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Journal of Integrative Plant Biology 2008年第8期50卷 991-996页

作者： Hongyan Gao Hongliang Zhu Yi Shao Anjun Chen Chengwen Lu Benzhong Zhu Yunbo Luo College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 China

For elucidating the regulatory mechanism of ethylene on carotenoid-related volatiles （open chain） compounds and the relationship between lycopene and carotenoid-related volatiles, transgenic tomato fruits in which ACC synthase was suppressed were used. The transgenic tomato fruit showed a significant reduction of lycopene and aroma volatiles with low ethylene production. 6-methyl-5-hepten-2-one, 6-methyl-5-hepten-2-ol and geranylacetone, which were suspected to be lycopene degradation products, were lower than those in wild type tomato fruits. In order to identify whether lycopene accumulation effects the biosynthesis of some carotenoid-related volatiles independent of ethylene in tomato or not, the capability of both wild type and transgenic tomato fruits discs to convert lycopene into carotenoid-related volatiles was evaluated. The data showed that external lycopene could convert into 6-methyl-5-hepten-2-one and 6-methyl-5-hepten-2-ol in vivo, indicating that the strong inhibition of ethylene production had no effect on enzymes in the biosynthesis pathway of some carotenoid-related volatUes. Therefore, in ACS-suppression transgenic tomato fruits, the low levels of 6-methyl- 5-hepten-2-one, 6-methyl-5-hepten-2-ol was due to decreased lycopene accumulation, not ethylene production. Ethylene only affected the accumulation of lycopene, and then indirectly influenceed the level of lycopene-related volatiles.

关键词： aroma volatiles ethylene lycopene tomato

lycopene and male infertility

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Asian Journal of Andrology 2014年第3期16卷 420-425页

作者： Damayanthi Durairajanayagam Ashok Agarwal Chloe Ong Pallavi Prashast Center for Reproductive Medicine Glickman Urological and Kidney Institute Cleveland Clinic Cleveland Ohio USA Faculty of Medicine MARA University of Technology Sungai Buloh Selangor Malaysia.

Excessive amounts of reactive oxygen species （ROS） cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inflicted on spermatozoa. It is postulated that lycopene may have other beneficial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility--lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility.

关键词： antioxidants lycopene male infertility oxidative stress reactive oxygen species sperm parameters

lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression

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Asian Journal of Andrology 2019年第1期21卷 80-85页

作者： Li-Ning Jiang Ya-Bin Liu Bing-Hui Li Department of Surgery II Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Urology Surgery I Cangzhou Central Hospita Cangzhou 061000China

lycopene is a natural compound that alleviates oxidative stress and inflammation,exerting therapeutic effects in a number of *** aim of this study is to investigate the efficacy of lycopene in inhibiting prostate *** viability assays indicated the dose-and time-dependent toxicity of lycopene in prostate cancer *** V/propidium iodide double-staining assays revealed the strong apoptotic effects of *** levels of inflammatory factors,including interleukin-1 (ILl),IL6,ILS,and tumor necrosis factor-α(TNF-α),in lycopene-treated cells were also reduced by lycopene *** the increasing dose of lycopene,the survival of mice bearing prostate cancer xenografts was significantly improved (P lycopene is a promising chemotherapy drug,which inhibits prostate cancer progression by suppressing the inflammatory response.

关键词： dietary supplement inflammation lycopene prostate cancer

Oil-in-water nanoemulsions loaded with lycopene extracts encapsulated by spray drying:Formulation,characterization and optimization

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Chinese Journal of Chemical Engineering 2024年第6期70卷 73-81页

作者： Junyang Li Roberta Campardelli Giuseppe Firpo Jingtao Zhang Patrizia Perego Department of Civil Chemical and Environmental Engineering(DICCA)University of GenoaVia Opera Pia 15Genova 16145Italy Department of Physics University of GenoaVia Dodecaneso 32Genova 16146Italy School of Food and Bioengineering Zhengzhou University of Light IndustryZhengzhou 450002China

lycopene is very susceptible to degradation once released from the protective chromoplast *** this study,oil-in-water(O/W)nanoemulsions coupled with spray drying technology were applied for the encapsulation and stabilization of lycopene extracted from tomato *** extract was obtained by ultrasound-assisted *** were prepared by a high-speed rotor stator using isopropyl myristate as the oil phase and Pluronic F-127 as the emulsifier for the aqueous external *** effect of emulsification process parameters was *** drying of the produced emulsions was attempted to obtain a stabilized dry powder after the addition of a coating *** effect of different coating agents(maltodextrin,inulin,gum arabic,pectin,whey and polyvinylpyrrolidone),drying temperature(120-170℃),and feed flow rate(3-9 ml·min^(-1))on the obtained particles was *** revealed that the emulsion formulation of 20/80(O/W)with 1.5%(mass fraction)of Pluronic F-127 as stabilizer in the aqueous phase resulted in a stable nanoemulsion with droplet sizes in the range of 259-276 nm with a unimodal and sharp size *** extract in the nanoemulsion was well protected at room temperature with a degradation rate of lycopene of about 50%during a month of storage *** most stable emulsions were then processed by spray drying to obtain a dry *** drying was particularly successful when using maltodextrin as a coating agent,obtaining dried spherical particles with mean diameters of(4.87±0.17)μm with a smooth *** possibility of dissolving the spray dried powder in order to *** original emulsion was also successfully verified.

关键词： Emulsions Powders Stability Isopropyl myristate lycopene Spray-drying

Supplemental blue and red light promote lycopene synthesis in tomato fruits

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Journal of Integrative Agriculture 2019年第3期18卷 590-598页

作者： XIE Bao-xing WEI Jing-jing ZHANG Yi-ting SONG Shi-wei SU Wei SUN Guang-wen HAO Yan-wei LIU Hou-cheng College of Horticulture South China Agricultural UniversityGuangzhou 510642P.R.China

lycopene, one of the strongest natural antioxidants known and the main carotene in ripe tomato, is very important for human health. Light is well known to be one of the most important environmental stimuli influencing lycopene biosynthesis; specifically, red light induces higher lycopene content in tomato. However, whether blue light promotes lycopene synthesis remains elusive and exactly how light stimulation promotes lycopene synthesis remains unclear. We applied supplemental blue and red lighting on tomato plants at anthesis to monitor the effect of supplemental blue and red lighting on lycopene synthesis. Our results showed that supplemental blue/red lighting induced higher lycopene content in tomato fruits; furthermore, we found that the expression of key genes in the lycopene synthesis pathway was induced by supplemented blue/red light. The expression of light signaling components, such as red-light receptor phytochromes(PHYs), blue-light receptor cryptochromes(CRYs) and light interaction factors, phytochrome-interacting factors(PIFs) and ELONGATED HYPOCOTYL 5(HY5) were up-or down-regulated by blue/red lighting. Thus, blue and red light increased lycopene content in tomatoes by inducing light receptors that modulate HY5 and PIFs activation to mediate phytoene synthase 1(PSY1) gene expression. These results provide a sound theoretical basis for further elucidation of the light regulating mechanism of lycopene synthesis in tomatoes, and for instituting a new generation of technological innovations for the enhancement of lycopene accumulation in crop production.

关键词： blue light red light lycopene phytochromes cryptochromes

Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia

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Neural Regeneration Research 2020年第2期15卷 332-341页

作者： Ning-Wei Zhu Xiao-Lan Yin Ren Lin Xiao-Lan Fan Shi-Jie Chen Yuan-Ming Zhu Xiao-Zhen Zhao Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Pharmacy Zhejiang Pharmaceutical CollegeNingboZhejiang ProvinceChina Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina

Oxidative stress is involved in the pathogenesis of vascular dementia. Studies have shown that lycopene can significantly inhibit oxidative stress;therefore, we hypothesized that lycopene can reduce the level of oxidative stress in vascular dementia. A vascular dementia model was established by permanent bilateral ligation of common carotid arteries. The dosage groups were treated with lycopene(50, 100 and 200 mg/kg) every other day for 2 months. Rats without bilateral carotid artery ligation were prepared as a sham group. To test the ability of learning and memory, the Morris water maze was used to detect the average escape latency and the change of search strategy. Hematoxylin-eosin staining was used to observe changes of hippocampal neurons. The levels of oxidative stress factors, superoxide dismutase and malondialdehyde, were measured in the hippocampus by biochemical detection. The levels of reactive oxygen species in the hippocampus were observed by dihydroethidium staining. The distribution and expression of oxidative stress related protein, neuron-restrictive silencer factor, in hippocampal neurons were detected by immunofluorescence histochemistry and western blot assays. After 2 months of drug administration,(1) in the model group, the average escape latency was longer than that of the sham group, and the proportion of straight and tend tactics was lower than that of the sham group, and the hippocampal neurons were irregularly arranged and the cytoplasm was hyperchromatic.(2) The levels of reactive oxygen species and malondialdehyde in the hippocampus of the model group rats were increased, and the activity of superoxide dismutase was decreased.(3) lycopene(50, 100 and 200 mg/kg) intervention improved the above changes, and the lycopene 100 mg/kg group showed the most significant improvement effect.(4) Neuron-restrictive silencer factor expression in the hippocampus was lower in the sham group and the lycopene 100 mg/kg group than in the model group.(5) Th

关键词： bilateral carotid artery ligation lycopene hippocampus learning and memory malondialdehyde neuron neuron-restrictive silencer factor reactive oxygen species superoxide dismutase

Dietary lycopene supplementation improves meat quality,antioxidant capacity and skeletal muscle fiber type transformation in finishing pigs

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Animal Nutrition 2022年第1期8卷 256-264页

作者： Wanxue Wen Xiaoling Chen Zhiqing Huang Daiwen Chen Bing Yu Jun He Yuheng Luo Hui Yan Hong Chen Ping Zheng Jie Yu Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Institute of Animal NutritionSichuan Agricultural UniversityChengduSichuan 611130China College of Food Science Sichuan Agricultural UniversityYa'anSichuan 625014China

This study aimed to investigate effects of dietary lycopene supplementation on meat quality,antioxidant ability and muscle fiber type transformation in finishing *** a 70-day experiment,18 DurocLandraceYorkshire barrows were randomly allocated to 3 dietary treatments including a basal diet supplemented with 0,100 and 200 mg/kg lycopene,*** dietary treatment had 6 replicates with one pig *** showed that dietary 200 mg/kg lycopene supplementation increased muscle redness a^(*)value,intramuscular fat and crude protein contents,and decreased muscle lightness L^(*)and yellowness b^(*)values(Plycopene to the diet of finishing pigs improved color,nutritional value and juiciness of pork after *** also showed that dietary lycopene supplementation enhanced antioxidant capacity of finishing pigs(Plycopene significantly increased slow myosin heavy chain(MyHC)protein level and slow-twitch fiber percentage,and decreased fast MyHC protein level and fast-twitch fiber percentage(Plycopene to the diet of finishing pigs promoted muscle fiber type conversion from fast-twitch to ***,we provide the first evidence that dietary 200 mg/kg lycopene supplementation improves meat quality,enhances antioxidant capacity and promotes muscle fiber type transformation from fast-twitch to slow-twitch in finishing pigs.

关键词： lycopene Meat quality Antioxidant capacity Skeletal muscle fiber type transformation Finishing pig

Effect of Pressure on Absorption Spectra of lycopene in n-Hexane and CS2 Solvents

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Chinese Physics Letters 2010年第1期27卷 108-110页

作者：张伟刘伟龙郑植仁霍明明李艾华杨彬 Center for Condensed Matter Science and Technology Department of Physics Harbin Institute of Technology Harbin 150001

The absorption spectra of lycopene in n-hexane and CS2 are measured under high pressure and the results are compared with β-carotene. In the lower pressure range, the deviation from the linear dependence on the Bayliss parameter （BP） for β-carotene is more visible than that for lycopene. With the further increase of the solvent BP, the 0-0 bands of lycopene and β-carotene red shift at almost the same rate in n-hexane; however, the 0-0 band of lycopene red shifts slower than that of β-carotene in CS2. The origins of these diversities are discussed taking into account the dispersion interactions and structures of solute and solvent molecules.

关键词： ABSORPTION spectra lycopene HEXANE CARBON disulfide SOLVENTS HIGH pressure (Science) DISPERSION

lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第12期2卷 975-980页

作者： Sheik Abdulazeez Sheriff Thiruvengadam Devaki Department of Biochemistry University of MadrasGuindy Campus

Objective:To investigate the effect of lycopene on lipoprotein metabolism during D-galactosamine/lipopolysacchoride(D-Gal/LPS)induced hepatitis in experimentul ***:The efficacy of lycopene was validated during D-Gal/LPS induced hepatitis by analyzing the activity of lipid metabolizing enzymes such as lipoprotein lipase(LPL),lecithincholesterol acyl transferase(LCAT)and hepatic triglyceride lipase(HTCL).Lipo protein analyses were done by the estimation of very low density lipoprotein cholesterol(VLDL),low density lipoprotein cholesterol(LDL)and high density lipoprotein cholesterol(HDL).Remits:The toxic insult of D-galactosamine/lipopolysaccharide(D-Gal/LPS)in experimental group of animals reduces the normal values of lipid metabolizing enzymes due to liver *** significant drop in the levels of HDL and concomitant increase in the values of VLDL and LDL were *** pretreatment of lycopene restore these altered values to near normal level in experimental group of ***:In the light of results,it can be concluded that administration lycopene stabilizes the lipoprotein levels by regulating the lipid metabolizing enzymes through its antioxidant defense and helps to maintain the normal lipid metabolism during toxic injury in liver.

关键词： lycopene Dyslipidemia Galactosamine Antioxidants Lipoproteins

Improvement of lycopene biosynthesis in waaC and waaF mutants of Escherichia coli by integrant expression of crtEBI gene and deletion of aceE and gdhA

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 739-749页

作者： Xiaoqing Hu Mao Cui Xiaoyuan Wang State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Laboratory on Food Safety Jiangnan UniversityWuxi 214122China

As a bright red carotenoid pigment found in tomatoes and other red fruits,lycopene was efficiently produced by Escherichia coli transformed with the genes involving in lycopene *** previous work showed that ***ΔwaaC andΔwaaF with higher permeability of outer membrane were better chassis for lycopene ***,further work needed to improve lycopene synthesis in the aforementioned *** the current study,the exogenous crtEBI genes from *** 14067 were first integrated into the chromosome ofΔwaaC andΔ*** toΔwaaC/pWSK29-crtEBI andΔwaaF/pWSK29-crtEBI(4.19 and 4.20 mg/g lycopene respectively),ΔwaaC lacZ::crtEBI(CWC01)andΔwaaF lacZ::crtEBI(CWF01)produced higher lycopene levels at 16.14 mg/g and 15.81 mg/g,***,the individual and combinational deletion of aceE and gdhA was conducted in CWC01 and CWF01,*** double knock-out strains CWC04 and CWF04 showed the improved yield at 19.65 mg/g and 22.24 mg/g,***,the four genes involving in MEP pathway(dxs,dxr,ispA and idi)were further *** highest lycopene yield was achieved at 25.82 mg/g by CWF04/pACYC184-dxs^(E289G)-dxr^(K37N,K217N)-*** current study showed that ***ΔwaaC andΔwaaF were optimal chassis for ambitious metabolic modification to produce lycopene.

关键词： lycopene Escherichia coli waaC waaF