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Plaque imaging with CT coronary angiography:Effect of intra-vascular attenuation on plaque type classification

World Journal of Radiology 2012年第6期4卷 265-272页

作者： Erica Maffei Chiara Martini Teresa Arcadi Alberto Clemente Sara Seitun Alessandra Zuccarelli Tito Torri Nico R Mollet Alexia Rossi Onofrio Catalano Giancarlo Messalli Filippo Cademartiri Cardiovascular Imaging Unit Giovanni XXIII Hospital31050 Monastier di TrevisoTrevisoItaly Department of Radiology Academic Hospital of Parma43100 ParmaItaly Department of Radiology Ospedale di Carrara54033 CarraraItaly Department of Radiology Erasmus Medical Center University3015 CE RotterdamThe Netherlands Filippo Cademartiri Department of Radiology SDN FoundationIRCCS80143 NaplesItaly Department of Radiology Erasmus Medical Center University3015 CE RotterdamThe Netherlands

AIM: To assess the attenuation of non-calcified atherosclerotic coronary artery plaques with computed tomography coronary angiography (CTCA). METHODS: Four hundred consecutive patients underwent CTCA (Group 1: 200 patients, Sensation 64 Cardiac, Siemens; Group 2: 200 patients, VCT GE Healthcare, with either Iomeprol 400 or Iodixanol 320, respectively) for suspected coronary artery disease (CAD). CTCA was performed using standard protocols. Image quality (score 0-3), plaque (within the accessible non-calcified component of each non-calcified/mixed plaque) and coronary lumen attenuation were measured. Data were compared on a per-segment/per-plaque basis. Plaques were classified as fibrous vs lipid rich based on different attenuation thresholds. A P lumen attenuation was 367 ± 85 Hounsfield units (HU) in Group 1 and 327 ± 73 HU in Group 2 (P < 0.05); non-calcified plaque attenuation was 48 ± 23 HU in Group 1 and 39 ± 21 HU in Group 2 (P < 0.05). Overall signal to noise ratio was 15.6 ± 4.7 in Group 1 and 21.2 ± 7.7 in Group 2 (P < 0.01). CONCLUSION: Higher intra-vascular attenuation modifies significantly the attenuation of non-calcified coronary plaques. This results in a more difficult characterization between lipid rich vs fibrous type.

关键词： Computed tomography coronary angiography Coronary artery plaque Plaque characterization Contrast material lumen enhancement

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