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Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1437-1452页

作者： Bin-Sheng Wang Chen-Li Zhang Xiang Cui Qiang Li Lei Yang Zhi-Yun He Ze Yang Miao-Miao Zeng Nong Cao Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Third Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer,characterized by a multifactorial etiology and high heterogeneity,continues to confound researchers in terms of its ***,a natural anticancer agent,exhibits therapeutic promise in gastric *** effects include promoting cell apoptosis,curtailing tumor angiogenesis,and enhancing sensitivity to radiation and *** noncoding RNAs(lncRNAs)have garnered significant attention as biomarkers for early screening,diagnosis,treatment,and drug response because of their remarkable specificity and *** investigations have revealed an association between aberrant lncRNA expression and early diagnosis,clinical staging,metastasis,drug sensitivity,and prognosis in gastric cancer.A profound understanding of the intricate mechanisms through which lncRNAs influence gastric cancer develop-ment can provide novel insights for precision treatment and tailored management of patients with gastric *** study aimed to unravel the potential of curcumin in suppressing the malignant behavior of gastric cancer cells by upregu-lating specific lncRNAs and modulating gastric cancer onset and *** To identify lncRNAs associated with curcumin treatment and investigate the role of lncRNA AC022424.2 in the effects of curcumin on gastric cancer cell apoptosis,proliferation,and ***,these findings were validated in clinical *** The study employed CCK-8 assays to assess the impact of curcumin on gastric cancer cell proliferation,flow cytometry to investigate its effects on apoptosis,and scratch and Transwell assays to evaluate its influence on the migration and invasion of BGC-823 and MGC-803 *** blotting was used to gauge changes in the protein expression levels of CDK6,CDK4,Bax,Bcl-2,caspase-3,P65,and the PI3K/Akt/mTOR pathway in gastric cancer cell lines after curcumin *** expression of lncRNAs before and after curcumin treatment was assessed using lncRNA seq

关键词： Gastric cancer Curcumin Long noncoding RNA AC022424.2 Apoptosis Akt/PI3K pathway lymph metastasis

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