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Engineering of Reversible luminescent probes for Real-Time Intravital Imaging of Liver Injury and Repair

CCS Chemistry 2022年第1期4卷 356-368页

作者： Xiao Liu Linhui He Xiangyang Gong Yue Yang Dan Cheng Juanjuan Peng Lu Wang Xiao-Bing Zhang Lin Yuan State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082 State Key Laboratory of Natural Medicines School of Basic Medical Sciences and Clinical PharmacyChina Pharmaceutical UniversityNanjingJiangsu 211198 Department of Chemical Biology Max Planck Institute for Medical ResearchHeidelberg 69120

As the major organ for drug metabolism and detoxification,the liver is prone to damage and severely impaired *** treatment of liver diseases is based on a clear understanding of the process underlying liver injury and ***,intravital real-time imaging of liver injury and repair is still limited due to the lack of in vivo reversible visualization *** this end,we proposed a rational design strategy for the development of a reversible upconversion luminescence nanoprobe that allows real-time and in vivo imaging of liver injury and repair *** a proof of concept,we first developed a small molecule probe NB3 which can reversibly respond to related analytes of early liver injury[peroxynitrite(ONOO−)]and liver repair[glutathione(GSH)].The small molecule probe was then integrated with a core–shell upconversion nanoparticle to form a sophisticated *** with traditional small molecule probes,this nanoprobe exhibited a higher selectivity to ONOO−,longer retention time in liver,and wider dynamic response range to GSH after oxidation by ONOO−.The novel nanoprobe facilitated the successful monitoring and discrimination among the different degrees of liver injury and repair in a mouse model.

关键词： luminescent probes liver injury and repair fluorescence imaging peroxynitrite GSH

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Observing antimicrobial process with traceable gold nanodusters

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Nano Research 2021年第4期14卷 1026-1033页

作者： Kaiyuan Zheng Magdiel I.Setyawati David Tai Leong Jianping Xie Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Understanding the interaction of nanomaterials with biological systems has always been of high concern and *** emerging type of nanomaterials,ultrasmall metal nanoclusters(NCs,luminescent gold(Au)NCs were used as traceable antimicrobial agents to study their interactions with the bacteria and tofurther understand their underlining antimicrobial *** is shown for the first time that the Au NCs would first attach on the bacterial membrane,penetrate,and subsequently accumulate inside the ***,the internalized Au NCs would induce reactive oxygen species(ROS)generation and damage the bacterial membrane,resulting in the leakage of bacterial contents,which can finally kill the *** Au NCs(or other metal NCs)provide a promising platform to study the antimicrobial mechanisms as well as other fundamentals on the interfacing of functional nanomaterials with the biological systems,further increasing their acceptance in various biomedical applications.

关键词： metal nanoclusters gold nancx^lusters antimicrobial agents luminescent probes bioimaging

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Recent progress on lanthanide complexes/clay minerals hybrid luminescent materials

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Journal of Rare Earths 2022年第9期40卷 1360-1370,I0001页

作者： Ga Zhang Lefu Mei Junjie Ding Ke Su Qingfeng Guo Guocheng Lv Libing Liao Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing 100083China School of Gemmology China University of GeosciencesBeijing 100083China

The unique luminescent performance of lanthanide complexes/clay minerals hybrid materials has been fascinating many researchers for recent *** not only retains the excellent luminescent characteristics of lanthanide complexes but also improves the poor stability of the *** this article,we introduce the luminescence mechanism of lanthanide complexes and point out the necessity of their combination with clay *** the analysis of the structure and interlayer environment differences of 1:1-type and 2:1-type clay minerals,the intercalation methods(covalent grafting and ion exchange)appropriate for different clay minerals are summarized with *** on the luminescence characteristics of the hybrid materials,the applications of these materials as luminescent probes in recognition of specific metal cations and molecules,detection of pH value,and temperature are ***,the current problems in the preparation of lanthanide complexes/clay minerals hybrid luminescent materials and shortcomings that need improvement in their performance are analyzed,and the application prospect is forecast.

关键词： Luminescence Hybrid materials Lanthanide complexes Clay minerals luminescent probes Rare earths

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