检索结果-南通市图书馆

Risk factors for early progression of diffuse Low-grade glioma in adults

Chinese Neurosurgical Journal 2023年第1期9卷 9-17页

作者： Long Wang Xuegang Li Tunan Chen Chao Zhang Jiantao Shi Hua Feng Fei Li Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Background:To explore the risk factors for early progression of diffuse Low-grade glioma in adults.Methods:A retrospective analysis of pathologic and clinical data of patients diagnosed with diffuse Low-grade gliomas at Southwest Hospital between January 2010 and December 2014.The progression-free survival(PFS)less than 60 months was classified as the early progress group,and the PFS greater than 60 months was the control group for comparative analysis.Results:A total of 138 patients were included in this study,including 94 cases of astrocytoma and 44 cases of oligodendroglioma.There were 63 cases with 100%resection,56 cases with 90-100%resection degree,and 19 cases with resection degreelow-up time was 60 months,of which 80 patients progressed and 58 patients did not progress.The average progression-free survival was 61 months.The median progression-free survival was 60 months.There were 68 patients with PFS≤60 months and 70 patients with PFS>60 months.The two groups were compared for statistical analysis.In univariate analysis,there were significant differences in tumor subtype(p=0.005),range(p=0.011),volume(p=0.005),location(p=0.000),and extent of resection(p=0.000).Multifactor analysis shows tumor location(HR=4.549,95%CI:1.324-15.634,p=0.016)and tumor subtype(HR=3.347,95%CI=1.373-8.157,p=0.008),and imcomplete resection is factors influencing early progression of Low-grade glioma.Conclusions:Low-grade gliomas involving deep location such as basal ganglia,inner capsule,and corpus callosum are more likely to progress early,while incomplete resection is a risk factor in early progression of astrocytoma.

关键词： Risk factors Early progression Low-grade glioma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-dose radiation associated with improved survival in IDH-wildtype lowgrade glioma

引用

Chinese Neurosurgical Journal 2021年第2期7卷 126-130页

作者： Shuai Liu Yanwei Liu Guanzhang Li Jin Feng Li Chen Xiaoguang Qiu Department of Radiation Oncology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China

Background:As molecular advances have deepened the knowledge on Low-grade glioma(LGG),we investigated the effect of higher radiation dose on the survival of IDH-wildtype(IDHwt)LGG.Methods:In the current study,52 IDHwt LGG patients who received radiotherapy were enrolled from the Chinese glioma Genome Atlas dataset.Radiation doses>54 Gy were defined as high-dose,whereas doses≤54 Gy were defined as low-dose.We performed univariate and multivariate survival analyses to examine the prognostic role of high-dose radiotherapy.Results:In total,the radiation dose ranged from 48.6 Gy to 61.2 Gy,with a median of 55.8 Gy,and 31 patients were grouped into high-dose radiation.Univariate survival analysis indicated that high-dose radiotherapy(p=0.015),tumors located in the frontal lobe(p=0.009),and pathology of astrocytoma(p=0.037)were significantly prognostic factors for overall survival.In multivariate survival analysis,high-dose radiotherapy(p=0.028)and tumors located in the frontal lobe(p=0.016)were independently associated with better overall survival.Conclusions:In conclusion,high-dose radiotherapy independently improved the survival of IDHwt LGG.This can guide treatments for glioma with known molecular characteristics.

关键词： Radiation dose IDH-wildtype Low-grade glioma Survival

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasticity of language pathways in patients with Low-grade glioma A diffusion tensor imaging study

引用

Neural Regeneration Research 2013年第7期8卷 647-654页

作者： Gang Zheng Xiaolei Chen Bainan Xu Jiashu Zhang Xueming Lv Jinjiang Li Fangye Li Shen Hu Ting Zhang Ye Li Department of Neurosurgery Chinese PLA General Hospital Chinese PLA Postgraduate Medical School

Knowledge of the plasticity of language pathways neurosurgeons to achieve maximum resection wh n patients with Low-grade glioma is important for e preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with Low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with Low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively.

关键词： neural regeneration neuroimaging Low-grade glioma plasticity language pathways dlllUSlOntensor imaging fractional anisotropy lateralization index ventral language pathway dorsallanguage pathway glioma grants-supported paper photographs-containing paper neuroregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptability of language-related brain network in a Low-grade glioma patient

引用

Neural Regeneration Research 2011年第30期6卷 2372-2375页

作者： Olivera Sveljo Katarina Koprivsek Milos Lucic Diagnostic Imaging Centre Oncology Institute of VojvodinaSremska KamenicaSerbia

Because functional magnetic resonance imaging can be used for dynamic observation of functional cortical changes after brain injuries, we followed up functional magnetic resonance imaging manifestations of a language-related brain network in a Low-grade glioma patient. Disease progression and therapy during a 3-year period were followed up at different time points： before and after reoperation, after radiation therapy, and 1 year after irradiation. During the whole 3-year follow-up period, the patient exhibited no neurological deficits while functional magnetic resonance imaging revealed different topologies of the language-related brain network. During disease progression and after irradiation, the language-related brain network was extended or completely transferred to the nondominant （right） hemisphere. In addition, after reoperation and 1 year after irradiation, language areas were primarily found in the language dominant （left） hemisphere. Our results suggest a high level of adaptability of the language-related cortical network of the bilateral hemispheres in this Low-grade glioma patient.

关键词： functional magnetic resonance imaging Low-grade glioma cortical changes language-related brain network

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Post-operation life quality assessment depending on KPS in adult supratentorial superficial Low-grade glioma and relevant factors

Post-operation life quality assessment depending on KPS in a...

引用

2011中华医学会神经外科学学术会议

作者： Qing Mao1 Lu Ma1 Xiao-shu Dong1 1.Department of Neurosurgery, West China Hospital, Sichuan University

Objective We assessed the life quality of adult supratentorial superficial Low-grade glioma (ASS-LGG) patients depending on Karnofsky Performance Scale (KPS) and analyzed the relevant factors. Some benefit factors wer... 详细信息

关键词： Life quality Low-grade glioma Adult supratentorial superficial Surgical therapy Karnofsky Performance Scale （KPS） Impact factor

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Impact factor analysis of post-operation life quality according to KPS in adult supratentorial superficial Low-grade glioma

Impact factor analysis of post-operation life quality accord...

引用

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Lu Ma,Qing Mao Department of Neurosurgery,West China hospital,Sichuan University,Chengdu,Sichuan Province,P.R.China

Objective:We assessed the life quality of adult supratentorial superficial Low-grade glioma（ASS-LGG） patients according to Karnofsky Performance Scale（KPS） and analyzed the relevant factors.Some benefit factors were found through this research to guide the therapeutic strategy and improve the patients’ prognosis after glioma surgery.Method:One hundred and four adults with ASS-LGG were collected and analyzed retrospectively from 2008 to 2009.The follow-up time was from three months to half of a year.The logistic regression was used to discuss the relationship between the life quality after surgery according to KPS and the impact factors such as age,gender,operation time,size and location of the tumor,degree of resection,and tumor grade before surgery.Result:We found that four out of ten candidate factors have pertinence with the improvement of the life quality after surgery.They are age more than 40 years,the size of tumor less than 5cm,tumor located in the right hemisphere and limited resection of tumor in functional area.Conclusions:It’s seems more significant to judge ASS-LGG patients’ prognosis on the base of life quality because of the patients’ long-time survival.To ASS-LGG patients,we could predict the life quality according to KPS after surgery depending on the patients’ age,and size and location of the tumor.It is benefit to the improvement of life quality if the tumor is resected at early stage.Relieving the size of the tumor and acquiring the pathological diagnosis should be recommended instead of the en bloc resection in functional area.

关键词： life quality Low-grade glioma adult supratentorial superficial surgical therapy Karnofsky Performance Scale（KPS） impact factor

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

引用

Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for Low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on Low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a Low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management Low-grade glioma natural bioactives neural regeneration physical exercise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain Tumor Segmentation in Multimodal MRI Using U-Net Layered Structure

引用

Computers, Materials & Continua 2023年第3期74卷 5267-5281页

作者： Muhammad Javaid Iqbal Muhammad Waseem Iqbal Muhammad Anwar Muhammad Murad Khan Abd Jabar Nazimi Mohammad Nazir Ahmad Department of Information Technology The Superior UniversityLahorePakistan Department of Software Engineering The Superior UniversityLahorePakistan Department of Information Sciences Division of Science and TechnologyUniversity of EducationLahorePakistan Department of Computer Science Government College UniversityFaisalabadPakistan Deptment of Oral and Maxillofacial Surgery Faculty of DentistryUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia Institute of IR4.0 Universiti Kebangsaan MalaysiaBangiSelangorMalaysia

The brain tumour is the mass where some tissues become old or damaged,but they do not die or not leave their space.Mainly brain tumour masses occur due to malignant masses.These tissues must die so that new tissues are allowed to be born and take their place.Tumour segmentation is a complex and time-taking problem due to the tumour’s size,shape,and appearance variation.Manually finding such masses in the brain by analyzing Magnetic Resonance Images(MRI)is a crucial task for experts and radiologists.Radiologists could not work for large volume images simultaneously,and many errors occurred due to overwhelming image analysis.The main objective of this research study is the segmentation of tumors in brain MRI images with the help of digital image processing and deep learning approaches.This research study proposed an automatic model for tumor segmentation in MRI images.The proposed model has a few significant steps,which first apply the pre-processing method for the whole dataset to convert Neuroimaging Informatics Technology Initiative(NIFTI)volumes into the 3D NumPy array.In the second step,the proposed model adopts U-Net deep learning segmentation algorithm with an improved layered structure and sets the updated parameters.In the third step,the proposed model uses state-of-the-art Medical Image Computing and Computer-Assisted Intervention(MICCAI)BRATS 2018 dataset withMRI modalities such as T1,T1Gd,T2,and Fluidattenuated inversion recovery(FLAIR).Tumour types in MRI images are classified according to the tumour masses.Labelling of these masses carried by state-of-the-art approaches such that the first is enhancing tumour(label 4),edema(label 2),necrotic and non-enhancing tumour core(label 1),and the remaining region is label 0 such that edema(whole tumour),necrosis and active.The proposed model is evaluated and gets the Dice Coefficient(DSC)value for High-grade glioma(HGG)volumes for their test set-a,test set-b,and test set-c 0.9795, 0.9855 and 0.9793, respectively. DSC value for the low-gradeglioma (LGG) volumes

关键词： Brain tumour segmentation magnetic resonance images modalities dice coefficient Low-grade glioma U-Net

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Concise review of radiosurgery for contemporary management of pilocytic astrocytomas in children and adults

引用

World Journal of Experimental Medicine 2022年第3期12卷 36-43页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal Hakan Gamsiz Esra Gumustepe Fatih Ozcan Onurhan Colak Ahmet Tarik Gursoy Cemal Ugur Dursun Ahmet Oguz Tugcu Galip Dogukan Dogru Rukiyye Arslan Yelda Elcim Esin Gundem Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesAnkara 0090Turkey

Pilocytic astrocytoma(PA)may be seen in both adults and children as a distinct histologic and biologic subset of Low-grade glioma.Surgery is the principal treatment for the management of PAs;however,selected patients may benefit from irradiation particularly in the setting of inoperability,incomplete resection,or recurrent disease.While conventionally fractionated radiation therapy has been traditionally utilized for radiotherapeutic management,stereotactic irradiation strategies have been introduced more recently to improve the toxicity profile of radiation delivery without compromising tumor control.PAs may be suitable for radiosurgical management due to their typical appearance as well circumscribed lesions.Focused and precise targeting of these well-defined lesions under stereotactic immobilization and image guidance may offer great potential for achieving an improved therapeutic ratio by virtue of radiosurgical techniques.Given the high conformality along with steep dose gradients around the target volume allowing for reduced normal tissue exposure,radiosurgery may be considered a viable modality of radiotherapeutic management.Another advantage of radiosurgery may be the completion of therapy in a usually shorter overall treatment time,which may be particularly well suited for children with requirement of anesthesia during irradiation.Several studies have addressed the utility of radiosurgery particularly as an adjuvant or salvage treatment modality for PA.Nevertheless,despite the growing body of evidence supporting the use of radiosurgery,there is need for a high level of evidence to dictate treatment decisions and establish its optimal role in the management of PA.Herein,we provide a concise review of radiosurgery for PA in light of the literature.

关键词： Pilocytic astrocytoma Radiosurgery Stereotactic irradiation Low-grade glioma Radiation oncology Children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Resting-state functional connectivity predicts individual language impairment of patients with left hemispheric gliomas involving language network

Resting-state functional connectivity predicts individual la...

引用

第二十二届全国心理学学术会议

作者： Binke Yuan Nan Zhang Jing Yan Junfeng Lu Jinsong Wu Center for Language and Brain Shenzhen Institute of Neuroscience Department of Neurosurgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan University Department of MRI The First Affiliated Hospital of Zhengzhou University Shanghai Key Laboratory of Medical Image Computing and Computer Assisted Intervention

Aim: Language deficits following brain tumors should consider the dynamic interactions between different tumor growth kinetics and functional network reorganization. However, no study has attempted to investigate the language network basis at the whole brain level to determine the language network reorganization differences between Low-grade glioma(LGG) and high-grade glioma(HGG) patients. Methods: Inclusion Criteria:(1) Pathologically confirmed glioma in left cerebral hemisphere and overlapped or was within the language network areas proposed by Fedorenko et al.(2010);(2) patients’ age was 18–75 years old;(3) Right-handedness;(4) No symptoms of motor impairment;(5) No history of brain surgery;(6) No midline shift in structural images;(7) No history of other major neurological or psychiatric disorders. In total, 126 patients,including 77 patients with LGG and 49 patients with HGG met all inclusion criteria and completed the entire preoperative clinical, language, and imaging data acquisition. All processes strictly followed the requirements of the Declaration of Helsinki. This study was approved and supervised by the Ethics Committee of Huashan Hospital and the Ethics Committee of the First Affiliated Hospital of Zhengzhou University, respectively. Written informed consents were obtained from the human subjects and their legal guardians. Language function: ABC(Aphasia Battery for Chinese speakers) was used and Aphasia Quotient(AQ) score(range, 0–100) was calculated for each patient. Rs-f MRI data: TR = 2,000 ms;TE = 35 ms;FA =90°;240 volumes;eyes closed. T1 and T2 images were also acquired for tumor mapping and registration. Rs-f MRI data preprocessing: slice timing, motion correction, normalization by DARTEL(MNI), smoothness(6 mm), detrend, nuisance regression, filter(0.01-0.1 Hz) and scrubbing(FD > 0.05). No patients exhibited a head motion > 3 mm maximum translation or 3° rotation. Nuisance signals included 36 head motion parameters, global signals, cerebrospinal fluid signals and white matter signals. Network

关键词： Low-grade glioma high-grade glioma resting-state fMRI language machine learning

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：