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Immunomodulatory activity of a lupane triterpenoid ester isolated from the eastern Nigeria mistletoe,Loranthus micranthus(Linn)

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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 514-522页

作者： Omeje Edwin Ogechukwu Osadebe Patience Ogoamaka Nworu Chukwuemeka Sylvester Akira Kawamura Peter Proksch Department of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical SciencesUniversity of Nigeria410001NsukkaNigeria Department of Pharmacology and Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria410001NsukkaNigeria Department of Chemistry Hunter College of CUNYThe City University of New YorkU.S.A Department of Pharmaceutical Biology Heinrich-Hein UniversityDusseldorfGermany

Objective:To provide further evidence for the ethnomedicinal use of the Eastern Nigeria mistletoe,Loranthus micranthus(***),as an ***:Solvent fractions from the crude extract of the mistletoe plant was obtained and screened by the cell mediated delayed type hypersensitivity reaction(DTHR) model in *** the immunomodulatory potentials of a major lupane triterpenoid ester isolated from an active hexane fraction of the Eastern Nigeria mistletoe was *** lupeol-based triterpenoid esters: 7β15α-dihydroxyl-lup-20(29)-ene-3β-palmitate(Ⅰ),7β,15α-dihydroxyl-lup-20(29)- ene-3β-stearate(Ⅱ) and 7β,15α-dihydroxyl-lup-20(29)-ene-3β-decadecanoate(Ⅲ) were isolated from the plant leaves epiphyting on a local kola nut tree and were characterized. Compound 1 was subjected to cell proliferation studies using C57H1/6 splenocvtes at three dose levels(5.25 and 100μg/mL) in presence of ***,the effect of this compound on IL-8 receptor expression was evaluated at three doses(1,5 and 10μg/mL) using the real time polymerase chain reaction ***:This triterpenoid ester produced some enhancement of the splenocytes at the tested doses but at doses higher than 5μg/mL caused inhibition of the IL-8 receptor ***:The present findings support the ethnomedicinal use of the Eastern Nigeria Mistletoe in the management of diseases affecting the immune *** trilerpenoid(s) have some immunomodulatory abilities on splenocytes and IL-8 receptors and may partly account lor the overall immunomodulatory activity of this plant.

关键词： lupane triterpenoid Loranthus micranthus Eastern Nigeria mistletoe Interleukin-8 Cell proliferation Anti-inflammatory

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