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liqi huoxue dripping pill protects against myocardial ischemia-reperfusion injury via the PI3K/Akt/GSK-3β signaling pathway in rats

引用

Traditional Medicine Research 2023年第4期8卷 29-37页

作者： Jia-Yi Zhan Yao Zhang Xie Zhong Han Mao Xiang-Yun Chen Yao-Feng Li School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025China

Background:liqi huoxue dripping pill(LQHXDP),a traditional Chinese drug for coronary heart disease,has a protective effect on the heart of rats with myocardial ischemia-reperfusion injury(MIRI)in previous studies;however,its mechanism of action remains *** purpose of this study was to investigate the protective mechanism of LQHXDP on MIRI in rats and its relationship with the PI3K/Akt signaling ***:In this study,Sprague-Dawley rats were pre-infused with LQHXDP(175 mg/kg/d)for 10 ***3K inhibitor LY294002(0.3 mg/kg)was intravenously injected 15 minutes before *** rat model of MIRI was established by ligating the left anterior descending coronary ***,cardiac hemodynamics,serum myocardial injury markers,inflammatory factors,myocardial infarct size,antioxidant indexes,myocardial histopathology,and phosphorylation levels of key proteins of PI3K/Akt signaling pathway were assessed in ***:LQHXDP was found to improve cardiac hemodynamic indexes,reduce serum creatine kinase MB isoenzyme activity and cardiac troponin and heart-type fatty acid binding protein levels,lower serum interleukin-1 beta,interleukin-6 and tumour necrosis factorαlevels,reduce the myocardial infarct size and enhance the antioxidant capacity of myocardial tissue in MIRI *** analysis revealed that LQHXDP attenuated the extent of myocardial injury and protected mitochondria from damage in MIRI *** analysis revealed that LQHXDP increased the expression levels of p-Akt and p-GSK-3βin MIRI rat ***3K inhibitor LY294002 could impair these effects of ***:LQHXDP attenuated myocardial injury,attenuated oxidative stress injury and reduced inflammatory response in MIRI rats,and its protective effects were mediated by activating of PI3K/Akt/GSK-3βsignaling pathway.

关键词： liqi huoxue dripping pill myocardial ischemia-reperfusion injury myocardial injury PI3K/Akt/GSK-3βsignaling pathway

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