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Deep Learning ResNet101 Deep Features of Portable Chest X-Ray Accurately Classify COVID-19 lung infection

Computers, Materials & Continua 2023年第6期75卷 5213-5228页

作者： Sobia Nawaz Sidra Rasheed Wania Sami Lal Hussain Amjad Aldweesh Elsayed Tag eldin Umair Ahmad Salaria Mohammad Shahbaz Khan Basic Health Unit Sumra Lodhran59320Pakistan Basic Health Unit 20-G ChishtianBahawalnagar62300Pakistan Doctor’s Hospital Lahore54590Pakistan Department of Computer Science&IT Neelum CampusThe University of Azad Jammu and KashmirAthmuqam13230Azad KashmirPakistan Department of Computer Science&IT King Abdullah CampusThe University of Azad Jammu and KashmirMuzaffarabad13100Azad KashmirPakistan College of Computer science and information technology Shaqra UniversityShaqra15273Saudi Arabia Faculty of Engineering and Technology Future University in EgyptNew Cairo11835Egypt Department of Electrical Engineering University of Azad Jammu and KashmirChehla CampusMuzaffarabad13100Azad KashmirPakistan Department of Electrical Engineering Mirpur University of Science&TechnologyMirpurMuzaffarabad10250Azad KashmirPakistan Children’s National Hospital 111 Michigan AVE NWWashingtonDC20854USA

This study is designed to develop Artificial Intelligence(AI)based analysis tool that could accurately detect COVID-19 lung infections based on portable chest x-rays(CXRs).The frontline physicians and radiologists suffer from grand challenges for COVID-19 pandemic due to the suboptimal image quality and the large volume of *** this study,AI-based analysis tools were developed that can precisely classify COVID-19 lung *** available datasets of COVID-19(N=1525),non-COVID-19 normal(N=1525),viral pneumonia(N=1342)and bacterial pneumonia(N=2521)from the Italian Society of Medical and Interventional Radiology(SIRM),Radiopaedia,The Cancer Imaging Archive(TCIA)and Kaggle repositories were taken.A multi-approach utilizing deep learning ResNet101 with and without hyperparameters optimization was ***,the fea-tures extracted from the average pooling layer of ResNet101 were used as input to machine learning(ML)algorithms,which twice trained the learning *** ResNet101 with optimized parameters yielded improved performance to default *** extracted features from ResNet101 are fed to the k-nearest neighbor(KNN)and support vector machine(SVM)yielded the highest 3-class classification performance of 99.86%and 99.46%,*** results indicate that the proposed approach can be bet-ter utilized for improving the accuracy and diagnostic efficiency of *** proposed deep learning model has the potential to improve further the efficiency of the healthcare systems for proper diagnosis and prognosis of COVID-19 lung infection.

关键词： COVID-19 deep learning(DL) lung infection convolutional neural network(CNN)

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IL-27/IL-27R promotes host defense against chlamydial lung infection by suppressing neutrophils recruitment mediated by Th17

IL-27/IL-27R promotes host defense against chlamydial lung i...

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第十三届全国免疫学学术大会

作者： Xiaoyu zha Gaoju Pang Lida Sun Sai Qiao Wenhao Niu Juyou Liang Lu Tan Hong Zhang Tengli Liu Huili Zhao Yue Wang Hong Bai Tianjin Medical University

Interleukin-27, a heterodimeric cytokine of IL-12 family, composed of Epstein-Barr virus-induced gene 3(EBI3) and p28, has diverse influences on the immune response. In this study, we identified the role of IL-27/IL-27 R in host defense against Chlamydia lung infection and further investigated the influence of IL-27/IL-27 R on Th1 and Th17 cell responses as well as neutrophils recruitment. Our data showed that mRNA expression of IL-27(EBI3) and IL-27 R(WSX-1) were significantly induced after Cm infection especially on day 7 post-infection(p.i.) in wild type mice. Mice with WSX-1 knockout(WSX-1mice) showed higher severity of the disease with greater body weight loss, more chlamydia growth and more severe inflammatory cell infiltration in lungs compared with WT mice. Th1 cell responses, which played a protective role in Cm infection, was significantly weaken in lungs on day 7 p.i. and day 14 p.i. whereas Th17 cell responses, which can promote neutrophil recruitment, was dramatically enhanced in lungs on day 7 p.i. and day 14 p.i. in WSX-1mice compared with WT mice. Neutrophils in lung were also increased on day 7 p.i. and day 14 p.i. in WSX-1mice compared to WT mice which was in accordant with upregulated mRNA expression of chemokines and cytokines of neutrophils including IL-17, TNFα, IL-6 and CXCR2. To further confirm that severe disease condition in WSX-1mice was caused by increased IL-17 in lungs, we found that WSX-1mice injected with mouse IL-17/IL-17 A-blocking antibody on the day before infection, day 2 p.i. and day 4 p.i. showed improved disease status in the aspects of body weight change, chlamydia growth and neutrophil recruitment in lungs compared to those without IL-17 blocking. Taken together, we concluded that IL-27/IL-27 R plays a protective role in host defense against Chlamydia lung infection by suppressing neutrophils recruitment mediated by Th17.

关键词： Chlamydia lung infection IL-27/IL-27R Th17 Neutrophil

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Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model

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Zoological Research 2020年第6期41卷 621-631页

作者： Yan Liang Heng Li Jing Li Ze-Ning Yang Jia-Li Li Hui-Wen Zheng Yan-Li Chen Hai-Jing Shi Lei Guo Long-Ding Liu Institute of Medical Biology Chinese Academy of Medical SciencesKunmingYunnan 650118China

Understanding the pathogenesis of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and clarifying antiviral immunity in hosts are critical aspects for the development of vaccines and *** are frequently used to generate animal models of infectious diseases due to their convenience and ability to undergo genetic ***,normal adult mice are not susceptible to ***,we developed a viral receptor(human angiotensin-converting enzyme 2,hACE2)pulmonary transfection mouse model to establish SARS-CoV-2 infection rapidly in the mouse *** on the model,the virus successfully infected the mouse lung 2 days after *** RNA/protein,innate immune cell infiltration,inflammatory cytokine expression,and pathological changes in the infected lungs were observed after *** studies indicated that neutrophils were the first and most abundant leukocytes to infiltrate the infected lungs after viral *** addition,using infected CXCL5-knockout mice,chemokine CXCL5 was responsible for neutrophil ***5 knockout decreased lung inflammation without diminishing viral clearance,suggesting a potential target for controlling pneumonia.

关键词： SARS-CoV-2 Mouse model lung infection ACE2 Neutrophil CXCL5

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A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection

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Cellular & Molecular Immunology 2011年第6期8卷 462-468页

作者： Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu Department of Pathology The University of Hong KongHong KongChina Department of Microbiology The University of Hong KongHong KongChina Center of infection and Immunology The University of Hong KongHong KongChina

Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the *** there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus *** this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type ***,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO *** with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in *** together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice.

关键词： B cell H5N1 influenza virus IL-17 lung infection

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COVID-19 Severity Prediction Using Enhanced Whale with Salp Swarm Feature Classification

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Computers, Materials & Continua 2022年第7期72卷 1685-1698页

作者： Nebojsa Budimirovic E.Prabhu Milos Antonijevic Miodrag Zivkovic Nebojsa Bacanin Ivana Strumberger K.Venkatachalam Singidunum University Belgrade11000Serbia Department of Electronics and Communication Engineering Amrita School of EngineeringAmrita Vishwa VidyapeethamCoimbatore641112India Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic

Computerized tomography(CT)scans and X-rays play an important role in the diagnosis of COVID-19 and *** the basis of the image analysis results of chest CT and X-rays,the severity of lung infection is monitored using a *** researchers have done in diagnosis of lung infection in an accurate and efficient takes lot of time and *** overcome these issues,our proposed study implements four cascaded ***,for pre-processing,a mean filter is ***,texture feature extraction uses principal component analysis(PCA).Third,a modified whale optimization algorithm is used(MWOA)for a feature selection *** severity of lung infection is detected on the basis of age ***,image classification is done by using the proposed MWOAwith the salp swarm algorithm(MWOA-SSA).MWOA-SSA has an accuracy of 97%,whereas PCA and MWOA have accuracies of 81%and 86%.The sensitivity rate of the MWOA-SSA algorithm is better that of than PCA(84.4%)and MWOA(95.2%).MWOA-SSA outperforms other algorithms with a specificity of 97.8%.This proposed method improves the effective classification of lung affected images from large datasets.

关键词： PCA WOA CT-image lung infection COVID-19

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Rapidly progressing primary pulmonary lymphoma masquerading as lung infectious disease:A case report and review of the literature

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World Journal of Clinical Cases 2021年第16期9卷 4016-4023页

作者： Jin-Hong Jiang Chun-Lai Zhang Qin-Li Wu Yong-Hua Liu Xiao-Qiu Wang Xiao-Li Wang Bing-Mu Fang Department of Hematology Lishui City People's HospitalLishui 323000Zhejiang ProvinceChina Department of Ultrasonography Lishui City People's HospitalLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui City People's HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Primary anaplastic large cell lymphoma of the lung represents a diagnostic challenge due to diverse manifestations and non-specific radiological findings,particularly in cases that lack extra-pulmonary manifestations and lung *** SUMMARY A 40-year-old woman presented with a 6-d history of fever,dry coughing,and *** white blood cell count was 20100/mm3 with 90%***2 was 60 mmHg and SaO2 was 90%when breathing ambient *** computed tomography(CT)identified a solid nodule,15 mm in diameter,with a poorly defined boundary in the upper right lung,and several smaller solid nodules throughout both *** artery CT and subsequent bedside X-ray showed diffuse patchy shadows throughout both *** cultures of blood samples and alveolar lavage failed to identify any *** to the mismatch between clinical and imaging features,we conducted a bone marrow biopsy,and the results showed proliferation along all three lineages but no atypical or malignant *** patient received empirical antibacterial,antiviral,and antifungal treatments,as well as *** patient’s condition deteriorated rapidly despite *** patient died 6 d after hospitalization due to respiratory ***-mortem lung biopsy failed to show inflammation but identified widespread infiltration of alveolar septum by anaplastic lymphoma kinase(ALK)-positive anaplastic *** ALK-positive anaplastic large cell lymphoma could present as a primary pulmonary disease without extra-pulmonary manifestations.

关键词： Primary anaplastic large cell lymphoma lungs Anaplastic lymphoma kinase lung infection Differential diagnosis Case report

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Treatment failure in a patient infected with Listeria sepsis combined with latent meningitis:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10565-10574页

作者： Gui-Xian Wu Jian-Ya Zhou Wei-Jun Hong Jing Huang Shuang-Quan Yan Department of Respiratory and Critical Care Medicine Taizhou Hospital of Zhejiang ProvinceZhejiang UniversityEnze HospitalTaizhou Enze Medical Center(Group)Taizhou 318050Zhejiang ProvinceChina Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Neurology Department Taizhou Hospital of Zhejiang ProvinceZhejiang UniversityEnze HospitalTaizhou Enze Medical Center(Group)Taizhou 318050Zhejiang ProvinceChina

BACKGROUND Listeria is a food-borne disease,which is rarely prevalent in the normal population;it mostly occurs in pregnant women,newborns,immunodeficiency patients,and the *** main manifestations of this disease in patients include sepsis,meningitis,etc,and the mortality rate remains high,although the onset of meningitis is relatively *** SUMMARY A 75-year-old man presented with a fever for 1 wk and was admitted to the hospital for diagnosis and management of a lung *** condition improved after receiving anti-infective treatment for 2 ***,soon after he was discharged from the hospital,he developed fever again,and gradually developed various neurological symptoms,impaired consciousness,and stiff ***,through the cerebrospinal fluid metagenomic testing and blood culture,the patient was diagnosed with Listeria monocytogenes meningitis and *** patient died after being given active treatment,which included penicillin application and invasive respiratory *** This case highlights the ultimate importance of early identification and timely application of the various sensitive antibiotics,such as penicillin,vancomycin,meropenem,***,for high-risk populations with unknown causes of fever,multiple blood cultures,timely cerebrospinal fluid examination,and metagenomic detection technology can assist in confirming the diagnosis quickly,thereby guiding the proper application of antibiotics and improving the prognosis.

关键词： Listeria monocytogenes Encephalitis Sepsis lung infection Case report

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Teicoplanin combined with conventional vancomycin therapy for the treatment of pulmonary methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis infections

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World Journal of Clinical Cases 2021年第34期9卷 10549-10556页

作者： Wei Wu Min Liu Jia-Jing Geng Mei Wang Laboratory Medicine Bejing Tongren HospitalCapital Medical UniversityBeijing 100176China Department of General Practice The Community Health Services Center in LumenBeijing 100080China

BACKGROUND Vancomycin and teicoplanin are both antibiotics that have significant antimicrobial effects on Gram-positive *** To explore the value of teicoplanin combined with conventional(vancomycin only)anti-infective therapy for the treatment of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis pulmonary *** A total of 86 patients with methicillin-resistant Staphylococcus aureus or methicillin-resistant Staphylococcus epidermidis pulmonary infections,treated in our hospital between January 2018 and February 2020,were assigned to the study and control groups using a random number table method,with 43 patients in each *** control group received conventional treatment(vancomycin),and the study group received both teicoplanin and conventional *** following indicators were assessed in both groups:the time required for symptom relief,treatment effectiveness,serum levels of inflammatory factors(procalcitonin,interleukin-1β,tumor necrosis factor-α,C-reactive protein),clinical pulmonary infection scores before and after treatment,and the incidence of adverse *** Patients in the study group were observed to have faster cough and expectoration resolution,white blood cell count normalization,body temperature normalization,and rales disappearance than patients in the control group(all Pinfection scores were similar among the patients in both ***,the post-treatment serum levels of procalcitonin,interleukin-1β,tumor necrosis factor-α,and C-reactive protein as well as the clinical pulmonary infection scores were significantly lower in the study group than in the control group(P<0.05).There was no significant difference in the incidence o

关键词： Vancomycin Teicoplanin Methicillin-resistant Staphylococcus aureus Methicillin-resistant Staphylococcus epidermidis lung infection

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利用双金属纳米颗粒协同提高抗生素对耐碳青霉烯类细菌的疗效

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Science China Materials 2023年第7期66卷 2885-2892页

作者：赵晓慧刘绍琴蒋兴宇 School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen 518055China

细菌对碳青霉烯类抗生素耐药性的日益增加,已成为一个备受关注的问题.联合治疗是应对耐药细菌感染的有效策略.在本研究中,双金属纳米颗粒(AuRh NPs)与小分子抗生素(亚胺培南)具有协同抗菌作用,它们通过增加细菌胞内的活性氧水平和增强... 详细信息

细菌对碳青霉烯类抗生素耐药性的日益增加,已成为一个备受关注的问题.联合治疗是应对耐药细菌感染的有效策略.在本研究中,双金属纳米颗粒(AuRh NPs)与小分子抗生素(亚胺培南)具有协同抗菌作用,它们通过增加细菌胞内的活性氧水平和增强细菌膜的渗透性表现出优异的抗菌效果.特别地,联合治疗恢复了亚胺培南对耐碳青霉烯类肺炎克雷伯菌(CRKP)的疗效,最低抑菌浓度降低了128倍.在治疗肺部感染时,AuRh NPs与亚胺培南联合使用能更有效地抑制CRKP感染,与单独使用亚胺培南或AuRh NPs实验组相比,小鼠的存活率提升了50%.体外和体内安全性研究表明,AuRh NPs与亚胺培南联合使用没有明显的毒性.这种联合疗法为耐药细菌感染提供了有效的治疗策略.

关键词： antibiotic resistance combination therapy bimetallic nanoparticles antibiotics lung infection

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Prolonged course of Paxlovid administration in a centenarian with COVID-19:A case report

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World Journal of Radiology 2024年第9期16卷 489-496页

作者： Yi-Xue Zhang Juan Tang Dan Zhu Chun-Yan Wu Mei-Lan Liang Yuan-Tao Huang Department of Healthcare Haikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikou 570208Hainan ProvinceChina Department of Healthcare Hainan Chengmei HospitalHaikou 570000Hainan ProvinceChina

BACKGROUND According to the population statistics in 2023,there were 110000 people aged over 100 years in China,and the experience of using Paxlovid(nirmatrelvir/ritonavir)for centenarians is particularly *** article reports our experience of using Paxlovid in a centenarian with the novel coronavirus disease 2019(COVID-19)*** SUMMARY A 103-year-old female with mild COVID-19 and renal insufficiency was given sufficient Paxlovid for 2 days and a half dose for 3 *** treatment,the patient was complicated with lung infection and heart failure,and nucleic acid remained *** expert consultation,a full dose of Paxlovid was given again on the 9th day of admission for 2 days and a half dose for 3 ***,anti-heart failure and antibiotics were administered;the heart failure and pulmonary infection were ***,on the 33^(th) day of admission,nucleic acid turned negative,body temperature returned to normal,cough and sputum,fatigue,poor appetite and other symptoms basically *** patient was given Paxlovid via nasal feeding for 2 courses without deterioration of liver and kidney function,diarrhea,nausea and vomiting,myalgia,chest tightness and other side effects,and was discharged from hospital with good *** This case suggests that Paxlovid can be used cautiously in centenarians with renal insufficiency and two courses of treatment can be considered in patients with persistent positive nucleic acid.

关键词： COVID-19 Paxlovid Centenarians Renal insufficiency Heart failure lung infection Case report

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