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low ca diet leads to increased ca retention by changing the gut flora and ileal pH value in laying hens

Animal Nutrition 2023年第2期13卷 270-281页

作者： Sha Jiang Xinyu Zou Miao Mao Mi Zhang Wenjun Tu Meilan Jin Joint International Research Laboratory of Animal Health and Animal Food Safety College of Veterinary MedicineSouthwest UniversityChongqing400715China Immunology Research Center Medical Research InstituteSouthwest UniversityChongqing402460China Laboratory Animal Center Southwest UniversityChongqing400715China

Osteoporosis is a common degenerative metabolic bone disease in caged laying hens.Intensive egg production mobilizing large amounts of ca from bone for eggshell formation,consequently leading to ca deficiency,has been recognized as a critical factor causing osteoporosis in commercial laying hens.The aim of this study was to examine the effect of ca deficiency on the function of the gut microbiotaebone axis and related egg production traits and bone health in laying hens.Twenty-four 48-week-old laying hens were fed a control diet(Control,3.72%)or a low ca diet(LC,2.04%)for 60 d(n=12).Compared to the Control hens,the LC hens had higher levels of alkaline phosphatase and tartrate resistant acid phosphatase(Plower bone strength,eggshell thickness,and eggshell strength(Plower concentrations of interleukin-1(IL-1)and IL-6.The LC hens also had a lower pH value in the ileum with an increased ca retention.The principal co-ordinates analysis showed significantly separate cecal microbiota populations between the Control and LC hens.The Prevotellaceae_UCG-001,Subdoligranulum,Peptococcus,and Eubacterium_hallii_group(Plower at the genus level in the LC hens.In addition,Prevotellaceae_UCG-001,Subdoligranulum and Eubacter-ium_hallii_group had a negative correlation,while Sutterella was positively correlated with ileal pH values.The transcriptome analysis revealed that the low ca diet caused 20 and 31 genes to be signifi-cantly up-and down-regulated,respectively.The gene expressions of cystic fibrosis transmembrane conductance regulator,solute carrier family 26 member 3 of the anion exchangers,and mitogen-activated protein kinase 12 of pro-inflammatory factors were lower in the LC birds,which was corre-lated with the lower ileal pH values.These results suggest that the hens with low ca diet-induced osteoporosis have an increased intestinal ca retention with a decreased i

关键词： low ca diet ca retention Microbiota Transcriptional profiling Hen

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