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lung squamous cell carcinoma combined with tuberculous pleurisy

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Chinese Medical Journal 2012年第20期125卷 3755-3756页

作者： ZHANG Yi YAO Shu-yang LI Yuan-bo ZHANG Jian Department of Thoracic Surgery Xuanwu HospitalLung Cancer CenterCapital Medical UniversityBeijing 100050China

A58-year old male patient was admitted to our .hospital with repeated coughing, expectoration withblood in the sputum for more than 10 months, bilateral wrists and ankles with pain and afternoon low fever, chest tightness and shortness of breath in the latest one month. The patient had a history of joint pain for more than 3 years without special treatment. He had a smoking history for more than 30 years with 10 cigarettes a day. He had no family tumor history. Physical examination： T 38.5℃, P 100/min, R 22/min, blood pressure （BP） 107/77 mmHg; the double upper fingers visible clubbing, bilateral supraclavicular lymph node not feelable, left inferior pulmonary respiratory sounds disappeared, and wet and dry sounds not heard.

关键词： lung squamous cell carcinoma diagnosis tuberculous pleurisy surgery

Prediction of Tumor Microenvironment Characteristics and Treatment Response in lung squamous cell carcinoma by Pseudogene OR7E47P-related Immune Genes

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Current Medical Science 2023年第6期43卷 1133-1150页

作者： Ya-qi ZHAO Hao-han ZHANG Jie WU Lan LI Jing LI Hao ZHONG Yan JIN Tian-yu LEI Xin-yi ZHAO Bin XU Qi-bin SONG Jie HE Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China Department of Medical Oncology First Affiliated Hospital of Kunming Medical UniversityKunming650000China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100032China

Objective Pseudogenes are initially regarded as nonfunctional genomic sequences,but some pseudogenes regulate tumor initiation and progression by interacting with other genes to modulate their transcriptional *** receptor family 7 subfamily E member 47 pseudogene(OR7E47P)is expressed broadly in lung tissues and has been identified as a positive regulator in the tumor microenvironment(TME)of lung adenocarcinoma(LUAD).This study aimed to elucidate the correlation between OR7E47P and tumor immunity in lung squamous cell carcinoma(LUSC).Methods Clinical and molecular information from The Cancer Genome Atlas(TCGA)LUSC cohort was used to identify OR7E47P-related immune genes(ORIGs)by weighted gene correlation network analysis(WGCNA).Based on the ORIGs,2 OR7E47P clusters were identified using non-negative matrix factorization(NMF)clustering,and the stability of the clustering was tested by an extreme gradient boosting classifier(XGBoost).LASSO-Cox and stepwise regressions were applied to further select prognostic ORIGs and to construct a predictive model(ORPScore)for *** Botling cohorts and 8 immunotherapy cohorts(the Samstein,Braun,Jung,Gide,IMvigor210,Lauss,Van Allen,and Cho cohorts)were included as independent validation *** OR7E47P expression was positively correlated with immune cell infiltration and enrichment of immune-related pathways in LUSC.A total of 57 ORIGs were identified to classify the patients into 2 OR7E47P clusters(Cluster 1 and Cluster 2)with distinct immune,mutation,and stromal *** to Cluster 1,Cluster 2 had more infiltration by immune and stromal cells,lower mutation rates of driver genes,and higher expression of immune-related *** clustering performed well in the internal and 5 external validation *** on the 7 ORIGs(HOPX,STX2,WFS,DUSP22,SLFN13,GGCT,and CCSER2),the ORPScore was constructed to predict the prognosis and the treatment *** addition,the ORPScore was a bette

关键词： pseudogene olfactory receptor family 7 subfamily E member 47 pseudogene-related immune gene tumor microenvironment immunotherapy lung squamous cell carcinoma

Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in lung squamous cell carcinoma

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Current Medical Science 2024年第2期44卷 309-327页

作者： Xiao-jun WANG Jia-ping CHEN Xin-wei QIAO Wang-yang MENG Yang-wei WANG Yun-chong MENG Rong ZHAO Wei LIN Yong-de LIAO Han XIAO Pei-yuan MEI Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:lung squamous cell carcinoma(LUSC)is associated with a low survival *** suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and ***,a comprehensive analysis of their role in LUSC is *** study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of ***:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO ***,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in *** core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for *** specimens were examined by immunohistochemical analysis to confirm the diagnostic value in ***,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was ***:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for ***10 showed a significant positive correlation with immune cell infiltration and immune checkpoint ***:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study

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Cancer Communications 2022年第1期42卷 3-16页

作者： Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou Department of Medical Oncology Shanghai Pulmonary Hospital&Thoracic Cancer InstituteTongji University School of MedicineShanghai 200433P.R.China Department of Chemotherapy Anhui Provincial HospitalHefeiAnhui 230001P.R.China Department of Oncology Fuzhou Pulmonary Hospital of FujianFuzhouFujian 350008P.R.China Department of Respiratory Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Department of Respiration Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030P.R.China Cancer Center Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Department of Medical Oncology the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230032P.R.China Department of Respiration Henan Cancer HospitalZhengzhouHenan 450008P.R.China Department of Medical Oncology the Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000P.R.China Department of Medical Oncology Hunan Cancer HospitalChangshaHunan 410013P.R.China Department of Pulmonary and Critical Care Medicine the First Affiliated Hospital of Wenzhou Medical CollegeShangcai villageWenzhouZhejiang 325000P.R.China Department of Medical Oncology the First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006P.R.China Department of Medical Oncology Xiang Yang Central HospitalXiangyangHubei 441021P.R.China Department of Medical Oncology Renmin Hospital of Wuhan UniversityWuhanHubei 430060P.R.China Department of Respiration General Hospital of Eastern Theater Command of Chinese People’s Liberation ArmyNanjingJiangsu 210002P.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiang 310022P.R.China Cancer Center the First Bethune Hospital of Jilin UniversityChangchunJilin 130021P.R.China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081P.R.China Department of Respiratory Medicine Weifang People’s HospitalWeifangShandong

Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale ***,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic ***:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial *** primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety *** explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP *** correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary ***:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)*** median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)le

关键词： chemotherapy cisplatin clinical trial gemcitabine liposomal paclitaxel(Lipusu) locally advanced lung squamous cell carcinoma metastatic multicenter plasma cytokines

Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma

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Precision Clinical Medicine 2024年第2期7卷 109-121页

作者： Guo Li Lu Chen Hua Bai Li Zhang Jie Wang Weimin Li CAMS Key Laboratory of Translational Research on lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences Peking Union Medical CollegeBeijing 100021China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengdu 610041China The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengdu 610041China

Background:lung squamous cell carcinoma(Lusc)lacks effective targeted therapies and has a poor *** of squalene epoxidase(SQLE)has been implicated in metabolic disorders and ***,the role of SQLE as a monooxygenase involved in ***:We analyzed the expression and prognosis of lung adenocarcinoma(LUAD)and LUSC samples from GEO and TCGA *** proliferative activity of the tumors after intervention of SQLE was verified by cell and animal ***-1 assay,flow cytometry,and Western blot were used to show changes in apoptosis after intervention of *** cytometry and fluorescence assay of ROs levels were used to indicate oxidative stress ***:We investigated the unique role of SQLE expression in the diagnosis and prognosis prediction of *** of SQLE or treatment with the SQLE inhibitor terbinafine can suppress the proliferation of LUsC cells by inducing apoptosis and reactive oxygen species ***,depletion of SQLE also results in the impairment of lipid peroxidation and ferroptosis resistance such as upregulation of glutathione peroxidase ***,prevention of SQLE in synergy with glutathione peroxidase 4 inhibitor RSL3 effectively mitigates the proliferation and growth of ***:Our study indicates that the low expression of sQLE employs adaptive survival through regulating the balance of apoptosis and ferroptosis *** future,the combinational therapy of targeting sQLE and ferroptosis could be a promising approach in treating LUSC.

关键词： lung squamous cell carcinoma squalene epoxidase terbinafine RoS ferroptosis

Mediastinal lymph node metastasis (N2 disease) based on the lobar location of lung squamous cell carcinoma

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当代医药论丛 2011年第11期 13-15页

作者： HE Zheng-fu1,ZHANG Wei-min1,ZHENG Wei-lian2,LI Zhi-jun1,WANG Yong-qing3,XU He-yun1(1.Department of Cardiothoracic Surgery,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou,310016,P.R.China.2.Department of Radioology,College of Medicine,Zhejiang University,Hangzhou,310016,P.R.China.3.Department of Cardiothoracic Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,310016P.R.China.)

Aims:To explore the rule of N2 disease based on the lobar location of lung squamous cell ***:A retrospective review of CT and clinical data of 438 patients with lung squamous cell carcinoma had been *** statistic the rate of N2 disease of different lobar location of lung squamous cell ***:The incidence and location of N2 disease of the 438 patients based on the location of the primary squamocellular carcinoma was as follows:for right upper lobe cancers,25% had N2 disease,most commonly in the 4R(36%) ;16% cases of right middle lobe had N2 and most commonly in the 4R(50%) and the 7th station(50%) ;30% cases of right lower lobe mass had N2 diseases and,most commonly in the 4R(31%) and the7th station(34%) ;left upper lobe,had 21% N2,most commonly in the 6th station(50%) ;and left lower lobe,24%,most commonly in the 7th station(43%) .Skip metastases(no N1,but N2) was appeared at left upper lobe lesions *** with right-sided cancers have the similar incidence to have N2 disease(71/271,26%) as comparing with patients who had left-sided lesions(36/167,22%) (P>0.05) .Incidence of N2 diseases in right low lobe was more higher than other lobe,but have no significant difference compared to that of right upper lobe and left low lobe(P>0.05) .Incidence of N2 diseases in right middle lobe was the lowest when compared to that of other lobe(Plung squamous cell *** location of lymph nodes metastasis had important rule in the classification and surgical dissection of lung squamous cell carcinoma.

关键词： lung squamous cell carcinoma metastasis N2 disease CT

Impact of Preoperative Serum Tumor Markers in Patients with lung squamous cell carcinoma

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Advances in lung Cancer 2021年第3期10卷 48-55页

作者： Masaki Tomita Shoei Kuroki Tomoka Hamahiro Ryo Maeda Takanori Ayabe Department of Thoracic and Breast Surgery Faculty of Medicine University of Miyazaki Kiyotake Miyazaki Japan

Background: Several previous researchers have investigated the prognostic value of serum tumor markers, especially carcinoembryonic antigen (CEA). Only a limited number of studies reported the usefulness of serum tumor markers for lung squamous cell carcinoma (SQ). We aimed to examine the significance of serum tumor markers for lung SQ. Methods: Eighty-five lung SQ patients who underwent surgery and followed more than 5-year were included. The ratios of 5-year survivors to all patients in groups with several clinicopathologic factors, including tumor markers, were compared. We also compared the clinicopathologic factors between central type and peripheral type SQ. Results: The majority of patients were male gender and current/ former smokers. Age, pN status, cytokeratin-19 fragment (CYFRA 21-1), squamous cell carcinoma antigen (SCC), and comorbid interstitial pneumonia (IP) were associated with the ratio of 5-year survivors significantly. When patients were compared based on tumor location, high p-stage and CYFRA 21-1 were related to central type SQ. Conclusion: Both SCC and CYFRA 21-1 appeared to be useful prognostic markers for patients with lung SQ. Furthermore, CYFRA 21-1 was related to central type SQ.

关键词： lung squamous cell carcinoma Cytokeratin-19 Fragment squamous cell carcinoma Antigen

Mediastinal lymph node metastasis (N2 disease) based on the lobar location of lung squamous cell carcinoma

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求医问药（下半月刊） 2011年第11期9卷 13-15页

作者： HE Zheng-fu ZHANG Wei-min ZHENG Wei-lian LI Zhi-jun WANG Yong-qing XU He-yun Department of Cardiothoracic Surgery Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou310016P.R.China Department of Radioology College of MedicineZhejiang UniversityHangzhou310016P.R.China Department of Cardiothoracic Surgery First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310016P.R.China.

关键词： lung squamous cell carcinoma metastasis N2 disease CT

Mutant p53/miR-223-3p feedback loop regulates proliferation and migration through targeting and interfering with the intracellular localization of p27kip1 in lung squamous cell carcinoma

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Mutant p53/miR-223-3p feedback loop regulates proliferation ...