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Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents

Bioactive Materials 2022年第3期7卷 157-167页

作者： Hao Huang Guotao Yuan Ying Xu Yuan Gao Qiulian Mao Yin Zhang Lu Bai Weijie Li Anqing Wu Wentao Hu Yue Pan Guangming Zhou State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou510120PR China Department of Nutrition and Food Hygiene Soochow University of Public HealthSuzhou215123China

The integration of photothermal therapy(PTT)with gene therapy(GT)in a single nanoscale platform demonstrates great potential in cancer *** iron oxide nanoagents(PIONs)are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal ***,the therapeutic efficacy of PIONs-mediated GT has not been *** long noncoding rna(lncrna)crybg3(LNC crybg3),a lncrna induced by heavy ion irradiation in lung cancer cells,has been reported to directly bind to globular actin(G-actin)and cause degradation of cytoskeleton and blocking of cytokinesis,thus indicating its potential for use in GT by simulating the effect of heavy ion irradiation and functioning as an antitumor *** the present study,we investigated the possibility of combining PIONs-mediated PTT and LNC crybg3-mediated GT to destroy non-small cell lung cancer(NSCLC)cells both in vitro and in *** combination therapy showed a high cancer cell killing efficacy,and the cure rate was better than that achieved using PTT or GT ***,as a type of magnetic nanoagent,PIONs can be used for magnetic resonance imaging(MRI)and photoacoustic imaging(PAI)both in vitro and in *** findings indicate that the new combination therapy has high potential for cancer treatment.

关键词： Gene therapy(GT) Porous iron oxide nanoagents(PIONs) Photothermal therapy(PTT) long noncoding rna crybg3

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