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The role of roof plate-specific spondins in liver homeostasis and disease

liver Research 2022年第3期6卷 139-145页

作者： Le Yang Wenhui Yue Hang Zhang Yue Gao Lin Yang Liying Li Department of Cell Biology Municipal Laboratory for Liver Protection and Regulation of RegenerationCapital Medical UniversityBeijingChina

As evolutionarily conserved signals,roof plate-specific spondins(R-spondins;RSPOs)are a family with four members(RSPO1e4)exerting distinctly different *** have five receptors and correlate with different signaling pathways through these receptors and then perform various ***,their best-known molecular function is the capacity to enhance WNT signaling pathways,which play critical roles in several processes.A recent study shows that RSPOs not only potentiate the WNT/beta(b)-catenin signaling pathway but are also involved in the WNT/planar cell polarity signaling *** influence liver homeostasis and the development of multiple liver ***1 increases cell proliferation,protects hepatocytes from injury,improves liver regenerative potential,and affects liver metabolic ***2 not only regulates proliferation-associated genes and promotes differentiation in the liver but also participates in liver fibrosis through the WNT/b-catenin signaling ***3 is a key determinant of proper liver function,such as promoting hepatocyte regeneration and maintaining liver ***3 is upregulated in liver fibrosis and livers of patients with nonalcoholic ***,RSPO2 and RSPO3 are confirmed as oncogenes and involved in the occurrence of liver *** role of RSPO4 in the liver remains *** this review,the structural and biochemical properties of RSPOs and their receptors and their roles in liver homeostasis and disease are summarized.

关键词： Roof plate-specific spondin(RSPO) Leucine-rich repeat-containing G-proteincoupled receptor(LGR) Zinc and ring finger 3(ZNRF3) Ring finger protein 43(RNF43) WNT signaling pathway liver homeostasis liver fibrosis liver cancer

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The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier

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Food Science and Human Wellness 2024年第2期13卷 999-1010页

作者： Dejiang Xue Shuai Jiang Miao Zhang Kai Shan RenéLametsch Chunbao Li Key Laboratory of Meat Processing and Quality Control Ministry of EducationKey Laboratory of Meat ProcessingMinistry of Agriculture and Rural AffairsJiangsu Collaborative Innovation Center of Meat ProductionProcessing and Quality ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China Department of Food Science University of CopenhagenFrederiksberg C DK-1958Denmark

Hemoglobin hydrolysate is derived from the enzymatic degradation of *** work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content,iron circulation,and liver *** found that hemoglobin hydrolysate promoted the absorption of non-heme iron with high efficiency in duodenum by spontaneously binding non-heme iron during digestion,and increased hepatic iron content by up-regulating divalent metal transporter 1,zinc transporter 14,but hepatic iron content only increased at 3 *** iron entered the blood through ferroportin without restriction at 3 weeks,and excessive iron entered the liver and then affected the hepatocyte membranes permeability and lipid synthesis through oxidative *** the prolongation of dietary intervention,the up-regulated hepcidin acted on the ferroportin to restrict excess iron from entering the blood,and then the hepatic homeostasis *** addition,hemoglobin hydrolysate enhanced the hepatic antioxidant *** together,hemoglobin hydrolysate has a strong ability to promote the absorption of non-heme iron in vivo,and the absorbed iron is relatively safe due to the regulation of hepcidin.

关键词： Hemoglo bin hydrolysate Non-heme iron Absorption liver homeostasis Hepcidin

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