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living Electrospun short Fibrous Sponge via Engineered Nanofat for Wound Healing

Advanced Fiber Materials 2023年第3期5卷 979-993页

作者： Xiaohan Fu Juan Wang Dejian Qian Zhaowen Chen Liang Chen Wenguo Cui Yan Wang Department of Plastic Surgery Key Laboratory of Birth Regulation and Control Technology of National Health Commission of ChinaShandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014People’s Republic of China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai 200025People’s Republic of China Department of Orthopedic Surgery The First Affliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250014People’s Republic of China Department of Obstetric Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014People’s Republic of China

living cells and active factors are the two core elements of tissue repair,directly affecting the healing efficiency of damaged ***(NF)can release living cells,such as adipose-derived stem cells(ADSCs),as well as active growth factors to promote angiogenesis,thus realizing cell-based wound ***,a novel living electrospun short fibrous sponge is constructed by modifying three-dimensional(3D)bionic short fibers with engineered *** uniform distribution of the polydopamine(PDA)modification endows the living sponges with stable mechanical properties,reversible water absorption and excellent adhesion even after repeated compression by an external force and long-term aqueous ***,the living electrospun short fibrous sponges with uniform NF modification contain living cells such as ADSCs and active growth factors such as vascular endothelial growth factor(VEGF),which can effectively promote the tube formation of human umbilical vein endothelial cells(HUVECs).In vivo,the living sponges can effectively and continuously act on wounds and act as a bionic living skin to prevent the loss of internal nutrients,creating a comfortable and favorable microenvironment for tissue regeneration and promoting the healing of diabetic ***,living electrospun short fibrous sponges via engineered NF are expected to achieve continuous wound healing with in situ living cells and active factors in injured tissues.

关键词： Electrospun Nanofibers Engineered nanofat living short fibers Wound healing

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