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long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin

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World Journal of Gastroenterology 2011年第4期17卷 493-498页

作者： María Trapero-Marugán Jorge Mendoza María Chaparro Leticia González-Moreno José Andrés Moreno-Monteagudo María Jesús Borque Ricardo Moreno-Otero Gastroenterology-Hepatology Department University Hospital La Princesa and Princesa Research Institute Autonomous University of Madrid and CIBERehd (Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas)

AIM: To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFN) plus ribavirin combination therapy. METHODS: One hundred and fifty three patients with a SVR after treatment with PEG-IFN plus ribavirin were included in a 5-year follow-up study in a single Spanish center, based on standard clinical practice. Clinical anamnesis, biochemical analysis, hepatitis C virus RNA and alpha-fetoprotein measurement, ultrasonography and transient elastography were performed annually. RESULTS: The mean follow-up period of the 153 patients was 76 ± 13 mo after they obtained a SVR. Five patients (3.26%) presented with cirrhosis before treatment and 116 (75.8%) had genotype 1. No patient showed evidence of hepatic decompensation. One patient (0.65%) developed a hepatocellular carcinoma at month 30 after achieving SVR. There were no virological relapses during this follow-up period. Persistently elevated alanine aminotransferase was found in only one patient (0.65%). At the end of the 5-year follow-up, the mean value of transient elastography was 7 ± 4.3 kPa (F1). There were no deaths and no other tumors. CONCLUSION: The long-term outcome of 153 CHC patients with SVR to PEG-IFN plus ribavirin was good. No evidence of a virological relapse was seen. One patient (0.65%) developed a hepatocellular carcinoma.

关键词： Chronic hepatitis C Peginterferon Ribavirin Sustained virological response long-term effects

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Self-perceptions and social–emotional classroom engagement following structured physical activity among preschoolers: A feasibility study

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Journal of Sport and Health Science 2017年第2期6卷 241-247页

作者： Spyridoula Vazou Constantine Mantis Gayle Luze Jacqueline S.Krogh Department of Kinesiology Iowa State UniversityAmesIA 50011USA Department of Human Development and Family Studies Iowa State UniversityAmesIA 50011USA

Background: The well-rounded development of the child, including physical, cognitive, emotional, and social health, may be the most efficient route to well-being and academic success. The primary goal was to investigate the feasibility of implementing a 12-week structured program of physical activity(PA) incorporating cognitive, social, and emotional elements in preschool. Additionally, this study, using a within-subject design,examined the acute effects of a PA session on classroom engagement and changes on perceived competence and peer acceptance from the first to the last week of the ***: Twenty-seven preschoolers(mean age = 4.2 years) completed the Pictorial Scale of Perceived Competence and Social Acceptance for Young Children before and after a twice-weekly PA program. Unobtrusive classroom observations were conducted for verbal, social, and affective engagement during the first and last week of the program, both following a structured PA session(experimental day) and on a day without PA(control day). Treatment fidelity was monitored to ensure that the intervention was delivered as ***: The children exhibited longer periods of verbal and social engagement during classroom periods that followed PA sessions than on non-PA days. Children also expressed more positive affect following PA sessions during the last week of the PA program. Despite high baseline scores,perceptions of general competence increased meaningfully(η2= 0.15, p = 0.05), driven by increase in perceptions of cognitive competence(η2= 0.15,p = 0.06).Conclusion: This study demonstrates the feasibility of providing structured PA program to preschoolers. Moreover, these initial findings suggest that purposely designed, structured PA may help advance the social–emotional engagement and perceived competence of preschool children.

关键词： Acute Intervention long-term effects Movement Peer acceptance Perceived competence

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Perihepatic adhesions: An unusual complication of hemolysis, elevated liver enzymes and low platelet syndrome

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World Journal of Gastroenterology 2014年第26期20卷 8726-8728页

作者： Margot M Koeneman Ger H Koek Marc Bemelmans Louis L Peeters Department of Obstetrics and Gynecology Maastricht University Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineMaastricht University Medical Center Department of Surgery Maastricht University Medical Center

We present a case of symptomatic perihepatic adhesions,which developed after a pregnancy complicated by hemolysis,elevated liver enzymes and low platelet(HELLP)syndrome,in which a subcapsular liver hematoma *** patient presented with complaints of persistent,severe right-sided upper abdominal *** complaints developed gradually,one year after a pregnancy that had been complicated by HELLP syndrome with a subcapsular liver *** hematoma had resolved *** upperabdominal magnetic resonance imaging revealed a density between liver and diaphragm at the site of the former subcapsular hematoma,suspect of perihepatic *** presence of perihepatic adhesions was confirmed during a laparoscopy and treated by adhesiolysis in the same *** adhesions may have developed in response to the degradation process of the subcapsular liver hematoma during conservative *** case of perihepatic adhesions may therefor be the first presentation of a long term sequel of subcapsular liver hematoma in HELLP syndrome.

关键词： Hemolysis elevated liver enzymes and low platelet syndrome Liver Haematoma long-term effects Adhesions Tissue

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long-term feeding of sand rice(Agriophyllum squarrosum seed)can improve the antioxidant capacity of mice

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Research in Cold and Arid Regions 2023年第2期15卷 105-112页

作者： PengShu Zhao Liang Shi Xia Yan ChaoJu Qian WeiJia Zhao Yan Chang XiaoYue Yin XingKe Fan TingZhou Fang YuQiu Liao ShanShan Zhou XiaoFei Ma Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environments and ResourcesChinese Academy of SciencesLanzhouGansu730000China Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions of Gansu Province Northwest Institute of Eco-Environments and ResourcesChinese Academy of SciencesLanzhouGansu730000China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Inland River Ecohydrology Cold and Arid Regions Environmental and Engineering ResearchNorthwest Institute of Eco-Environments and ResourcesChinese Academy of SciencesLanzhouGansu730000China School of Life Sciences Nantong UniversityNantongJiangsu226019China Institute of Qinghai-Tibetan Plateau Research Southwest Minzu UniversityChengduSichuan610041China Shanxi Institute of Science and Technology Faculty of Environmental Science and EngineeringJinchengShanxi048000China

Unhealthy eating habits with sugar-rich and high-fat foods can bring nutritional imbalance and other chronic diseases. At present, there is an increasing demand in regulating human sub-health through functional foods. Agriophyllum squarrosum(L.) Moq., a pioneer plant native to sand dunes with ecological restoration function, is a traditional food plant of sand regions and Mongolian folk medicine. Numerous studies have confirmed that A. squarrosum seed, also called sand rice, has high nutritional value. However, the long-term health effects of eating sand rice remain unclear. To better explore and evaluate its long-term effects, hereby, ICR mice were fed with sand rice flour at different ratios(control, 60% and 95%) for 100 days. Results show that the growth and blood glucose level curve of these experimental mice were lower and more stable than that of the control. In addition, mice fed pure sand rice ingredient(95%) gained more stable body weight and blood glucose after 28 days, which revealed that sand rice is a food with comprehensive nutritional value and rarely negatively impacts the body growth performance. Our data also demonstrates that, the content of triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) provided the lowest level in the blood of mice with a diet of pure sand rice ingredient, 0.48, 4.14, 0.91, 3.03 mmol/L, respectively. Also, T-SOD and GSH-PX activity provided a high level in mice with pure sand rice gradient, which significantly increased by 36%(T-SOD)and 19%(GSH-PX) compared to the control. These results suggest that long term intake of the pure sand rice ingredients is more helpful for stabilizing blood lipid and improve antioxidant capacity and beneficial to people suffering from chronic disease. This study supplies the first animal evidence to support the claim that sand rice is a promising functional food with comprehensive nutrition in the future. We are con

关键词： Sand rice Functional food long-term effects Health evaluation Antioxidant capacity

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Initial Labor Market Conditions and Individual Employability

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China Economist 2023年第3期18卷 44-67页

作者： Luo Chuliang Gao Tianyi Zou Xianqiang School of Labor and Human Resources Renmin University of ChinaBeijingChina

Initial labor market conditions affect how individuals build their human capital and look for jobs and thus can have long-term effects on their income levels,work performance,and career *** on data from the Urban Household Survey(UHS)of urban households in China from 1986 to 2009,we perform an empirical test of how initial labor market conditions affect the employability of *** research shows that people’s future incomes suffer if they start out in an adverse job *** percentage point of increase in the unemployment rate at an individual’s entry into the labor market is associated with a two-percentage-point drop in his or her average annual *** after looking at different parts of the job market and sample groups,this conclusion still *** the context of global economic instability,our findings may assist government policymakers in addressing adverse labor market conditions.

关键词： Initial labor market conditions unemployment labor market frictions short-term effects long-term effects

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Subthalamic nucleus deep brain stimulation for Parkinson’s disease: 8 years of follow-up

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Translational Neurodegeneration 2013年第1期2卷 68-71页

作者： Dianyou Li Chunyan Cao Jing Zhang Shikun Zhan Shengdi Chen Bomin Sun Department of Functional Neurosurgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of Neurology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

Objective:The short-term benefits of bilateral stimulation of the subthalamic nucleus(STN)in patients with advanced Parkinson’s disease(PD)are well documented,but long-term benefits are still *** aim of this study is to evaluate the outcome of 8 years of bilateral STN stimulation to PD ***:In this study,31 consecutive PD patients were treated with bilateral STN *** functional status was measured using the Activities of Daily Living section of the Unified Parkinson’s Disease Rating Scale(UPDRS-ADL)at drug on(with medication)and drug off(without medication)states preoperatively and at 1,5,and 8 years *** addition,Levodopa equivalent doses and stimulation parameters were also ***:After 8 years of STN stimulation,the UPDRS-ADL scores were improved by 4%at drug off status(P>0.05)and 22%at drug on status(P<0.05)compared with baseline;the levodopa daily doses were reduced by 28%(P<0.05)compared with baseline;the stimulation voltage and pulse width were not changed,but the stimulation frequency was decreased remarkably compared with the 5 years of *** events were observed in 6 patients,including misplacement of the electrode and skin erosion requiring further *** events were resolved without permanent sequelae.2 patients died of aspiration pneumonia 6 and 7 years after ***:The marked improvement in UPDRS-ADL scores were still observed after 8 years of bilateral STN stimulation with medication.

关键词： Deep brain stimulation long-term effects Parkinson’s disease Subthalamic nucleus

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Neuropsychological Assessment of Learning and Memory in Rats Following Ketamine Exposure during Late Adolescence

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Journal of Behavioral and Brain Science 2020年第12期10卷 568-589页

作者： Julianna M. Davis David Compton Miranda Heit Ashley Fravel Kimberly Wood Department of Psychology Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach USA

With the prevalent issue of drug abuse in society, research regarding the effects of ketamine, a drug frequently abused by youth in club settings, has increased. Despite its potential for misuse, ketamine has demonstrated potential as a fast-acting antidepressant and seems to work well for relieving treatment-resistant depression. However, previous research has shown ketamine use may cause impairments in frontal and medial temporal lobe functioning, leading to problems with memory. While under the influence of ketamine, individuals also display problems with spatial working memory when compared to individuals not dosed with ketamine. The majority of previous research has examined the short-term impact of ketamine use with studies on neurodevelopment largely confined to postnatal exposure. In the present study, the long-term effects on memory caused by repeated ketamine exposure during late adolescence were examined. Rats were used as nonhuman models in order to investigate the cognitive risks resulting from chronic use of ketamine. The results indicated that low-ketamine dosed rats demonstrated significantly better spatial memory recall compared to high-ketamine dosed rats. In addition, high-ketamine dosed rats appeared to struggle more with working memory than the rats in the low-ketamine and control groups. Similarly, both drug groups showed significantly more working memory and reference memory errors than the control group. This indicates that higher doses of ketamine during late adolescence may cause working and spatial memory impairments later in life.

关键词： Ketamine Memory Impairments long-term effects Spatial Memory Working Memory

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