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Estrogen receptor （α and β） but not androgen receptor expression is correlated with recurrence, progression and survival in post prostatectomy T3NOMO locally advanced prostate cancer in an urban Greek population

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Asian Journal of Andrology 2015年第1期17卷 98-105,I0009,I0010页

作者： Georgios Megas Michael Chrisofos Ioannis Anastasiou Aida Tsitlidou Theodosia Choreftaki Charalampos Deliveliotis Department of Urology General Hospital of Athens "G. Gennimatas" Greece Department of Urology Athens Medical School "Attiko" Hospital Athens Greece Department of Urology Athens Medical School "Laiko" Hospital Athens Greece Department of Pathology General Hospital of Athens "G. Gennimatas" Greece Department of Urology Athens Medical School "Sismanoglio" Hospital Athens Greece.

The objective of this study was to evaluate the expression of estrogen receptors （ER（（α ） and ER（β）） and androgen receptors （ARs） as prognostic factors for biochemical recurrence, disease progression and survival in patients with pT3NOMO prostate cancer （PCa） in an urban Greek population. A total of 100 consecutive patients with pT3NOMO PCa treated with radical prostatectomy participated in the study. The mean age and follow-up were 64.2 and 6 years, respectively. The HSCORE was used for semi-quantitative analysis of the immunoreactivity of the receptors. The prognostic value of the ER（（α） and ER（β） and AR was assessed in terms of recurrence, progression, and survival. AR expression was not associated with any of the above parameters; however, both ERs correlated with the prognosis. A univariate Cox regression analysis showed that ER（α） positive staining was significantly associated with a greater hazard for all outcomes. Increased ER（β） staining was significantly associated with a lower hazard for all outcomes in the univariate analysis. When both ER HSCORES were used for the analysis, it was found that patients with high ER（α） or low ER（β） HSCORES compared with patients with negatively stained ER（α） and 〉1.7 hSCORE ER（β） had 6.03, 10.93, and 10.53 times greater hazard for biochemical disease recurrence, progression of disease and death, respectively. Multiple Cox proportional hazard analyses showed that the age, preoperative prostate specific antigen, Gleason score and ERs were independent predictors of all outcomes. ER expression is an important prognosticator after radical prostatectomy in patients with pT3NOMO PCa. By contrast, AR expression has limited prognostic value.

关键词： androgen receptor estrogen receptor (α) estrogen receptor (β) locally advanced prostate cancer radical prostatectomy

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Perioperative complications of radical retropubic prostatectomy in patients with locally advanced prostate cancer： a comparison with clinically localized prostate cancer

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Asian Journal of Andrology 2013年第2期15卷 241-245,I0007,I0008页

作者： Xu-Dong Yao Xiao-Jun Liu Shi-Lin Zhang Bo Dai Hai-Liang Zhang Ding-Wei Ye Department of Urology Cancer Hospital Fudan University Shanghai 200032 China Shanghai Medical College Fudan University Shanghai 200032 China

Radical prostatectomy （RP） continues to be an effective surgical therapy for prostate carcinoma, particularly for organ-confined prostate cancer （PCa）. Recently, RP has also been used in the treatment of locally advanced prostate cancer. However, little research has been performed to elucidate the perioperative complications associated with RP in patients with clinically localized or locally advanced PCa. We sought to analyse the incidence of complications in these two groups after radical retropubic prostatectomy （RRP）. From June 2002 to July 2010, we reviewed 379 PCa patients who underwent RRP in our hospital. Among these cases, 196 had clinically localized PCa （Tla-T2c group 1）, and 183 had locally advanced PCa （ ≥ T3,： group 2）. The overall complication incidence was 21.9%, which was lower than other studies have reported. Perioperative complications in patients with locally advanced PCa mirror those in patients with clinically localized PCa （26.2% vs. 17.8%, P=0.91）. Our results showed that perioperative complications could not be regarded as a factor to consider in regarding RP in patients with cT3 or greater.

关键词： complications clinically localized prostate cancer locally advanced prostate cancer prostate cancer (PCa) prostatectomy radical retropubic prostatectomy (RRP)

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The role of radiotherapy in localised and locally advanced prostate cancer

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Asian Journal of Urology 2019年第2期6卷 153-161页

作者： Michel Bolla Ann Henry Malcom Mason Thomas Wiegel Department of Radiation Oncology Grenoble Alpes UniversityGrenobleFrance Department of Clinical Oncology St.James’s University HospitalLeedsUK Cardiff University Velindre HospitalWhitchurchUK Department of Radiation Oncology University Hospital UlmGermany

For a patient suffering from non-metastatic prostate cancer,the individualized recommendation of radiotherapy has to be the fruit of a multidisciplinary approach in the context of a Tumor Board,to be explained carefully to the patient to obtain his informed *** beam radiotherapy is now delivered by intensity modulated radiotherapy,considered as the gold *** a radiotherapy perspective,low-risk localized prostate cancer is treated by image guided intensity modulated radiotherapy,or brachytherapy if patients meet the required eligibility ***-risk patients may benefit from intensity modulated radiotherapy combined with 4e6 months of androgen deprivation therapy;intensity modulated radiotherapy alone or combined with brachytherapy can be offered to patients unsuitable for androgen deprivation therapy due to co-morbidities or unwilling to accept it to preserve their sexual ***-risk prostate cancer,***-risk localized and locally advanced prostate cancer,requires intensity modulated radiotherapy with long-term(≥2 years)androgen deprivation therapy with luteinizing hormone releasing hormone ***-operative irradiation,either immediate or early deferred,is proposed to patients classified as pT3pN0,based on surgical margins,prostate-specific antigen values and quality of *** the techniques and their degree of sophistication,quality assurance plays a major role in the management of radiotherapy,requiring the involvement of physicians,physicists,dosimetrists,radiation technologists and computer *** patients must be informed about the potential morbidity of radiotherapy and androgen deprivation therapy and followed regularly during and after treatment for tertiary prevention and evaluation.A close cooperation is needed with general practitioners and specialists to prevent and mitigate side effects and maintain quality of life.

关键词： Localized prostate cancer locally advanced prostate cancer Brachytherapy Intensity modulated radiotherapy Short-term and longterm androgen deprivation therapy

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Outcomes of locally advanced prostate cancer:a single institution study of 209 patients in Japan

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Asian Journal of Andrology 2006年第5期8卷 555-561页

作者： ToshihiroSaito YasuoKitamura ShuichiKomatsubara YasuoMatsumoto TadashiSugita Noboru Hara Department of Urology Niigata cancer Center Hospital Niigata 951-8566Japan Radiotherapy Niigata Cancer Center HospitalNiigata 951-8566Japan Department of Urology Niigata cancer Center Hospital Niigata 951-8566Japan Division of Urology Department of Regenerative and Transplant MedicineGraduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan

Aim： To investigate the outcomes for Asian populations with locally advanced/clinical stage Ⅲ prostate cancer （PCa） treated with currently prevailing modalities. Methods： We reviewed the record of 209 patients with clinical stage Ⅲ PCa, who were treated at Niigata cancer Center Hospital between 1992 and 2003. Treatment options included hormone therapy-combined radical prostatectomy （RP＋HT）, hormone therapy-combined external beam irradiation （EBRT＋HT） and primary hormone therapy （PHT）. Results： The 5- and 10-year overall survival rates were 80.3% and 46.1% in all cohorts, respectively. The survival rates were 87.3% and 66.5% in the RP＋HT group, 94.9% and 70.0% in the EBRT＋HT group and 66.1% and 17.2% in the PHT group, respectively. A significant survival advantage was found in the EBRT＋HT group compared with that in the PHT group （P 〈 0.0001）. Also, the RP＋HT group had better survival than the PHT group （P = 0.0107）. The 5- and 10-year disease-specific survival rates for all cases were 92.5% and 80.0%, respectively. They were 93.8% and 71.4% in the RP＋HT group, 96.6% and 93.6% in the EBRT＋HT group and 88.6% and 62.3% in the PHT group, respectively. A survival advantage was found in the EBRT＋HT group compared with the PHT group （P = 0.029）. No significant difference was found in disease-specific survival between the EBRT＋HT and RP＋HT groups or between the RP＋HT and PHT groups. Condusion： Although our findings indicate that radiotherapy plus HT has a survival advantage in this stage of PCa, we recommend therapies that take into account the patients＇ social and medical conditions for Asian men with clinical stage Ⅲ PCa.

关键词： locally advanced prostate cancer radical prostatectomy radiotherapy hormone therapy

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