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A novel translabial platform utilizing bioexcipients from litchi chinesis for the delivery of rosiglitazone maleate

Acta Pharmaceutica Sinica B 2013年第6期3卷 408-415页

作者： N.V.Satheesh Madhav Abhay Pratap Yadav Novel Drug Delivery Research Laboratory Faculty of PharmacyDehradun Institute of Technology UniversityDehradunUttarakhand 248009India

The aim of this study was to formulate drug-loaded bio-lipstrips using novel bioexcipients isolated from the fruit pulp of litchi chinesis(biomaterial L)and to explore the potentiality of lip skin as a novel translabial drug delivery *** biomaterial,prepared by a simplified economical process and purified by hot dialysis,was subjected to various physicochemical evaluations along with spectral analysis including UV,FT-IR,Mass and ^(1)H *** lipstrip formulated with the novel bioexcipients was screened for its functional properties,including filmability using a film-casting method,and bio/mucoadhesitivity using a shear-stress method,the Park and Robinson method and a rotating cylinder ***-loaded bio-lipstrips were formulated by using biomaterial L as a strip former and dextrose as a *** formulated strips were subjected to various evaluations,including thickness,folding endurance,in-vitro release and in-vivo *** release of rosiglitazone maleate was maintained over 24 h,which was confirmed in in-vitro and in-vivo release *** results reveal that this biopolymer possesses promising stripability as well as *** formulated bio-lipstrips are feasible for delivering rosiglitazone maleate by translabial administration.

关键词： Translabial Rosiglitazone litchi chinesis Strip Bio-polymer

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