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Correlation analysis of liver tumor-associated genes with liver regeneration

World Journal of Gastroenterology 2007年第24期13卷 3323-3332页

作者： Cun-Shuan Xu Shou-Bing Zhang Xiao-Guang Chen Salman Rahman College of Life Science Henan Normal University Xinxiang 453007 Henan Province China Key Laboratory for Cell Differentiation Regulation Xinxiang 453007 Henan Province China Laboratory of Thrombosis and Vascular Remodelling Division of Cardiovascular Medicine King's College London School of Medicine St Thomas' Hospital Lambeth Palace Road London SE1 7EH United Kingdom

AIM: To study at transcriptional level the similarities and differences of the physiological and biochemical activities between liver tumor (LT) and regenerating liver cells. METHODS: LT-associated genes and their expression changes in LT were obtained from databases and scientific articles, and their expression profiles in rat liver regeneration (LR) were detected using Rat Genome 230 2.0 array. Subsequently their expression changes in LT and LR were compared and analyzed. RESULTS: One hundred and twenty one LT-associated genes were found to be LR-associated. Thirty four genes were up-regulated, and 14 genes were down-regulated in both LT and regenerating liver; 20 genes up-regulated in LT were down-regulated in regenerating liver; 21 up-regulated genes and 16 down-regulated genes in LT were up-regulated at some time points and down-regulated at others during LR. CONCLUSION: Results suggested that apoptosis activity suppressed in LT was still active in regenerating liver, and there are lots of similarities and differences between the LT and regenerating liver at the aspects of cell growth, proliferation, differentiation, migration and angiogenesis.

关键词： Partial hepatectomy Rat Genome 230 2.0Array Apoptosis liver regeneration-associated gene liver tumor-associated gene

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