检索结果-南通市图书馆

Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 459-464页

作者： Shi Liu Chao Yuan Yun-Fu Cui Bai-Xiang Li Li-Jie Wu Ying Liu The 2nd Affiliated Hospital of Harbin Medical University Daqing Oilfield General Hospital Group Rangbei Hospilal Harbin Medical University School of Public Health The 3rd Affiliated Hospital of Qiqihar Medical College

Objective:To investigate the precise species of tick vector and the Borrelia spirochete pathogen at the Heilongjiang Province international border with Russia.Methods:In dus study,ticks were collected from 12 Heilongjiang border crossings(including grasslands,shrublands,forests,and plantantions) to determine the rate and species type of spirochete-infected ticks and the most prevalent spirochete genotypes.Results:The ticks represented three genera and four species of the Ixodidae family[Ixodes persidcatus,Dermacentor silvarum,Haemapkysalis concinna and Haemaphysalis japonica].Ixodes persulcatus had the highest amount of Borrelia burgdorferi sensu lata infection of 25.6%and the most common species of Borrelia isolated from Ixodes persulcatus mas Borrelia garinii,strain PD91.Conclusions:Our results suggest that Borrelia garinii PD91- infected Ixodes persulcatus may be the principal cause of Lyme disease in the border crossing areas of Heilongjiang Province.

关键词： Lyme disease Tick Borrelia burgdorferi sensu lato Borrelia garinii

EPIDEMIC SPREAD ON ONE-WAY CIRCULAR-COUPLED NETWORKS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2019年第6期39卷 1713-1732页

作者：徐忠朴傅新楚 Department of Mathematics Shanghai University

Real epidemic spreading networks are often composed of several kinds of complex networks interconnected with each other, such as Lyme disease, and the interrelated networks may have different topologies and epidemic dynamics. Moreover, most human infectious diseases are derived from animals, and zoonotic infections always spread on directed interconnected networks. So, in this article, we consider the epidemic dynamics of zoonotic infections on a unidirectional circular-coupled network. Here, we construct two unidirectional three-layer circular interactive networks, one model has direct contact between interactive networks, the other model describes diseases transmitted through vectors between interactive networks, which are established by introducing the heterogeneous mean-field approach method. Then we obtain the basic reproduction numbers and stability of equilibria of the two models. Through mathematical analysis and numerical simulations, it is found that basic reproduction numbers of the models depend on the infection rates, infection periods, average degrees, and degree ratios. Numerical simulations illustrate and expand these theoretical results very well.

关键词： epidemic dynamics coupled network Lyme disease infective medium basic reproduction number

Lipid Replacement Therapy with a Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Fatigue in Intractable Chronic Fatiguing Illnesses and Chronic Lyme Disease Patients

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2012年第3期3卷 163-170页

作者： Garth L. Nicolson Robert Settineri Rita Ellithorpe Department of Molecular Pathology The Institute for Molecular Medicine Huntington Beach USA Sierra Research Irvine USA Tustin Longevity Center Tustin USA

Objectives: A preliminary open label study was initiated to determine if a combination oral supplement containing a mixture of phosphoglycolipids, coenzyme Q10 and microencapsulated NADH could affect fatigue levels in long-term patients with intractable fatigue. Fatigue was determined by the validated Piper Fatigue Scale before, during and after the trial. Participants included 58 patients (30 females and 28 males) with chronic fatigue syndrome/myalgic encephalomyelitis, chronic Lyme disease or other fatiguing illnesses, such as fibromyalgia syndrome or Gulf War illness. These patients had been symptomatic for an average of 17.1 ± 0.6 years, had been seen by many physicians (15.2 ± 0.7) and had used many other supplements and drugs (35.4 ± 2.7) without apparent reductions in their fatigue. Results: Participants in the study responded to the combination test supplement, showing a 30.7% reduction in overall fatigue within 60 days (P2 = 0.960). The data also suggested that further reductions were likely if the participants had continued the supplement beyond the 8-week trial. Males responded slightly better to the combination supplement than females, and the patients with the most severe forms of fatigue responded slightly better than those with milder fatigue, independent of their diagnosis. Conclusions: The combination supplement was a safe and effective method to significantly reduce fatigue in long-term patients with intractable chronic fatigue.

关键词： Fatigue Chronic Fatigue Syndrome Lyme Disease CoQ10 NADH Phospholipids

Hypothesizing That Pediatric Autoimmune Neuropsychiatric Associated Streptococcal (PANDAS) Causes Rapid Onset of Reward Deficiency Syndrome (RDS) Behaviors and May Require Induction of “Dopamine Homeostasis”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Immunology 2022年第3期12卷 65-75页

作者： Kenneth Blum Catherine A. Dennen Eric R. Braverman Ashim Gupta David Baron Bernard William Downs Debasis Bagchi Panayotis Thanos Maureen Pollock Jag Khalsa Igor Elman Abdalla Bowirrat Rajendra D. Badgaiyan Center for Mental Health and Sports Psychiatry Western University Health Sciences Pomona USA The Kenneth Blum Behavioral & Neurogenetic Institute Austin USA Department Psychiatry Boonshoff School of Medicine Wright University Dayton USA Institute of Psychology ELTE E&#246tv&#246s Loránd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington USA Division of Nutrigenomics Victory Nutrition International Inc. Bonita Springs USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Department of Family Medicine Jefferson Health Northeast Philadelphia USA Future Biologics Lawrenceville USA Department of Pharmaceutical Sciences Texas Southern University Houston USA Department of Psychology & Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA) Research Institute on Addictions University at Buffalo Buffalo USA Department of Microbiology Immunology and Tropical Medicine School of Medicine George Washington University Washington DC USA Cambridge Health Alliance Harvard Medical School Cambridge USA Department of Psychiatry Ichan School of Medicine at Mount Sinai New York USA Department of Psychiatry South Texas Veteran Health Care System Audie L. Murphy Memorial VA Hospital Long School of Medicine University of Texas Health Science Center San Antonio USA

Pediatric autoimmune neuropsychiatric disorders associated with group A streptococcal infections (PANDAS) is a concept that is used to characterize a subset of children with neuropsychiatric symptoms, tic disorders, or obsessive-compulsive disorder (OCD), whose symptoms are exacerbated by group A streptococcal (GAS) infection. PANDAS has been known to cause a sudden onset of reward deficiency syndrome (RDS). RDS includes multiple disorders that are characterized by dopaminergic signaling dysfunction in the brain reward cascade (BRC), which may result in addiction, depression, avoidant behaviors, anxiety, tic disorders, and/or OCD. According to research by Blum et al., the dopamine receptor D2 (DRD2) gene polymorphisms are important prevalent genetic determinants of RDS. The literature demonstrates that infections like Borrelia and Lyme, as well as other infections like group A beta-hemolytic streptococcal (GABHS), can cause an autoimmune reaction and associated antibodies target dopaminergic loci in the mesolimbic region of the brain, which interferes with brain function and potentially causes RDS-like symptoms/behaviors. The treatment of PANDAS remains controversial, especially since there have been limited efficacy studies to date. We propose an innovative potential treatment for PANDAS based on previous clinical trials using a pro-dopamine regulator known as KB220 variants. Our ongoing research suggests that achieving “dopamine homeostasis” by precision-guided DNA testing and pro-dopamine modulation could result in improved therapeutic outcomes.

关键词： PANDAS CANS Reward Deficiency Syndrome Group A Beta-Hemolytic Streptococcal (GABHS) Pro-Dopamine Regulation Dopamine Homeostasis Molecular Mimicry Lyme Borrelia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

莱姆病螺旋体检测技术的进展

中国实验诊断学 2014年第3期18卷 514-516页

作者：郑旭王玮琳丁旭乔萍刘阳吉林大学基础医学院药理系吉林长春130021 吉林出入境检验检验局吉林长春130062

1 莱姆病螺旋体简介莱姆病（Lyme Disease,LD）最早发现于美国的Lyme镇并由此得名,莱姆病是由蜱传播的一种自然疫源性、人畜共患疾病,通过肩突硬蜱感染人体宿主,可引起多系统器官损害,游走性红斑、神经炎、关节炎、心肌炎等.1982年Burg... 详细信息

1 莱姆病螺旋体简介莱姆病（Lyme Disease,LD）最早发现于美国的Lyme镇并由此得名,莱姆病是由蜱传播的一种自然疫源性、人畜共患疾病,通过肩突硬蜱感染人体宿主,可引起多系统器官损害,游走性红斑、神经炎、关节炎、心肌炎等.1982年Burgdorfer W等人成功从肩突硬蜱（Ixodes ricinus）中分离出莱姆病病原体——螺旋体1,螺旋体感染通常是开始于肩突硬蜱幼虫阶段,

关键词：莱姆病螺旋体检测技术多系统器官损害人畜共患疾病自然疫源性游走性红斑螺旋体感染 Lyme

Antabuse for Lyme Disease: The Way Forward

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Neuroscience 2020年第1期10卷 1-7页

作者： David S. Younger Beverley F. Murphy Department of Clinical Medicine CUNY School of Medicine City College New York USA

Despite leadership by dedicated lay organization and patient-based advocacy groups, the way forward for prospective candidates for disulfiram treatment has been difficult. This article provides the background, overview of disulfiram, in particular its intended use in post-treatment Lyme disease syndrome after a standard of care course of antibiotics fails to alleviate symptoms of tick borne disease. A series of recommendations are offered to guide patients and clinicians.

关键词： Disulfiram Antabuse Lyme Disease Immune Globulin Therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

心停止滴答响

World Journal of Cardiology 2013年第5期5卷 148-150页

作者： Paras Karmacharya Madan Raj Aryal Department of Medicine Reading Health System West Reading PA 19611 United States

Although Lyme carditis is relatively rare within 4-6 wk of exposure, it can uncommonly present as the first sign of disseminated Lyme disease. Here we present 17 year old boy who presented to the emergency department with chest discomfort and was later found to have complete atrioventricular block due to Lyme carditis. He had uneventful recovery after empiric treatment with ceftriaxone. Our case highlights the importance of considering reversible causes of complete AV block since appropriate therapy can avoid the need for permanent pacemaker insertion.

关键词： Lyme carditis Heart block Antibiotic Pacemaker Disseminated Lyme Borrelia burgdorferi Tick bite

Serial Brain Positron Emission Tomography Fused to Magnetic Resonance Imaging in Post-Infectious and Autoantibody-Associated Autoimmune Encephalitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Neuroscience 2019年第3期9卷 153-156页

作者： David S. Younger Department of Clinical Medicine CUNY School of Medicine at City College New York NY USA The Graduate School of Public Health and Health Policy City University of New York New York NY USA

Serial positron emission tomography fused to magnetic resonance imaging showed progression of GAD65 autoimmune encephalitis.

关键词： GAD65 Post-Treatment Lyme disease Autoimmune Encephalitis Positron Emission Tomography Magnetic Resonance Imaging

Novel <i>AARS</i>2 Gene Mutation Producing Leukodystrophy: A Patient with Peripheral Demyelinating Polyneuropathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Neuroscience 2019年第4期9卷 224-228页

作者： David S. Younger

Novel AARS2 gene mutations encoding mitochondrial alanyl-tRNA synthetase are important in the spectrum of different phenotypes expressed in the nervous system. Leukodystrophy and ovarian failure in females are common phenotypes. Peripheral demyelination is not a recognized aspect of the AARS2 phenotype. A patient with preceding Lyme neuroborreliosis developed progressive leukodystrophy and peripheral demyelinating motor polyneuropathy. Serial magnetic resonance imaging showed progressive inflammatory demyelination extending to the corticospinal tracts. Treatment with a standard of care of antibiotics and immune-modulatory therapy employing intravenous immune globulin was employed. The contribution of neuroborreliosis is not well understood in the expression of the AARS2 phenotype.

关键词： AARS2 Mutation Leukodystrophy Lyme Neuroborreliosis Magnetic Resonance Imaging Electrodiagnostic Studies Cerebrospinal Fluid Epidermal Nerve Fibers Sural Nerve Muscle Biopsy IVIg

Book Review: I-Cubed and <i>The Autoimmune Brain</i>, A Five-Step Plan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Neuroscience 2020年第1期10卷 29-36页

作者： David S. Younger

The Autoimmune Brain1 explains I-Cubed, a shorthand for post-infectious autoimmunity that results from the multiplier effect of infection, immunity and inflammation, when protective immunity becomes the source of autoimmunity, conditioned by applicable environmental and genetic predisposing factors. In keeping with the post-infectious autoimmune nature of I-Cubed, neurologic and psychiatric symptoms evolve beyond a standard of care course of antibiotic therapy. Extensive serologic, electrophysiological and neuroradiographic diagnostic testing provides clues to areas of central, peripheral and autonomic nervous system, and systemic involvement that guide therapy. A multimodality therapeutic approach employing immune modulatory (Ig) therapy that addresses the underlying mechanisms and not just the symptoms of Cubed disorders is most effective. Representative cases of post-infectious autoimmunity associated with Lyme disease and PANDAS are presented.

关键词： Neuropsychiatry Lyme Disease PANDAS I-Cubed Post-Infectious Autoimmunity