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The local control scheme for switching consensus value in multi-agent systems

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Journal of control and Decision 2015年第3期2卷 185-202页

作者： Miao Lin Lin-Lin Ou Ming Wang Lin Zhang Li Yu Department of Information Zhejiang University of TechnologyHangzhouChina

A local control strategy is presented to switch the consensus value for the first-order multi-agent system.When the local proportional controller is employed in the multiagent systems,the Laplacian matrix of the system is changed.It is proved that the changed Laplacian has the same properties as the Laplacian matrix of the original multi-agent system for the consensus.Based on this,the parameter of the local controller,which can guarantee that all the agents change the original consensus value into the desired one,is determined in terms of the matrix calculation and the stability criterion.In practice,the control system must be implemented in the discrete form.Thus,the influence of the sampling period on the stability of the discrete multi-agent system with the local controller is analysed.The simulation results show the validity of the proposed method.

关键词： multi-agent system local control consensus value stability

A New local control Spline with Shape Parameters for CAD/CAM

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Journal of Computer Science & Technology 1993年第3期8卷 280-288页

作者：秦开怀孙家广 Dept.of Computer Science and Technology.Tsinghua University Beijing 100084

A new local control spline based on shape parameters with G^2 continuity,called BLC-spline,is pro- posed.Not only is BLC-spline very smooth,but also the spline curve's characteristic polygon has only three control vertices,and the characteristic polyhedron has only nine control vertices.The behavior of lo- cal control of BLC-spline is better than that of the other splines such as cubic Bezier,B and Beta-spline.The three shape parameters β_0,β_1 and β_2 of BLC-spline,which are independent of the con- trol vertices,may be altered to change the shape of the curve or surface.It is shown that BLC-spline may be used to construct a space arc spline for DNC machining directly.That is a powerful tool for the design and manufacture of curves and surfaces in integrated CAD/CAM systems.

关键词： Spline curve surface control vertex characteristic polygon characteristic polyhedron shape parameter local control CAD/CAM

local control,SURVIVAL AND LATE TOXICITIES OF localLY ADVANCED NASOPHARYNGEAL CARCINOMA TREATED BY SIMULTANEOUS MODULATED ACCELERATED RADIOTHERAPY COMBINED WITH CISPLATIN CONCURRENT CHEMOTHERAPY THE LONG-TERM RESULTS OF A PHASE Ⅱ STUDY

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LOCAL CONTROL,SURVIVAL AND LATE TOXICITIES OF LOCALLY ADVANC...

Multi-institutional analysis of cervical esophageal carcinoma patients treated with definitive chemoradiotherapy: TROD 01-005 study

第六届全国鼻咽癌学术大会

作者： Wei-Wei Xiao,Shao-Min Huang,Fei Han,Shao-XiongWu,Li-Xia Lu,Cheng-Guang Lin,Xiao-Wu Deng,Tai-Xiang Lu,Nian-Ji Cui,Chong Zhao Department of Radiation Oncology,Cancer Center,Sun Yat-Sen University,Guangzhou,China

Purpose:The aim of this phaseⅡstudy was to determine the long-term local control,survival,and late toxicities among patients with locally advanced nasopharyngeal carcinoma(NPC) treated with intensity-modulated radiotherapy(IMRT) with the simultaneous modulated accelerated radiation therapy (SMART) boost technique and concurrent chemotherapy.Patients and methods:Eighty-one patients with pathologically diagnosed locally advanced NPC were enrolled in this study.IMRT was delivered with the SMART boost technique at prescribed doses of 68 Gy/30f to the nasopharynx gross target volume(GTV). Concurrent cisplatin chemotherapy(80 mg/m /day,on days 1 and 22) was administered.Results:The mean actual physical dose delivered to the GTVwas 73.8 Gy,and the mean biologically effective dose(BED) for the GTV was 84.8 Gy.With a median follow-up of 54 months,four patients experienced local recurrence (4.9%).The 5-year local control rate was 94.9%.Eighteen patients died.Among them,66.7%died of distant metastasis.The 5-year disease-free and overall survivals were 76.7%and 74.5%,respectively.The most common late toxicities among 68 patients with≥4 years follow-up were grade 1-2 xerostomia, hearing loss,skin dystrophy,and subcutaneous fibrosis.No grade 4 late toxicities were noted.Conclusions: IMRT with SMART to enhance BED and concurrent chemotherapy is feasible in patients with locally advanced NPC.Long-term results showed excellent local control with fewer late toxicities;although no further improvement was noted in overall survival,and the major cause of death was distant metastasis. Exploration of more effective combined chemoradiation strategies is warranted.

关键词： nasopharyngeal carcinoma simultaneous modulated accelerated radiotherapy local control survival late toxicity

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Oncology Research 2023年第3期31卷 299-306页

作者： OZAN CEM GULER EZGI OYMAK GOZDE YAZICI OZLEM OZKAYA AKAGUNDUZ OGUZ CETINAYAK PETEK ERPOLAT ATIL AKSOY MURSEL DUZOVA BERNA AKKUS YILDIRIM MERAL KURT EMINE CANYILMAZ GULER YAVAS SERAP AKYUREK DIDEM COLPAN OKSUZ ESRA KAYTAN SAGLAM OMUR KARAKOYUN CELIK ENIS OZYAR MUSTAFA CENGIZ CEM ONAL Department of Radiation Oncology Faculty of MedicineBaskent UniversityAdana Dr.Turgut Noyan Research and Treatment CenterAdanaTurkey Radiation Oncology Unit Iskenderun Gelisim HospitalHatayTurkey Department of Radiation Oncology Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineEge UniversityIzmirTurkey Department of Radiation Oncology Faculty of Medicine9 Eylul UniversityIzmirTurkey Department of Radiation Oncology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineAkdeniz UniversityAntalyaTurkey Department of Radiation Oncology Faculty of MedicineSelcuk UniversityKonyaTurkey Radiation Oncology Unit Prof.Dr.Cemil Tascioglu HospitalİstanbulTurkey Department of Radiation Oncology Faculty of MedicineUludag UniversityBursaTurkey Department of Radiation Oncology Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Department of Radiation Oncology Faculty of MedicineBaskent UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineAnkara UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineIstanbul University CerrahpasaIstanbulTurkey Radiation Oncology Unit Memorial Sisli HospitalIstanbulTurkey Department of Radiation Oncology Faculty of MedicineCelal Bayar UniversityManisaTurkey Department of Radiation Oncology Acibadem University Maslak HospitalIstanbulTurkey

The aim of this study was to examine the prognostic factors and treatment outcomes of cervical esophageal carcinoma(CEC)patients who underwent definitive chemoradiotherapy(CRT).The clinical data of 175 biopsyconfirmed CEC patients treated with definitive CRT between April 2005 and September 2021 were retrospectively analyzed.The prognostic factors predicting overall survival(OS),progression-free survival(PFS),and local recurrence-free survival(LRFS)were assessed in uni-and multivariable analyses.The median age of the entire cohort was 56 years(range:26–87 years).All patients received definitive radiotherapy with a median total dose of 60 Gy,and 52%of the patients received cisplatin-based concurrent chemotherapy.The 2-year OS,PFS,and LRFS rates were 58.8%,46.9%,and 52.4%,respectively,with a median follow-up duration of 41.6 months.Patients’performance status,clinical nodal stage,tumor size,and treatment response were significant prognostic factors for OS,PFS,and LRFS in univariate analysis.Non-complete treatment response was an independent predictor for poor OS(HR=4.41,95%CI,2.78–7.00,p<0.001)and PFS(HR=4.28,95%CI,2.79–6.58,p<0.001),whereas poor performance score was a predictor for worse LRFS(HR=1.83,95%CI,1.12–2.98,p=0.02)in multivariable analysis.Fifty-two patients(29.7%)experienced grade II or higher toxicity.In this multicenter study,we demonstrated that definitive CRT is a safe and effective treatment for patients with CEC.Higher radiation doses were found to have no effect on treatment outcomes,but a better response to treatment and a better patient performance status did.

关键词： Esophageal cancer Chemoradiotherapy Radiotherapy local control Toxicity Survival

Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma:A Rare Cancer Network study

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Chinese Journal of Cancer Research 2017年第6期29卷 521-532页

作者： Alessandra Franzetti Pellanda Berardino De Bari Elisabeth Deniaud-Alexandre MarcoKrengli Paul Van Houtte Antonella Riehetti Salvador Villa Hadassah Goldberg EwaSzutowiez-Zielifiska Michel Bolla Heidi Rutten Marc Van Eijkeren Philip Poortmans Guido Henke Yavuz Anaeak Steve Chan Christine Landmann Carine Kirkove LueianoScandolaro Jacques Bernier Rene-Olivier Mirimanof Mahmut Ozsahin Centre Hospitalier Universitaire Vaudois(CHUV) 1011 LausanneSwitzerland Clinica Luganese Moncucco 6903 LuganoSwitzerland Centre Hospitalier R6gional Universitaire"Jean Minjoz" INSERMUMR109825030 BesangonFrance Hopital Tenon 75970 ParisFrance Centre Hospitalier Departemental 85925 VendeeFrance degli Studi del Piemonte Orientale e Ospedale Maggiore della Carifi 28100 NovaraItaly University Institut Jules Bordet 1000 BrusselsBelgium 8Ospedale di Circolo 21100 VareseItaly Ospedale di Circolo 21100 VareseItalyt Istituto Oncologico della Svizzera Italiana EOC6500 BellinzonaSwitzerland Catalan Institute of Oncology Universitat Autbnoma de Barcelona08916 Barcelona 08916Spain Rambam Medical Center 31096 HaifaIsrael Medical University 80210 GdanskPoland Hopital Michallon BP21738043Grenoble cedex 09France Radboud University Medical Center 6525 NijmegenThe Netherlands Ghent University Hospital 9000 GentBelgium Institute Verbeeten 90120 TilburgThe Netherlands Kantonsspital St.Gallen 9007St.GallenSwitzerland Karadeniz Technical University 61080 TrabzonTurkey Nottingham University Hospital NHS trustNG5 1PB NottinghamUnited Kingdom Kantonsspital Basel 4031 BaselSwitzerland UCL St.Luc 1200 BrusselsBelgium presidio Ospedaliero Sant'Anna 22100 ComoItaly Ospedale San Giovanni 6500 BellinzonaSwitzerland Clinique de Genolier Genolier1272 Switzerland Department of Radiation Oncology Centre Hospitalier Universitaire Vaudois(CHUV)University of LausanneSwitzerland

Objective： Primary uterine leiomyosarcomas （ULMS） are rare, and the optimal treatment is controversial. We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS. Methods： We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network （RCN）. Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS, aged 18-80 years, complete International Federation of Gynecology and Obstetrics （FIGO） stage information, complete information on treatment, and a minimum follow-up of 6 months. local control （LC） and locoregional control （LRC）, overall survival （OS） and disease-free survival （DFS） rates were computed using the Kaplan-Meier method. Univariate analysis was implemented using the log rank test, and multivariate analysis using the Cox model. Results： All patients underwent surgery. Seventy-five patients （68%） received adjuvant radiotherapy （RT）, including brachytherapy in 18 （I 6%）. Seventeen patients （15 %） received adjuvant chemotherapy. Median follow-up was 58 （range, 6-240） months. Five-year OS and DFS rates were 50% and 34%, and LC and LRC rates were 88% and 72%, respectively. On multivariate analysis, independent favorable prognostic factors were younger age, FIGO stage I, small tumor size, previous uterine disease, and no vascular invasion for OS and DFS. FIGO stage was the only favorable factor influencing LRC. Adjuvant local or systemic treatments did not improve the outcomes. Eight patients treated with RT presented a grade 3 acute toxicity, and only one patient with grade 3 late toxicity. Conclusions： In this large population of primary ULMS patients, we found good results in terms of LC and LRC. Nevertheless, OS remains poor, mainly due to the occurrence of distant metastases. An early diagnosis seemed to improve the prognosis of the patients. Adjuvant local or systemic treatments, or more aggressive surgical procedures such as the Wertheim procedure, did not seem to impact the outcome.

关键词： Uterine leiomyosarcoma prognostic factors radiotherapy overall survival local control

Hepatocellular carcinoma with child Pugh-A Cirrhosis treated with stereotactic body radiotherapy

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World Journal of Gastrointestinal Surgery 2017年第12期9卷 256-263页

作者： Shaakir Hasan Ngoc Thai Tadahiro Uemura Vijay Kudithipudi Paul Renz Stephen Abel Alexander V Kirichenko Division of Radiation Oncology Allegheny General Hospital Cancer Institute Division of Transplant Surgery Allegheny General Hospital Cancer Institute

AIM To evaluate the control, survival, and hepatic function for Child Pugh(CP)-A patients after Stereotactic body radiotherapy(SBRT) in hepatocellular carcinoma(HCC).METHODS From 2009 to 2016, 40 patients with Barcelona Liver Clinic(BCLC) stages 0-B HCC and CP-A cirrhosis completed liver SBRT. The mean prescription dose was 45 Gy(40 to 50 Gy in 4-5 fractions). local relapse, defined as recurrence within the planning target volume was assessed with intravenous multiphase contrast computed tomography or magnetic resonance imaging every 4-6 mo after completion of SBRT. Progression of cirrhosis was evaluated by CP and Model for End Stage Liver Disease scores every 3-4 mo. Toxicities were graded per the Common Terminology Criteria for Adverse Events(v4.03). Median follow-up was 24 mo.RESULTS Forty-nine HCC lesions among 40 patients were analyzed in this IRB approved retrospective study. Median tumor diameter was 3.5 cm(1.5-8.9 cm). Six patients with tumors ≥ 5 cm completed planned selected transarterial chemoembolization(TACE) in combination with SBRT. Eight patients underwent orthotropic live transplant(OLT) with SBRT as a bridging treatment(median time to transplant was 12 mo, range 5 to 23 mo). The Pathologic complete response(PCR) rate in this group was 62.5%. The 2-year in-field local control was 98%(1 failure). Intrahepatic control was 82% and 62% at 1 and 2 years, respectively. Overall survival(OS) was 92% and 60% at 1 and 2 years, with a median survival of 41 mo per Kaplan Meier analysis. At 1 and 2 years, 71% and 61% of patients retained CPA status. Of the patients with intrahepatic failures, 58% developed progressive cirrhosis, compared to 27% with controlled disease(P = 0.06). Survival specific to hepatic failure was 92%, 81%, and 69% at 12, 18, and 24 mo. There was no grade 3 or higher toxicity. On univariate analysis, gross tumor volume(GTV) < 23 cc was associated with freedom from CP progression(P = 0.05), hepatic failure-specific survival(P = 0.02), and trended with OS(P = 0.10).CONCLUSION SBRT is safe

关键词： Stereotactic body radiotherapy Hepatocellular carcinoma Child-Pugh A Cirrhosis Hepatoma local control Radiotherapy Radiation

Sequential design and global optimization of local power system stabilizer and wide-area HVDC stabilizing controller

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Journal of Modern Power Systems and Clean Energy 2016年第2期4卷 292-299页

作者： Yong LI Fang LIU Yijia CAO College of Electrical and Information Engineering Hunan UniversityChangsha 410082China School of Information Science and Engineering Central South UniversityChangsha 410083China

A sequential design and global optimization method is proposed to coordinately design local and widearea controllers to enhance the overall stability of largescale power system.The sequential design is used to assign the distributed local power system stabilizer (LPSS) and high-voltage direct current (HVDC) wide-area stabilizing controller (HVDC-WASC) to the concerned damping modes.The global optimization is used to simultaneously optimize all the overall control gains of LPSSs and HVDCWASC.Moreover,the optimization model,which has an adaptive ability of searching and updating dominant oscillation modes,is established.Both the linear analysis and nonlinear simulation results verify the effectiveness of the proposed design method in enhancing the stability of large-scale power systems.

关键词： local control Wide-area control(WAC) local power system stabilizer(LPSS) High-voltage direct current(HVDC) Wide-area stabilizing control(WASC)

Management of breast cancer brain metastases: Focus on human epidermal growth factor receptor 2-positive breast cancer

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Chronic Diseases and Translational Medicine 2017年第1期3卷 -页

作者： Peng Yuan Song-Lin Gao National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

After the introduction of trastuzumab, a monoclonal antibody that binds to human epidermal growth factor receptor 2 (HER2), the overall survival (OS) among patients with HER2-positive breast cancer has been substantially improved. However, among these patients, the incidence of brain metastases (BM) has been increasing and an increased proportion of them have died of intracranial progression, which makes HER2-positive breast cancer brain metastases (BCBM) a critical issue of concern. For local control of limited BM, stereotactic radiosurgery (SRS) and surgical resection are available modalities with different clinical indications. Postoperative or preoperative radiation is usually delivered in conjunction with surgical resection to boost local control. Adjuvant whole-brain radiotherapy (WBRT) should be deferred for limited BM because of its impairment of neurocognitive function while having no benefit for OS. Although WBRT is still the standard treatment for local control of diffuse BM, SRS is a promising treatment for diffuse BM as the technique continues to improve. Although large molecules have difficulty crossing the blood brain barrier, trastuzumab-containing regimens are critical for treating HER2-positive BCBM patients because they significantly prolong OS. Tyrosine kinase inhibitors are more capable of crossing into the brain and they have been shown to be beneficial for treating BM in HER2-positive patients, especially lapatinib combined with capecitabine. The antiangiogenic agent, bevacizumab, can be applied in the HER2-positive BCBM scenario as well. In this review, we also discuss several strategies for delivering drugs into the central nervous system and several microRNAs that have the potential to become biomarkers of BCBM.

关键词： Breast cancer brain metastases Human epidermal growth factor receptor 2-positive breast cancer local control MicroRNA Targeted therapy

Vision-based formation control of mobile robots

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控制理论与应用（英文版） 2005年第2期3卷 173-180页

作者： Shicai LIU Dalong TAN Guangjun LIU Shenyang Institute of Automation Chinese Academy of Sciences Shenyang Liaoning 110016 China Graduate School Chinese Academy of Sciences Beijing 100049 China Department of Aerospace Engineering Ryerson University Toronto Canada MSB 2K3

In this paper, a formation control algorithm and an obstade avoidance control algorithm for mobile robots are developed based on a relative motion sensory system such as a pan/tilt camera vision system, without the need for global sensing and between robots. This is achieved by employing the velocity variation, instead of actual velocities, as the control inputs. Simulation and experimental results have demonstrated the effectiveness of the proposed control methods.

关键词： Formation control Obstacle avoidance Mobile robot local control Rehtive motion states