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lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling

引用

World Journal of Gastrointestinal Oncology 2022年第1期14卷 253-264页

作者： Wei Zheng Guo-Liang Shen Ke-Yang Xu Qiao-Qiao Yin Tian-Chen Hui Zhe-Wen Zhou Cheng-An Xu Shou-Hao Wang Wen-Hao Wu Ling-Fei Shi Hong-Ying Pan Department of Clinical Medicine Medical College of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Infectious Diseases Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Hepatobiliary&Pancreatic Surgery and Minimally Invasive Surgery Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina School of Chinese Medicine Hongkong Baptist universityHong Kong 999777China Department of Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Medical Department of Qingdao University Qingdao UniversityQingdao 266071ShandongChina Diagnosis and Treatment Center of Osteoporosis Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHang Zhou 310014Zhejiang ProvinceChina

BACKGROUND Liver cancer is one of the most highly malignant cancers,characterized by easy metastasis and chemoradiotherapy resistance.Emerging evidence indicates that long noncoding RNAs(lncRNAs),including lnc524369,are highly involved in the initiation,progression,radioresistance,and chemoresistance of hepatocellular carcinoma(HCC).However,the function of lnc524369 remains unclear.AIM To explore the function of lnc524369 in HCC.METHODS To investigate the effect of lnc524369,tissue from 41 HCC patients were analyzed using CCK8,migration,and invasion assays.lnc524369 and YWHAZ(also named 14-3-3ζ)mRNA were detected by qPCR,and YWHAZ and RAF1 proteins were detected by western blot in liver cancer cell lines and human HCC tissues.The Cancer Cell Line Encyclopedia(CCLE)databases,STRING database,Human Protein Atlas database,and the TCGA database were used for bioinformatic analysis.RESULTS lnc524369 was significantly upregulated in the nucleus of liver cancer cells and human HCC tissues.Overexpression of lnc524369 was associated with the proliferation,migration,and invasion of liver cancer cells.YWHAZ and RAF1 proteins and YWHAZ mRNA were overexpressed in liver cancer,which could be attenuated by overexpression of lnc524369.lnc524369 and its downstream target YWHAZ and RAF1 proteins were negatively associated with overall survival time.CONCLUSION lnc524369 might be a promising target of HCC as it can enhance liver cancer progression and decrease the overall survival time of HCC by activating the YWHAZ/RAF1 pathway.

关键词： Long noncoding RNAs lnc524369 Hepatocellular carcinoma YWHAZ RAF1

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