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Hepatoprotective Effect of Costus Roots Extract against Carbon Tetrachloride （CCI4）-Induced liver Injury in Guinea Pigs

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Journal of Life Sciences 2017年第4期11卷 176-184页

作者： Mohamed Ali Hasan Al-Duais Yahya Saleh Mohamed Al-Awthan Department of Biochemistry Faculty of Science University of Tabuk Tabuk 71491 Saudi Arabia Department of Biology Faculty of Science lbb University Ibb 70270 Yemen Department of Chemistry Faculty of Science Ibb University lbb 70270 Yemen

SC （Saussurea costus）（Asteraceae） is a traditionally known and potent plant which is well considered for its medicinal uses in different indigenous Indian systems of medicine. This study was undertaken to investigate the hepatoprotective effect of SC against liver injury induced by CC14 intoxication. Animals were divided into five groups. Group I, served as normal control. Group II received 2 mL CC14/kg b.w. diluted with olive oil, at 1：1 ratio on day 11. Groups III and IV were pre-treated orally respectively with 100 and 200 mg/kg b.w. aqueous roots extract of SC for 10 days followed by subcutaneous injection of CC14 （2 mL/kg b.w.）, once on day 11. Group V were orally given liv-52 （100 mg/kg b.w.） once daily for 10 days followed by subcutaneous injection of CC14 （2 mL/kg b.w.）, once on day 11. Our results show that, the activity of serum hepatic enzymes （ALT, AST, and ALP） were significantly elevated in guinea pigs treated with CC14, while both the SC root extract and liv-52 reduced significantly these enzymes activity. Also, the levels of glucose, urea and cholesterol were decreased when compared with intoxicated control. Histopathological examination of intoxicated animals showed dilation, hemorrhage, vacuolization, inflammation and necrosis indicating liver damage, while the animals received SC or liv-52 that showed less pathological effects or normal liver when compared to animals treated with CC14 alone. Biochemical and histological results confirm the hepatoprotective effect of aqueous extract of SC.

关键词： Saussurea costus CC14 hepatotoxi^ity extract liv-52 histopathology biochemistry.

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