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Endoscopic ultrasound fine needle aspiration vs fine needle biopsy for pancreatic masses,subepithelial lesions,and lymph nodes

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World Journal of Gastroenterology 2021年第26期27卷 4194-4207页

作者： Irving Levine Arvind J Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health SystemNew Hyde ParkNY 11040United States

Endoscopic ultrasound tissue acquisition,in the form of both fine needle aspiration(EUS-FNA)and fine needle biopsy(EUS-FNB),is utilized for pancreatic mass lesions,subepithelial lesions,and lymph node *** procedures are safe and yield high diagnostic *** its high diagnostic yield,EUS-FNA has potential limitations associated with cytological aspirations,including inability to determine histologic architecture,and a small quantitative sample for further immunohistochemical ***-FNB,with its larger core biopsy needle,was designed to overcome these potential ***,it remains unclear which technique should be used and for which *** trials are plagued by heterogeneity at every stage of comparison;including variable needles used,and different definitions of endpoints,which therefore limit ***,we present a review of prospective trials,systematic reviews,and meta-analyses on studies examining EUS-FNA vs *** comparative trials of EUS-FNA vs EUS-FNB primarily focus on pancreatic mass lesions,and yield conflicting results in terms of demonstrating the superiority of one ***,consistent among trials is the potential for diagnosis with fewer passes,and a larger quantity of sample achieved for next generation *** regard to subepithelial lesions and lymph node biopsy,fewer prospective trials exist,and larger prospective studies are *** on the available literature,we would recommend EUS-FNB for peri-hepatic lymph nodes.

关键词： Endoscopic ultrasound fine needle aspiration Endoscopic ultrasound fine needle biopsy Pancreatic lesions Subepithelial lesions lymph node biopsy

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Castleman disease and TAFRO syndrome:To improve the diagnostic consciousness is the key

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World Journal of Clinical Cases 2022年第5期10卷 1536-1547页

作者： Qian-Yun Zhou Department of Critical Care Medicine Peking University Shougang HospitalBeijing 100144China

BACKGROUND Castleman disease(CD)and TAFRO syndrome are very rare in clinical *** clinicians,especially non-hematological clinicians,do not know enough about the two diseases,so it often leads to misdiagnosis or missed *** To explore the clinical features and diagnosis of CD and TAFRO *** We retrospectively collected the clinical and laboratory data of 39 patients who were diagnosed with CD from a single medical *** Clinical classification identified 18 patients(46.15%)with unicentric Castleman disease(UCD)and 21 patients(53.85%)with multicentric Castleman disease(MCD),the latter is further divided into 13 patients(33.33%)with idiopathic multicentric Castleman disease-not otherwise specified(iMCD-NOS)and 8 patients(20.51%)with TAFRO *** and iMCD are significantly different in clinical manifestations,treatment,and ***,a few patients with MCD were diagnosed as UCD in their early *** was a correlation between two of Thrombocytopenia,anasarca and elevated creatinine,which were important components of TAFRO *** UCD group,the pathologies of lymph modes were mostly hyaline vascular type(13/18,72.22%),however plasma cell type or mixed type could also *** iMCD-NOS group and TAFRO syndrome group,the pathologies of lymph mode shown polarity of plasma cell type and hyaline vascular type *** with patients with TAFRO syndrome,patients with iMCD-NOS were diagnosed more *** The clinical and pathological types of CD are not completely separate,there is an intermediate situation or mixed characteristics between two ends of clinical and pathological *** clinical manifestations of patients with CD are determined by their pathological *** syndrome is a special subtype of iMCD with unique clinical manifestations.

关键词： Castleman disease Diagnosis lymph node biopsy TAFRO syndrome

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Retrospective Study of Castleman's Disease:A Report of Fourteen Cases and Review of the Literature

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Chinese Journal of Clinical Oncology 2007年第3期4卷 195-200页

作者： Waiyi Zou Huixia Lan Chang Su Yunxian Chen Juan Li Shaokai Luo Department of Hematology the First Affiliated Hospital of Zhongshan University Guangzhou 510080 China.

OBJECTIVE To enhance the understanding of Castleman’s disease (CD), and to improve its diagnosis and management. METHODS Clinical features and related information on diagnosis and treatment of 14 cases of CD were retrospectively analyzed and the literature reviewed. RESULTS Based on the clinical classification, localized CD was found in 8 of the 14 cases. Both the results of lymph node biopsy and histopathology indicated they were a hyaline-vascular type. The multicentric type CD was detected in 6 cases, among which 4 were plasma cell type and 2 mixed type based on histopathologic examination. There were a variety of clinical situa-tions in the 14 cases, with a lack of specificity. They were previously misdiag-nosed as other diseases, and final diagnosis depended on a histopathologic examination. The 8 patients with localized CD underwent excision, without recurrence up to now. The 6 patients with multicentric-type CD were treated with glucocorticoids or combined chemotherapy, and all achieved remission. CONCLUSIONS CD has complicated clinical manifestations and is difficult to diagnose. lymph node biopsy is important for early diagnosis. An optimal curative effect can be achieved with a suitable therapeutic option, based on histopathology and clinical classification.

关键词： Castleman's disease lymph node biopsy histopathology diagnosis treatment.

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