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low-magnitude high-frequency vibration reduces prostate cancer growth and extravasation in vitro

Mechanobiology in Medicine 2024年第4期2卷 83-96页

作者： Amel Sassi Kimberly Seaman Xin Song Chun-Yu Lin Yu Sun Lidan You Institute of Biomedical Engineering University of TorontoM5S 3G9Canada Department of Mechanical&Industrial Engineering University of TorontoM5S 3G9Canada Department of Mechanical and Materials Engineering Queen's UniversityK7L 3N6Canada

Prostate cancer(PCa)continues to rank among the most common malignancies in Europe and North America with significant mortality rates despite advancements in detection and *** activity is often recommended to PCa patients due to its benefits in preventing disease recurrence and managing treatment-related side ***,physical activity may be challenging for elderly or bedridden *** such,vibration therapy has been proposed as a safe,effective,and easy to perform alternative treatment that may confer similar effects as physical ***,low-magnitude high frequency(LMHF)vibration has been shown to decrease breast cancer extravasation into the bone and reduce other types of cancer proliferation by impacting cell ***,we investigated the effects of daily application of LMHF vibration(0.3 g,60 Hz,1 hour/day for 3 days)on prostate cancer growth and bone metastasis in *** findings suggest that LMHF vibration significantly reduces colony formation through a decrease in cell growth and ***,using a 3D cell culture model,LMHF vibration significantly reduces PC3 spheroid ***,LMHF vibration reduces PCa cell extravasation into the bone microenvironment through the stimulation of osteocytes and subsequent osteocyte-endothelial cell cross *** findings highlight the potential of LMHF vibration for managing PCa growth and metastasis.

关键词： low-magnitude high-frequency vibration Mechanical loading vibration Prostate cancer Bone metastasis Osteocyte Microfluidic Spheroid

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