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中国天然药物 2012年第2期10卷 125-128页

作者： NorShahidah Sahidan Chee Yan Choo A.Latiff Razali Jaman MedChem Herbal Research Group Faculty of Pharmacy Universiti Teknologi MARA 42300 Selangor Malaysia Faculty of Sciences and Technology Universiti Kebangsaan Malaysia Bangi Selangor Malaysia Faculty of Sciences and Technology Universiti Kebangsaan Malaysia Bangi Selangor Malaysia

(-) Huperzine A is a bioactive alkaloid from Huperzia serrata (lycopodiaceae) used for the treatment of Alzheimer's disease. High yielding (-) huperzine A species is of interest for mass propagation since it grows slowly in temperate countries. The content of (-) huperzine A from temperate countries was reported but none reported from tropical species. The aim of this study was to evaluate the content of (-) huperzine A from tropical club mosses and further identify a high yielding species. Club mosses from lycopodiaceae family were collected from Peninsular Malaysia. The collected club mosses were dried, pulverized and extracted with methanol. A gradient reverse phase HPLC-photodiode array detector method with increasing amount of methanol in 0.01 % trifluoroacetic acid was developed. The calibration curve was linear from 5 to 100 g·mL-1 with correlation coefficient, r2, of 0.998 1. The precision for both intra-and inter-day peak area were between 0.48% to 1.24 % and 0.95% to 3.85 %, respectively. The recovery of the method was between 99.8% to 103.8 %. Though geographically segregated, (-) huperzine A content in Huperzia phlegmaria and *** found in the tropics was highest and similar to species in Australasia. Both species may provide a good source of (-) huperzine A.

关键词： lycopodiaceae (-) Huperzine A HPLC Tropics

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A new alkaloid and arbutin from the whole plant of Huperzia serrata

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Chinese Journal of Chemistry 2000年第4期18卷 614-616页

作者：高文运王保德李医明蒋山好朱大元 State Key Laboratory of New Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 200031 China

A new Lycopodium alkaloid together with a phenolic glycoside—arbutin, were isolated from the whole plant of Huperzia serrata. The new compound was assigned the trivial name of huperzine I. The structures of these two... 详细信息

关键词： Huperzia serrata lycopodiaceae isolation structural elucidation alkaloid phenolic glucoside

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Palcernuine, the first [5/6/6/6]-cernuane-type alkaloid from Palhinhaea cernua ***

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Chinese Chemical Letters 2016年第6期27卷 969-973页

作者： Yu Tang Juan Xiong Yike Zou Bastien Nay Li-Jun Wang Jin-Feng Hu Department of Natural Products Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Chemistry University of PennsylvaniaPhiladelphia 19104-6323USA Unite Molecules de Communication et Adaptation des Micro-organismes Sorbonne UniversitesMuseum National d'Histoire NaturelleCentre National de la Recherche Scientifique(CNRS UMR 7245)Paris 75005France

One novel（named palcernuine, 1） and five known cernuane-type（2–6） alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism（ECD） spectra. A plausible biosynthetic pathway to 1 is proposed.

关键词： Palhinhaea cernua f.sikkimensis lycopodiaceae Palcernuine Cernuane-type alkaloids Biosynthetic pathway

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