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local hyperthermia combined with chemotherapy for the treatment of multiple recurrences of undifferentiated pleomorphic sarcoma:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2916-2922页

作者： Yi-Ting Zhou Ruo-Yu Wang Yao Zhang Dong-Yi Li Jian Yu hyperthermia Center The Affiliated Zhongshan Hospital of Dalian UniversityDalian 110006China Department of Medical Oncology The Affiliated Zhongshan Hospital of Dalian UniversityDalian 110006China Department of Bone and Soft Tissue Oncology The Affiliated Zhongshan Hospital of Dalian UniversityDalian 110006China

BACKGROUND Undifferentiated pleomorphic sarcoma(UPS)is a type of soft tissue sarcoma,the histologic origin and differentiation direction of which are still *** are few treatment options for UPS other than *** we describe a patient who had multiple recurrences of UPS postoperatively,but R0 resection was achieved by local hyperthermia combined with chemotherapy,thus providing a new treatment approach for similar *** SUMMARY A 65-year-old man sought evaluation from a physician for a mass on his right *** surgery,the pathologic diagnosis was *** the follow-up evaluations until 2021,the patient had four relapses of varying *** pathology confirmed the recurrence of UPS on the right *** March 2021,he underwent local hyperthermia combined with two cycles of chemotherapy for recurring *** magnetic resonance imaging reexamination and preoperative examination,the patient chose surgery *** the operation,the tumors were easy to excise,the amount of bleeding decreased significantly,and the pathologic evaluation confirmed that one of the specimens was an R0 *** local hyperthermia combined with chemotherapy enables R0 resection to be achieved in patients with advanced UPS recurrence.

关键词： Undifferentiated pleomorphic sarcoma local hyperthermia Chemotherapy R0 resection Case report

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Inductive heat property of Fe_3O_4 nanoparticles in AC magnetic field for local hyperthermia

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Rare Metals 2006年第Z1期25卷 621-625页

作者： ZHAO Donglin ZENG Xianwei XIA Qisheng TANG Jintian State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China Institute of Carbon Fiber and Composites Beijing University of Chemical Technology Beijing 100029 China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China Institute of Carbon Fiber and Composites Beijing University of Chemical Technology Beijing 100029 China Institute of Clinical Medical Sciences China-Japan Friendship Hospital Beijing 100029 China School of Medicine Tsinghua University Beijing 100084 China

Magnetite (Fe3O4) nanoparticles with different magnetic properties were prepared by coprecipitation of Fe3+ and Fe2+ with aqueous NaOH solution. The inductive heat properties of Fe3O4 nanoparticles in an alternating current (AC) magnetic field were investigated for local hyperthermia. The maximum saturation magnetization Ms of Fe3O4 nanoparticles is 65.53 emu·g-1 under the optimum conditions of Fe3+: Fe2+ molar ratio at 1.8:1. The Ms of Fe3O4 nanoparticles decreased as the Fe3+/Fe2+ molar ratio increased. But the coercivity Hc increases with the increasing of Fe3+/Fe2+ molar ratio. Exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspension containing Fe3O4 nanoparticles were 42-97.5 ℃. The inductive heat property of Fe3O4 nanoparticles in AC magnetic field decreases as Hc increases, but increases with the increasing of Ms. The Fe3O4 nanoparticles would be useful as good thermoseeds for localized hyperthermia treatment of cancers.

关键词： magnetite nanoparticles local hyperthermia cancer treatment biomedical applications

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