检索结果-南通市图书馆

Caspofungin versus liposomal amphotericin b for treatment of invasive fungal infections or febrile neutropenia

Chinese Medical Journal 2014年第4期127卷 753-757页

作者： Zhang Jinyu Gong Yizhen Wang Ke Kong Jinliang Chen Yiqiang Institute of Respiratory Disease the First Affiliated Hospital Guangxi Medical University NanningGuangxi 530021 China Department of Evidence-based Medicine the First Affiliated Hospital Guangxi Medical University Nanning Guangxi 530021 China

background Nowadays,there are published trials in regards to the comparison of caspofungin with liposomal amphotericin b （L-Amb）.However,these studies have a modest sample size and convey inconclusive *** aim of this study was to review the efficacy and safety of caspofungin for the treatment of invasive fungal infections （IFIs）,compared with *** Electronic databases （up to July 31,2013） PubMed and Embase databases,the Cochrane Library,and Google Scholar were searched to identify relevant trials of caspofungin and *** of efficacy and adverse outcomes were performed by relative risks （RRs） and 95% confidence intervals （C/s）.Heterogeneity was assessed by x2-test and the/*** Three trials were included in this meta-analysis with 1249 modified intention-to-treat （MITT） *** results showed that caspofungin produced equal efficacy in favorable overall response （RR=1.02,95% Cl 0.88-1.18; P=0.81） and mortality rate （RR=1.53,95% Cl 0.38-6.27,P=0.55）,safer in clinical adverse events （RR=0.20,95% Cl 0.08-0.54; P=0.001）,laboratory adverse events （RR=0.69,95% Cl 0.57-0.84; P=0.0002）,and discontinuation rate （RR=0.26,95% Cl 0.08-0.83,P=0.02）,compared with L-Amb in the treatment of patients with *** based on the results of this meta-analysis,it would appear that caspofungin was measured to have equal efficacy in clinical outcomes and safer in terms of adverse events.

关键词： caspofungin liposomal amphotericin b meta-analysis treatment invasive fungal infections febrile neutropenia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The first report of treatment of liver abscess due to Candida albicans with intra-abscess and intravenous administration of liposomal amphotericin b (Amphotec)

引用

Journal of Medical Colleges of PLA(China) 2005年第3期20卷 191-192页

作者：廖万清姚志荣温海徐红杨松林刘兴华谭卫萍 Departent of Dermatology Changzheng Hospital Second Military Medical University Department of Plastic Surgery Changzheng Hospital Second Military Medical University Deparment of Ultrasonic Medicine Changzheng Hospital Second Military Medical University

Increasing reports on application and safety of liposomal amphotericin b (Amphotec) in the treatment of deep fungal infections have been described recently. This is the first report that a case of liver abscess due to Candida albicans was completely cured with intra-abscess and intravenous administration of liposomal amphotericin b without recurrence in three-year follow-up period.

关键词： liposomal amphotericin b Candida albicans liver abscess

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy and Safety Assessment of Antifungal Sequential Therapy from Micafungin to liposomal amphotericin b for Antibiotics-Refractory Febrile Neutropenia in Patients with Hematologic Malignancies

引用

Advances in Microbiology 2023年第6期13卷 315-322页

作者： Kazunori Nakase Koji Oka Keiki Kawakami Tetsuya Tsukada Shigehisa Tamaki Atsushi Fujieda Department of Personalized Cancer Immunotherapy Mie University Graduate School of Medicine Tsu Japan Department of Hematology and Oncology Mie University Hospital Tsu Japan Department of Internal Medicine Suzuka Kaisei Hospital Kameyama Japan Department of Internal Medicine Suzuka Chuo Hospital Suzuka Japan Department of Internal Medicine Takeuchi Hospital Tsu Japan Department of Internal Medicine Ise Red Cross Hospital Ise Japan

Invasive fungal infections are a major challenging problem in the management of febrile neutropenia (FN) in patients with hematologic malignancies. liposomal amphotericin b (L-Amb) or micafungin (MCFG) has been widely used as a first-line empirical antifungal therapy for suspected fungal infection in such patients. However, there are several issues in patients receiving these agents: drug related toxicities for L-Amb and breakthrough fungal infections for MCFG. In order to make the best use of these 2 agents, we conducted a prospective study of sequential therapy from MCFG to L-Amb, and evaluated the efficacy and safety of this strategy in FN patients with hematologic malignancies. A total of 18 patients were enrolled, and 11 patients who fulfilled the protocol defined criteria were evaluated. Underlying diseases consisted of acute leukemia (n = 9), non-Hodgkin lymphoma (n = 1), and myelodysplastic syndrome (n = 1). Treatment success was achieved in 8 patients (72.7%). Drug-related adverse events occurred in 8 patients (72.7%). All of those adverse events except one case were below grade 2. Three patients required discontinuation of L-Amb. Although our empirical antifungal sequential therapy seems to be encouraging for antibiotics-refractory FN in patients with hematologic malignancies, further investigation in large-scale studies is warranted.

关键词： Empirical Antifungal Therapy Micafungin liposomal amphotericin b Febrile Neutropenia Hematologic Malignancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Disseminated Fusarium bloodstream infection in a child with acute myeloid leukemia:A case report

引用

World Journal of Clinical Cases 2021年第21期9卷 6049-6055页

作者： Jun-Jie Ning Xue-Mei Li Sheng-Qiu Li Department of PICU First People's Hospital of Zigong CityZigong 643000Sichuan ProvinceChina

bACKGROUND Disseminated Fusarium is rare in healthy *** with hematological tumors may have secondary fungal infections,including Fusarium infections,which are due to tumor bone marrow infiltration or prolonged bone marrow suppression after *** of the lack of typical clinical manifestations and effective antifungal drugs,early diagnosis and treatment of the disease are difficult,and the prognosis is *** SUMMARY The patient in this case was a 13-year-old female child with rash and fever as the first *** had the characteristics of the four stages of skin that are typical of Fusarium *** was diagnosed with disseminated Fusarium infection through skin biopsy and blood culture and diagnosed with Fusarium solani infection based on the morphological characteristics of the blood *** treatment with liposome amphotericin b combined with voriconazole,the child *** This case highlights that for children with secondary agranulocytosis after receiving chemotherapy for hematological malignancies,once typical abnormal skin damage is found,the possibility of Fusarium infection should be considered,and voriconazole alone or in combination with polyenes may be the most effective anti-Fusarium *** b,the traditional drug of disseminated Fusarium disease,has a high mortality rate,and it is not recommended to use it *** neutrophil counts are essential for the treatment of disseminated Fusarium bloodstream infection.

关键词： Fusarium liposomal amphotericin b Voriconazole Acute myeloid leukemia Agranulocytosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of bronchoscopy-guided treatment and oral posaconazole to treat pulmonary mucormycosis:a case report and literature review

引用

Infectious Diseases Research 2021年第4期2卷 1-5页

作者： Peng-Cheng Zhou Wei Yu Department of Respiratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan provinceChina Clinical Medical School Chengdu University of Traditional Chinese MedicineChengduSichuan provinceChina

background:Pulmonary mucormycosis(PM)is rare condition,which is difficult to diagnose and has a high mortality ***,there is a lack of effective drugs,with few side effects,to treat *** have been a few reports on the use of bronchoscopy and posaconazole for the treatment of adult ***:A man with diabetes mellitus developed diabetic ketoacidosis and subsequently developed repeated cough,hemoptysis,and *** was diagnosed with pneumonia and was treated with antibiotics in a local ***,his condition *** admission to our hospital,chest computed tomography(CT)showed bilateral pneumonia and cavities in the left upper lobe that were significantly worse than those seen *** revealed swelling of the left bronchial mucosa and yellow necrosis adhering to the *** of transbronchial lung biopsy specimens revealed PM pneumonia,characterized by numerous mucormycelia,spores,and neutrophils between necrotic ***:Following diagnosis,liposomal amphotericin b was administered intravenously,and although the symptoms improved significantly,side effects caused the patient to discontinue taking the *** alternative regimen,including oral posaconazole and local injection of amphotericin b was administered via ***,the patient did not experience any discomfort and chest CT showed complete resolution of the consolidation and the lung ***:bronchoscopy can play an important role in the diagnosis and treatment of *** combination of oral posaconazole and bronchoscopy-guided anti-infective therapy is a novel and effective way to treat PM for patient cannot tolerate liposomal amphotericin b.

关键词： Pulmonary mucormycosis bronchoscopy posaconazole liposomal amphotericin b

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：