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Revisiting the liver’s role in transplant alloimmunity

World Journal of Gastroenterology 2019年第25期25卷 3123-3135页

作者： Nitin Abrol Caroline C Jadlowiec Timucin Taner William J.von Liebig Center for Transplantation and Clinical Regeneration Massyo ClinicRochesterMN 55905United States Transplant Center Mayo ClinicPhoenixAZ 85259United States

The transplanted liver can modulate the recipient immune system to induce tolerance after *** phenomenon was observed nearly five decades ***,the liver’s role in multivisceral transplantation was recognized,as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and *** liver has a unique architecture and is home to many cells involved in immunity and *** transplantation,these cells migrate from the liver into the *** studies identified chimerism as an important mechanism by which the liver modulates the human immune *** studies on human T-cell subtypes,cytokine expression,and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying *** this article,we discuss the privileged state of liver transplantation compared to other solid organ transplantation,the liver allograft’s role in multivisceral transplantation,various cells in the liver involved in immune responses,and the potential mechanisms underlying immunomodulation of host alloresponses.

关键词： liver transplantation Alloimmunity liver-kidney transplant Tolerance Rejection

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Orthotopic liver transplantation in treatment of 77patients with end-stage hepatic disease

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 8-13页

作者： Zheng S.-S. Huang D.-S. Wang W.-L. Liang T.-B. Zhang M. Shen Y. Xu X. Wu J. Yan S. Guo H. Lu A.-W. Dept. of Hepatobiliary Surgery First Affiliated Hospital Zhejiang University School of Med. Hangzhou 310003 China

Objective: To summarize the experience of human or-thotopic liver transplantation(OLTx) in treatment ofpatients with end-stage hepatic disease and their peri-operative ***: A retrospective analysis was made on OLTxperformed in 77 patients from April 1993 to September2001 in our department included combined liver-kid-ney transplantation (6 patients) and living related livertransplantation (2). Among them, 76 were adults and1 was infant (67 males and 10 females) . The donors in-cluded 7S non-heart beating donors and 2 living re-lated donors. Veno-venous bypass was used only in 45cases during the operation. Immunosuppressive agentsconsisted of cyclosporine, cellcept, ALG corticosteroidsand ***: The one-year survival rates of grafts and re-cipients with benign hepatic disease were 75%. Therecipients this year are surviving with good function ***: liver transplantation is the best therapeu-tic method for a large number of patients with end-stage hepatic disease in China.

关键词： orthotopic liver transplantation combined liver-kidney transplantation living related liver transplantation

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