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Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana(A. Rich.) Engl.(Burseraceae) and loeseneriella africana(Willd.)(Celastraceae) stem leaves extracts

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 665-670页

作者： Moussa Compaore Roland Nag-Tiero Meda Sahabi Bakasso Laurian Vlase Martin Kiendrebeogo Laboratory of Applied Biochemistry and Chemistry University of Ouagadougou Laboratory for Research and Education in Animal Health and Biotechnology Polytechnic University of Bobo-Dioulasso Chemistry Laboratory Department of Chemistry Faculty of Science and Technology Abdou Moumouni University of Niamey Department of Pharmaceutical Technology and Biofarmceutics University of Medicine and Pharmacy 《Iuliu Hatieganu》Faculty of Pharmacy Culture Platform of Cell and Tissue (PCCT) U.F.R/S.V.T. University of Ouagadougou

Objective: To assess the antioxidant and anti-inflammatory activities as well as to determine the flavonoids and phenolic acids content of active ***: Two medicinal plant samples were extracted successively in Soxhlet apparatus with n-hexane, dichloromethane, acetonitrile, ethyl acetate, methanol and n-butanol. Five methods were used to evaluate the antioxidant activity. Anti-inflammatory activity was done through the inhibition of the cyclooxygenase enzymes(COX-1 and COX-2).Polyphenolic compounds were analyzed by using a spectrophotometrical and high performance liquid chromatography-mass spectrometry(HPLC-MS) ***: The data showed that the stem leaves extracts of Commiphora africana and loeseneriella africana possessed significant in vitro antioxidant and anti-inflammatory activities. Polar extracts had radical scavenging effects and they reduced iron(III). The prostaglandin production was significantly stopped by acetonitrile and methanol *** biological activities were supported by some bioactive compounds quantified by using the HPLC-MS. p-Coumaric acid, ferulic acid, isoquercitrin, quercitrin, quercetin,rutin, kaempferol and apigenin were the most metabolites ***: The present study may explain the effectiveness of plants in traditional medicine of Burkina Faso, singularly Commiphora africana and loeseneriella *** next investigation was to sub-fractionate the methanol fraction in order to isolate new antioxidant and/or anti-inflammatory compounds.

关键词： Commiphora africana loeseneriella africana Antioxidant Anti-inflammation Phenolics HPLC-MS

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