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Low levels of low-density lipoprotein cholesterol and cognitive decline

Science Bulletin 2021年第16期66卷 1684-1690,M0004页

作者： Rong Hua Yanjun Ma Chenglong Li Baoliang Zhong Wuxiang Xie Heart and Vascular Health Research Center Peking University Clinical Research InstitutePeking University First HospitalBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences(Peking University) Ministry of EducationBeijing 100191China Department of Geriatric Psychiatry Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430030China

The relationship between low levels of serum low-density lipoprotein cholesterol(LDL-C)and subsequent cognitive decline remains *** present study aimed to evaluate the longitudinal association between low LDL-C levels and cognition decline in the context of the current aggressive guideline-recommended targets(LDL-C levels less than 55 mg/dL for individuals at very high risk of cardiovascular events,and less than 70 mg/dL for high risk individuals).Data from wave 13(2016)to wave 14(2018)of the Health and Retirement study(HRS)were ***-C concentrations measured at wave 13 were categorized into 5 levels,reflecting currently recommended values for lipid lowering *** 7129 included participants(mean age:69.0±9.9 years,60.3%female),we found that compared to participants with LDL-C levels of 70.0-99.9 mg/dL,those with LDL-C levels ofstudy demonstrated that compared with LDL-C levels 70.0-99.9 mg/dL,low LDL-C levels(<70 mg/dL,especially<55 mg/dL)were associated with significantly slower cognitive decline in population-based *** randomized controlled trials are warranted to ascertain the safety and benefit of current aggressive guideline-recommended targets on cognitive function.

关键词： Low-density lipoprotein cholesterol Cognitive decline longitudinal cohort study The Health and Retirement study

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