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Does ischemia-free machine perfusion lead to early allograft dysfunction (EAD) free liver transplantation?

Hepatobiliary Surgery and Nutrition 2024年第4期13卷 678-680页

作者： Hani M.Wadei Kristopher P.Croome Division of Kidney and Pancreas transplant Department of TransplantMayo ClinicJacksonvilleFLUSA Division of transplant Surgery Department of TransplantMayo ClinicJacksonvilleFLUSA

Normothermic machine perfusion(NMP)is an innovative technique used in solid organ transplantation that involves perfusing the organ with specialized solution or leukocyte depleted red blood cells at near-normal body temperature aiming at mimicking physiological conditions,and providing optimal conditions for organ preservation which leads to reduced risk of ischemia reperfusion injury(IRI)when compared to the standard static cold storage(SCS)(1).One of the key advantages of NMP is its ability to assess the quality of the organ in real-time and assessment of the organ performance prior to *** continuously monitoring parameters such as blood flow,oxygen consumption,and lactate production,clinicians can evaluate the viability of the organ and make more informed decisions about its suitability for *** real-time assessment can help reduce the risk of transplanting organs that may not function optimally or have a higher likelihood of complications ***,NMP may expand the pool of donor organs by allowing for the use of organs that may have been deemed marginal or unsuitable for transplantation using traditional methods(1,2).

关键词： Early allograft dysfunction(EAD) normothermic machine perfusion(NMP) liver transplant outcomes

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Assessment of advanced age candidates for liver transplantation warrants more caution

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World Journal of transplantation 2022年第2期12卷 24-26页

作者： Alessandro Parente Vincenzo Ronca liver Unit Queen Elizabeth Hospital University Hospital Birmingham NHS Foundation TrustBirmingham B152THUnited Kingdom Centre for liver and Gastrointestinal Research Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom

For patients with fulminant liver failure and end-stage liver disease,liver transplantation remains the only effective *** the years,as a result of the ageing population,the average age of liver transplant donors and recipients has increased and currently about one quarter of patients receiving transplantation in the United States are above the age of ***,a study reported that patients aged 65 years or older had lower one-year survival compared to a younger ***,we express our opinion about this interesting publication.

关键词： liver transplantation Elderly patients Age in liver transplantation Frailty transplant assessment liver transplant outcomes

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