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lnc-tcl6 is a potential biomarker for early diagnosis and grade in liver-cirrhosis patients

Gastroenterology Report 2019年第6期7卷 434-443,I0002页

作者： Lei-Jia Li Xiao-Ying Wu Si-Wei Tan Zi-Jun Xie Xue-Mei Pan Shun-Wen Pan Wu-Ri-Na Bai Hai-Jiao Li Hui-Ling Liu Jie Jiang Bin Wu Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Liver Disease Research GuangzhouGuangdongP.R.China Department of Laboratory Medicine The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Long non-coding RNAs(lncRNAs)have been applied as biomarkers in many ***,scarce biomarkers are available in single lncRNA differential expression associated with different clinical stages of liver cirrhosis(LC).The aim of the study is to identify some lncRNAs that can serve as non-invasive sensitive biomarkers for early diagnosis and grade of ***:Blood lncRNA expression was evaluated in three independent cohorts with 305 participants including healthy controls,hepatitis B virus(HBV)carriers,and patients with chronic hepatitis B(CHB)or ***,candidate lncRNAs were screened by CapitalBiotech microarray to diagnose *** reverse-transcriptase polymerase chain reaction was then used to investigate the expression of selected lncRNAs in the whole group of cirrhosis and different Child–Pugh ***,the diagnostic accuracy of the promising biomarker was examined and validated via Mann–Whitney test and receiver-operating characteristics ***:lnc-tcl6 was identified as a sensitive biomarker for early diagnosis of LC(Child–Pugh A)compared with healthy controls(area under the ROC curve[AUC]=0.636),HBV carriers(AUC=0.671),and CHB patients(AUC=0.672).Furthermore,lnc-tcl6 showed a favourable capacity in discriminating among different Child–Pugh classes(AUC:0.711–0.837).Compared with healthy controls,HBV carriers,and CHB patients,the expression of lnc-tcl6 was obviously up-regulated in Child–Pugh A patients and,conversely,significantly down-regulated in Child–Pugh C ***:lnc-tcl6 is a novel potential biomarker for early diagnosis of LC and is a possible predictor of disease progression.

关键词： long non-coding RNAs lnc-tcl6 biomarker liver cirrhosis Child–Pugh classification

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