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Regulated extravascular microenvironment via reversible thermosensitive hydrogel for inhibiting calcium influx and vasospasm

引用

Bioactive Materials 2023年第3期21卷 422-435页

作者： Binfan Zhao Yaping Zhuang Zhimo Liu Jiayi Mao Shutong Qian Qiuyu Zhao Bolun Lu Xiyuan Mao Liucheng Zhang Yuguang Zhang Wenguo Cui Xiaoming Sun Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s Hospital Shanghai JiaoTong University School of Medicine 639 Zhi Zao Ju RoadShanghai200011PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China

Arterial vasospasm after microsurgery can cause severe obstruction of blood flow manifested as low tissue temperature,leading to tissue *** timely discovery and synchronized treatment become *** this study,a reversible,intelligent,responsive thermosensitive hydrogel system is constructed employing both the gel–sol transition and the sol–gel ***“reversible thermosensitive(RTS)”hydrogel loaded with verapamil hydrochloride is designed to dynamically and continuously regulate the extravascular microenvi-ronment by inhibiting extracellular calcium *** accurate implantation and following in situ gelation,the RTS hydrogel reverses to the sol state causing massive drug release to inhibit vasospasm when the tissue tem-perature drops to the predetermined transition *** restoration of the blood supply allevi-ates further tissue *** the temperature drops,the RTS hydrogel maintains the gel state as a sustained-release reservoir to prevent *** inhibition of calcium influx and vasospasm in vitro and in vivo is demonstrated using vascular smooth muscle cells,mice mesenteric arterial rings,and vascular ultrasonic Doppler *** animal experiments demonstrate that RTS hydrogel can promote tissue survival and alleviate tissue injury responding to temperature ***,this RTS hydrogel holds therapeutic po-tential for diseases requiring timely detection of temperature change.

关键词： Reversible thermosensitive hydrogel low temperature response Calcium influx Vasospasm Vascular

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