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Usefulness of Y-shaped sheaths in CT angiography for examination of liver tumors

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World Journal of Gastroenterology 2010年第37期16卷 4704-4708页

作者： Toru Ishikawa Kazuo Higuchi Tomoyuki Kubota Kei-ichi Seki Terasu Honma Toshiaki Yoshida Takeo Nemoto Keiko Takeda Tomoteru Kamimura Department of Gastroenterology and Hepatology Saiseikai Niigata Second Hospital Department of Radiology Saiseikai Niigata Second Hospital

AIM: To conduct a single-stage, combined computed tomography (CT) arterial portography (CTAP) and CT arteriography (CTA) imaging operation, we used Y-shaped sheaths with 2 valves, which allowed the insertion of 2 catheters simultaneously. METHODS: Of 1254 patients who underwent abdominal angiography for transarterial embolization and/or intraarterial chemotherapy in our department from May 2002 to November 2009, 664 patients in whom Y-shaped sheaths with 2 valves were used underwent CT angiography using a combination of CTA and CTAP. The Seldinger method was used to insert a 10 cm Y-shaped short sheath with 2 valves into the femoral artery. Under radiographic guidance, a 3.2 French (Fr) catheter was placed in the celiac artery or proper hepatic artery, and a second 3.2 Fr catheter was then placed distal to the inferior pancreaticoduodenal artery of the superior mesenteric artery. CTAP was then performed followed by CTA 10 min later. Photographs were taken during the early and late phases of the ***: Insertion of 3.2 Fr catheters was not possible in 6 of 664 (0.9%) patients with strong curvature of the femoral artery and 4 of 664 (0.6%) patients with strong curvature of the abdominal aorta. In addition, performing CTAP and CTA as a single-stage combined intervention was not possible in 14 of 664 (2.1%) patients whose right hepatic artery originated from the superior mesenteric artery and in 8 of 664 (1.2%) patients whose left hepatic artery branched from the left gastric artery. There were no sheath-related complications such as those related to arterial dissection or hemostasis. CONCLUSION: Although transfers to and from the CT room were necessary for anatomically variant patients, CT angiography using the Y-shaped sheath for combined CTAP and CTA was considered useful.

关键词： Computed tomography angiography Interventional radiology liver tumors

Functional CT for assessment of early vascular physiology in liver tumors

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Hepatobiliary & Pancreatic Diseases International 2008年第5期7卷 497-502页

作者： Jiang, Hui-Jie Zhang, Zai-Ren Shen, Bao-Zhong Wan, Yong Guo, Hong Shu, Sheng-Jie Harbin Med Coll Affiliated Hosp 4 Dept Med Imaging Harbin 150001 Peoples R China Harbin Med Coll Affiliated Hosp 2 CT Room Harbin 150086 Peoples R China

BACKGROUND: CT perfusion has been reported to have great advantages in detecting hepatic diseases. However, currently there are no studies showing the potential value of multi-slice CT perfusion with the deconvolution model method in diagnosing early hemodynamic changes caused by liver tumors. This study was undertaken to determine if early hemodynamic changes caused by liver tumors can be depicted with the perfusion imaging of multi-slice CT. METHODS: Ten New Zealand white rabbits before and after VX2 liver tumor inoculation served as the experimental animals. Ten normal rabbits served as controls. All underwent multi-slice CT perfusion for the measurement of hepatic blood flow (HBF), hepatic blood volume (HBV), mean transit time (MTT), permeability of capillary vessel surface (PS) and hepatic artery index (HAI). RESULTS: With the exception of MTT, which decreased significantly at the tumor periphery, HBF, HBV,. PS and HAI increased significantly compared with the surrounding normal tissue. All these changes occurred at days 5-9 after tumor inoculation. Statistically significant changes in these values were detected with tumor growth. CONCLUSIONS: The hemodynamic changes in the liver caused by rabbit VX2 liver tumor can be detected after tumor inoculation, and functional CT can evaluate the physiological characteristics of early tumor angiogenesis.

关键词： liver tumors computed tomography hemodynamics animal model

Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study

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World Journal of Gastroenterology 2007年第47期13卷 6356-6364页

作者： EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung Department of Diagnostic Radiology University Hospital RegensburgFranz-Josef Strauss-Allee 11Regensburg 93043Germany Department of Radiology Ultrasound SectionGroβhadern HospitalLudwig Maximilian University of MunichMarchioninistr15Mnchen 81377Germany Department of Trauma Surgery Passau HospitalInnstraβe 76Passau 94034Germany Institutes of Radiology Nuclear Medicine and UltrasoundPirmasens HospitalGermany Center for Biomaterial Development Institute of Polymer ResearchGKSSKantstr55Teltow 14513Germany

AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the poss

关键词： liver tumors Malignant tumor Contrast harmonic imaging Quantitative contrast enhancement

Endoscopic ultrasound-guided tissue acquisition for the diagnosis of focal liver lesion

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World Journal of Radiology 2024年第4期16卷 72-81页

作者： Alina Tantău Cosmina Sutac Anamaria Pop Marcel Tantău Department of Internal Medicine and Gastroenterology “Iuliu Hatieganu”University of Medicine and PharmacyThe 4th Medical Clinic CF HospitalCluj-Napoca 400012ClujRomania Department of Gastroenterology “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162ClujRomania Department of Gastroenterology and Hepatology Gastroenterology and Hepatology Medical CenterDigenio HospitalCluj-Napoca 400058ClujRomania Department of Internal Medicine and Gastroenterology “Iuliu Hatieganu”University of Medicine and Pharmacy“Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162ClujRomania

In patients with liver tumors,the histopathology examination can assist in diagnosis,staging,prognosis,and therapeutic management *** ultrasound(EUS)-guided tissue acquisition using fine needle aspiration(FNA)or more newly fine needle biopsy(FNB)is a well-developed technique in order to evaluate and differentiate the liver *** goal of the EUS-FNA or EUS-FNB is to provide an accurate sample for a histopathology ***,malignant tumors such as hepatocarcinoma,cholangiocarcinoma and liver metastasis or benign tumors such as liver adenoma,focal hyperplastic nodular tumors and cystic lesions can be accurately diagnosed using EUS-guided tissue ***-FNB using 19 or 22 Ga needle provide longer samples and a higher diagnostic accuracy in patients with liver masses when compared with *** data are available on the diagnostic accuracy of EUS-FNB when compared with percutaneously,ultrasound,computer tomography or transjugulary-guided liver *** review will discuss the EUS-guided tissue acquisition options in patients with liver tumors and its efficacy and safety in providing accurate *** results of the last studies comparing EUS-guided liver biopsy with other conventional techniques are *** EUS-guided tissue acquisition using FNB can be a suitable technique in suspected liver lesions in order to provide an accurate histopathology diagnosis,especially for those who require endoscopy.

关键词： Endoscopic ultrasound-guided liver biopsy liver tissue acquisition Fine-needle aspiration Fine-needle biopsy liver tumors Focal liver lesions

Risk factors for post-hepatectomy liver failure in 80 patients

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World Journal of Clinical Cases 2021年第8期9卷 1793-1802页

作者： Ying Xing Zheng-Rong Liu Wei Yu Hong-Yi Zhang Mao-Min Song Department of General Surgery Tiantan HospitalBeijing 100170China

BACKGROUND Post-hepatectomy liver failure(PHLF)is a serious complication and a leading cause of death after hepatectomy,an accurate prediction of PHLF is important for improvement of prognosis after *** To retrospectively analyze the risk factors for postoperative liver failure in patients undergoing hepatectomy for liver *** The clinical data of 80 patients undergoing hepatectomy in our hospital from June 2018 to January 2020 were *** laboratory examination as well as preand post-operative abdominal three-dimensional reconstructive computed tomography,the demographic data,surgical data,biochemical indicators,coagulation index,routine blood tests,spleen and liver volumes,relative remnant liver volume,and other related indicators were obtained and compared between patients with PHLF and those without *** PHLF occurred in 19(23.75%)*** logistic regression analysis showed that gender,history of hepatitis/cirrhosis,and preoperative bilirubin,albumin,coagulation function,albumin-bilirubin ratio,aspartate aminotransferase-to-platelet ratio index(APRI),Model for End-Stage liver Disease score,spleen volume(SV),spleen volume/liver volume ratio(SV/LV),and relative remnant liver volume were statistically associated with the occurrence of PHLF(all Pliver resection,preoperative total bilirubin,PLT,APRI,and SV/LV are independent risk factors for *** findings may provide guidance to safely perform liver surgery in such patients.

关键词： Hepatectomy liver failure liver tumors Risk factors

liver Tumor Prediction with Advanced Attention Mechanisms Integrated into a Depth-Based Variant Search Algorithm

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Computers, Materials & Continua 2023年第10期77卷 1209-1226页

作者： P.Kalaiselvi S.Anusuya Department of Computer Science and Engineering Saveetha School of EngineeringChennaiTamil Nadu602117India Information Technology Saveetha School of EngineeringChennaiTamil Nadu602117India

In recent days,Deep Learning(DL)techniques have become an emerging transformation in the field of machine learning,artificial intelligence,computer vision,and so ***,researchers and industries have been highly endorsed in the medical field,predicting and controlling diverse diseases at specific *** tumor prediction is a vital chore in analyzing and treating liver *** paper proposes a novel approach for predicting liver tumors using Convolutional Neural Networks(CNN)and a depth-based variant search algorithm with advanced attention mechanisms(CNN-DS-AM).The proposed work aims to improve accuracy and robustness in diagnosing and treating liver *** anticipated model is assessed on a Computed Tomography(CT)scan dataset containing both benign and malignant liver *** proposed approach achieved high accuracy in predicting liver tumors,outperforming other state-of-the-art ***,advanced attention mechanisms were incorporated into the CNN model to enable the identification and highlighting of regions of the CT scans most relevant to predicting liver *** results suggest that incorporating attention mechanisms and a depth-based variant search algorithm into the CNN model is a promising approach for improving the accuracy and robustness of liver tumor *** can assist radiologists in their diagnosis and treatment *** proposed system achieved a high accuracy of 95.5%in predicting liver tumors,outperforming other state-of-the-art methods.

关键词： Deep learning convolution neural networks liver tumors CT scans attention mechanism classifier

Primary hepatic solitary fibrous tumor with histologically benign and malignant areas

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Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 665-668页

作者： Anna Silvanto Nariman D Karanjia Izhar N Bagwan Departments of Histopathology Royal Surrey County Hospital General Sugery Royal Surrey County Hospital

Extrapleural solitary fibrous tumor （SFT） is an uncommon mesenchymal neoplasm, presenting most commonly in the intrathoracic sites but which has been reported at nu- merous extrathoracic locations. The majority of intra-thoracic SFTs are benign, but 10%-15% behave aggressively. We report a case of primary hepatic SFT with histologically benign and ma- lignant areas. A 65-year-old man underwent an abdominal CT scan following a cerebrovascular accident, which demonstrated a sharply demarcated large liver mass with a heterogenous enhancing area and occupying most of the left lobe of the liver. Histological examination following a hemihepatectomy showed an SFT with morphological patterns ranging from benign to malignant areas, including pleomorphism, increased cellularity, herringbone pattern, necrosis and a raised mitotic count. On review of the literature, only an occasional case report with malignant areas in a hepatic SFT was identified. This case highlights that SFT should be included in the differential diagnosis of a hepatic spindle cell lesion, and that on rare occasions, malignant areas can occur in this already uncommon neoplasm.

关键词： liver tumors malignant (non-HCC) liver surgery pathological changes

Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review

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World Journal of Gastroenterology 2014年第29期20卷 10137-10143页

作者： Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado Department of Surgery Reina Sofia Hospital Department of Pediatric Surgery Reina Sofia Hospital Department of Pediatric Oncology Reina Sofia Hospital

AIM: To report our experience with long-term outcomes after multimodal management therapy.

关键词： liver tumors Chemotherapy liver surgery Multimodal management

liver Tumor Decision Support System on Human Magnetic Resonance Images:A Comparative Study

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Computer Systems Science & Engineering 2023年第8期46卷 1653-1671页

作者： Hiam Alquran Yazan Al-Issa Mohammed Alslatie Isam Abu-Qasmieh Amin Alqudah Wan Azani Mustafa Yasmin Mohd Yacob Department of Biomedical Systems and Informatics Engineering Yarmouk University 556Irbid21163Jordan Department of Biomedical Engineering Jordan University of Science and TechnologyIrbid22110Jordan Department of Computer Engineering Yarmouk University 556Irbid21163Jordan The of Biomedical Technology King Hussein Medical CenterRoyal Jordanian Medical ServiceAmman11855Jordan Faculty of Electrical Engineering&Technology Campus Pauh PutraUniversiti Malaysia PerlisArau02600PerlisMalaysia Faculty of Electronic Engineering&Technology Campus Pauh PutraUniversiti Malaysia PerlisArau02600PerlisMalaysia Advanced Computing Centre of Excellence(CoE)Universiti Malaysia PerlisArau02600PerlisMalaysia

liver cancer is the second leading cause of cancer death *** tumor detection may help identify suitable treatment and increase the survival *** imaging is a non-invasive tool that can help uncover abnormalities in human *** Resonance Imaging(MRI),in particular,uses magnetic fields and radio waves to differentiate internal human organs ***,the interpretation of medical images requires the subjective expertise of a radiologist and ***,building an automated diagnosis computer-based system can help specialists reduce incorrect *** paper proposes a hybrid automated system to compare the performance of 3D features and 2D features in classifying magnetic resonance liver tumor *** paper proposed two models;the first one employed the 3D features while the second exploited the 2D *** first system uses 3D texture attributes,3D shape features,and 3D graphical deep descriptors beside an ensemble classifier to differentiate between four 3D tumor *** top of that,the proposed method is applied to 2D slices for comparison *** proposed approach attained 100%accuracy in discriminating between all types of tumors,100%Area Under the Curve(AUC),100%sensitivity,and 100%specificity and precision as well in 3D liver *** the other hand,the performance is lower in 2D *** maximum accuracy reached 96.4%for two classes and 92.1%for four *** top-class performance of the proposed system can be attributed to the exploitation of various types of feature selection methods besides utilizing the ReliefF features selection technique to choose the most relevant features associated with different *** novelty of this work appeared in building a highly accurate system under specific circumstances without any processing for the images and human input,besides comparing the performance between 2D and 3D *** the future,the presented work can be extended to be

关键词： liver tumors ensemble classifier 3D shape features 3D cooccurrence matrix ResNet101