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An ultra low-input method for global RNA structure probing uncovers Regnase-1-mediated regulation in macrophages

Fundamental Research 2022年第1期2卷 2-13页

作者： Meiling Piao Pan Li Xiaomin Zeng Xi-Wen Wang Lan Kang Jinsong Zhang Yifan Wei Shaojun Zhangas Lei Tang Jianghui Zhu Chun Kit Kwok Xiaoyu Hu Qiangfeng Cliff Zhang MOE Key Laboratory of Bioinformatics Center for Synthetic and Systems BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology&Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China Institute for Immunology and School of Medicine Tsinghua UniversityBeijingChina Beijing Key Laboratory for Immunological Research on Chronic Diseases Tsinghua-Peking Center for Life SciencesTsinghua UniversityBeijingChina department of Chemistry City University of Hong KongTat Chee AvenueKowloon TongHong KongChina Shenzhen Research Institute of City University of Hong Kong ShenzhenChina

To enable diverse functions and precise regulation,an RNA sequence often folds into complex yet distinct structures in different cellular *** RNA in its native environment is essential to uncovering RNA structures of biological ***,current methods generally require large amounts of input RNA and are challenging for physiologically relevant ***,we report smartSHAPE,a new RNA structure probing method that requires very low amounts of RNA input due to the largely reduced artefact of probing signals and increased efficiency of library *** smartSHAPE,we showcased the profiling of the RNA structure landscape of mouse intestinal macrophages upon inflammation,and provided evidence that RNA conformational changes regulate immune *** results demonstrate that smartSHAPE can greatly expand the scope of RNA structure-based investigations in practical biological systems,and also provide a research paradigm for the study of post-transcriptional regulation.

关键词： RNA structure probing method low-input RNA structure element Macrophage RNA structure RNA structurome

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Screening for Drought-Tolerant and low-input Responsive Upland Rice Landraces

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American Journal of Plant Sciences 2014年第22期5卷 3432-3439页

作者： Roberto B. Barba Jr. Nicca Aira A. Marquez Ruben P. Tablizo College of Agriculture and Fisheries Catanduanes State University Virac Catanduanes Philippines

Productivity potentials of upland rice landraces (URLs) are continuously compromised by scanty water supply due to competing priorities for irrigations and fluctuations in agro-ecological conditions peculiar to low-input farming systems. A growing demand for rice amidst decline in productive agricultural areas plunges into an urgent contribution of marginal areas critical in attaining food sufficiency among Filipino households. Agronomic performances of URLs locally found in Catanduanes province, Philippines were evaluated in a replicated trial utilizing three URLs: Kamanang [1], Kadari [2] and Bulaw [3]. The experimental set-up was closely monitored for consistent dry moisture content and zero fertilizer application. Results were significant for traditional upland landraces: Kamanang and Kadari, scored in terms of higher germination rate, increment plant height and the number of tillers during the vegetative stage. Leaf color gradations, although statistically not significant across cultivars, were suggestive of varying adaptive performance between traditional cultivars subjected to low-input system. Putative low-input responsive lines indicated by the higher survival percentage and overall agronomic responses were selected from the study site. Screened lines took part of the advance population which would be potentially able to tolerate poor soil conditions (i.e. poor storehouse of water and nutrients) especially in areas with edaphological constraints and changing rainfall distribution pattern. The development of putative drought tolerant lines among URLs forms the most economical solution implicated to areas with limited access to agricultural interventions.

关键词： Upland Rice Landraces low-input System Edaphological Constraints

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