance from the brain of APP/PS1 mice,suggesting the potential of the VEGF-C/VEGFR-3 signaling pathway as a therapeutic target for Alzheimer＇s disease.

关键词： nerve regeneration dura mater lymphangiogenesis amyloid-β Alzheimer's disease recombinant haman vascular endothelial growth factor-C lymphatic endothelial cells lymphatic clearance neural regeneration

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