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Orbital liposarcoma: a retrospective, single-center study of thirteen patients

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1293-1298页

作者： Ning Gao Xin Ge Cheng Pei Jian-Min Ma Ya-Guang Hu Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To explore the clinical and pathological characteristics of thirteen patients with orbital liposarcoma.METHODS:The clinical history data of thirteen patients diagnosed as orbital liposarcoma at Beijing Tongren Hospital,from 2006 to 2021 were collected and analyzed.The data includes age,gender,affected orbital side,course of disease,status of disease(primary or recurrent),clinical manifestations,preoperative visual acuity,operative treatment,the relations between liposarcoma and surrounding tissue,longest diameter of liposarcoma,histological subtype,immunohistochemical indicators,follow-up treatment and prognosis.RESULTS:The initial symptoms are diverse.Proptosis is the most frequent chief complaint and the others included vision loss,epiphora,diplopia,and eyelid palpable mass.Results of imaging examination[computed tomography(CT)or magnetic resonance imaging(MRI)]showed orbital mass.In terms of treatment,10 patients received tumor resection,and the mean longest diameter of the tumor was 3.39±1.36 cm.The other 3 patients had optic nerve invaded,so they received orbital exenteration.Pathological examination results confirmed the diagnose of liposarcoma for 13 patients.Six patients displayed as myxoid type,and three patients in each type of dedifferentiated and welldifferentiated type.One patient was verified as pleomorphic,which was a rare type of liposarcoma.All of the patients showed Vimentin positive,and most showed CD34 and S-100 positive.Besides,four patients showed smooth muscle actin positive.All thirteen patients were alive.CONCLUSION:Orbital liposarcoma is a rare disease and it has no specific clinical manifestation.The diagnosis of liposarcoma should be considered when proptosis and orbital mass occurred in orbit.It is recommended to perform pathological examination to achieve early detection and early treatment.

关键词： liposarcoma orbital tumor orbital mass proptosis

Primary duodenal dedifferentiated liposarcoma:A case report and literature review

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World Journal of Clinical Cases 2022年第6期10卷 2007-2014页

作者： Nah Ihm Kim Ji Shin Lee Chan Choi Jong Hee Nam Yoo Duk Choi Hee Joon Kim Sung Sun Kim Department of Pathology Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Dedifferentiated liposarcoma(DDLPS)is an extremely rare neoplasm that exhibits various morphologies.The tumor is characterized by immunoreactivity to MDM2 and CDK4 and can be confirmed by detecting MDM2 amplification via fluorescence in situ hybridization(FISH).Herein,we report an unusual case of DDLPS arising from the duodenum.CASE SUMMARY A 64-year-old man presented with repeated abdominal pain and weight loss.Radiologic studies revealed a mass of the duodenum involving the pancreas.The patient was treated with pylorus-preserving pancreaticoduodenectomy.Histologically,the tumor showed a high-grade sarcoma.Immunohistochemistry demonstrated that the tumor cells were positive for MDM2 and CDK4 expression.MDM2 amplification was detected via FISH,leading to the final diagnosis of DDLPS.Following surgery,the patient was treated in the intensive care unit due to peritonitis,and died 60 d after surgery.CONCLUSION To the best of the authors’knowledge,this is the first case of primary duodenal DDLPS in Korea and the third case in the English-language literature.Care must be taken not to misdiagnose DDLPS as another high-grade tumor.liposarcoma should be in the differential diagnosis list.

关键词： liposarcoma Primary Small bowel Duodenum Immunohistochemistry Case report

liposarcoma of the stomach: Report of two cases and review of the literature

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World Journal of Gastroenterology 2018年第25期24卷 2776-2784页

作者： Wen-Zhe Kang Li-Yan Xue Gui-Qi Wang Fu-Hai Ma Xiao-Long Feng Lei Guo Yang Li Wei-Kun Li Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscope National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.

关键词： Pathology Signs and symptoms Diagnosis liposarcoma Therapeutics

Prognostic Factors Predicting the Postoperative Survival Period Following Treatment for Primary Retroperitoneal liposarcoma

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Chinese Medical Journal 2015年第1期128卷 85-90页

作者： Xudong Zhao Peiyu Li Xiaohui Huang Lin Chen Na Liu Yaoguang She Department of General Surgery General Hospital of Chinese People's Liberation Army Beijing 100853 China

Background：liposarcomas,which represent 20% of all adult sarcomas,are the most common histological type of malignant soft tissue tumors.The aim of this study was to define the prognostic factors that predict the postoperative survival period for patients with primary retroperitoneal liposarcoma.Methods：The clinical data and prognoses of 71 patients with primary retroperitoneal liposarcoma who were treated in the General Hospital of the People＇s Liberation Army of China between January 1,2000 and December 31,2007 were retrospectively reviewed and analyzed.Results：The primary tumor from each patient was resected; 54.9% （39/71） were deemed R0 resections,31.0% （22/71） were R1 resections and 14.1% （10/7 l） were deemed R2 resections （palliative operations）.The median follow up was 68 months （range：1-160 months）.Of the patients who received an R1 or R2 resection of their primary tumor,96.7% （59/61） had tumor recurrence.The 1-year,3-year,and 5-year recurrence-free rates were 77.0%,29.8% and 19.7%,respectively.As of April 2013,53 of the 71 patients had died from tumor recurrence.The overall l-year,3-year,5-year,and 10-year survival rates were 88.7%,76.1%,61.7%,and 30.4%,respectively.The factors that were significantly associated with prognosis in the univariate analysis were age （as a categorical variable）（P =0.006）,modus operandi （P =0.000）,histologic subtype （P =0.000）,tumor grade （P =0.000）,ascites （P =0.000）,postoperative metastasis （P =0.000） and adjuvant therapy （P =0.030）.However,in the multivariate analysis,the modus operandi （P =0.000）,tumor grade （P =0.006）,ascites （P =0.027）,postoperative metastasis （P =0.023） and age （as a categorical variable）（P =0.002） were the only significant predictors of survival.Conclusions：Complete resection remains the most effective method for treating liposarcoma.High grade,old age （≥60 years old）,postoperative metastasis,and ascites predict poor prognoses.

关键词： General Surgery liposarcoma Retroperitoneal Neoplasms Survival Therapeutics

Correlation of different imaging modalities in pre-surgical evaluation of pericardial metastasis of liposarcoma

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Chinese Medical Journal 2012年第20期125卷 3752-3754页

作者： Zeljko Z Markovic Ana Mladenovic Marko Banovic Branislava Ivanovic Radiology ClinicUniversity Clinical Center of Serbia Pasterova 2BelgradeSerbia Cardiology Clinic University Clinical Center of SerbiaPasterova 2BelgradeSerbia

A patient presented with a large pericardial tumor of uncertain etiology. Five years earlier, she had been treated for myxoid liposarcoma of the thigh. For pre-surgical evaluation, conventional radiography, positron emission tomography/computed tomography （PET/CT）, magnetic resonance imaging （MRI）, CT of the heart, transthoracic echocardiography （TTE） and transesophageal echocardiography （TEE） were performed. The final histopathologic diagnosis was metastatic liposarcoma. Each of the imaging modalities used had advantages and disadvantages, and their coordination was necessary for optimal evaluation.

关键词： liposarcoma pericardial metastasis,＂ imaging modality

A giant primary myxoid liposarcoma of the posterior mediastinum

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Chinese Medical Journal 2010年第13期123卷 1818-1820页

作者： LIU Li-gang WEI Xiang PAN Tie-cheng Department of Cardiothoracic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Primary mediastinal liposarcoma is an uncommon neoplasm of intrathoracic origin. A case of a giant primary posterior mediastinal liposarcoma, mimicking a benign lipomatous lesion in shape and biological behavior and b... 详细信息

关键词： mediastinal neoplasm liposarcoma radiology surgery

Devascularization of the superior mesenteric vein without reconstruction during surgery for retroperitoneal liposarcoma: A case report and review of literature

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World Journal of Gastroenterology 2018年第22期24卷 2406-2412页

作者： Run-Chen Miao Yong Wan Xiao-Gang Zhang Xing Zhang Yan Deng Chang Liu Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University

A 61-year-old female patient with chronic hepatitis B virus infection was diagnosed with liposarcoma in a community hospital. Fine needle aspiration biopsy confirmed the diagnosis of well-differentiated liposarcoma. Abdominal computed tomographic angiography(CTA) showed that the mass adhered to and constricted the main trunk and branch of the superior mesenteric vein(SMV), especially the ileocolic vein, and collateral circulation was observed during the vascular reconstruction scan. The abdominal liposarcoma was resected. Because of the collateral circulation, devascularization of the SMV was attempted, and we resected the eroded SMV. The condition of the blood vessels was evaluated 20 d after surgery using CTA, which showed that the SMV had disappeared. Significant improvements in SMV collateral circulation and the inferior mesenteric vein were observed after vascular reconstruction. The patient had an uneventful postoperative course except for transient gastroplegia. Twenty months after surgery, the patient had a recurrence of liposarcoma. She underwent tumor resection to remove the distal small intestine and right hemicolon. We learned that(1) direct devascularization of the main SMV trunkwithout a vein graft is possible. The presence of collateralcirculation can increase the success rate of patientsundergoing radical surgery and prevent the occurrence ofserious postoperative complications. In addition,(2) thiscase demonstrated the clinical value of 3 D reconstruction.

关键词： Superior mesenteric vein Retroperitoneal liposarcoma Surgery

Well-differentiated liposarcoma of esophagus

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Chinese Medical Journal 2006年第5期119卷 438-440页

作者： YANG Bin SHI Pei-zhi LI Xiao XU Ru-jun Department of Radiology Hangzhou First People＇s HospitalHangzhou 310006China Department of Pathology Hangzhou First People＇s HospitalHangzhou 310006China

Gastrointestinal liposarcoma is rare, and the esophagus is the. least common location at which this kind of liposarcoma reported a patient with a may occur. We well-differentiated liposarcoma of esophagus, and discus... 详细信息

关键词： liposarcoma esophagus tomography X-ray computed magnetic reasonance imaging

Huge primary dedifferentiated pancreatic liposarcoma mimicking carcinosarcoma in a young female: A case report

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World Journal of Clinical Cases 2019年第11期7卷 1344-1350页

作者： Zhe Liu Wu-Feng Fan Gui-Chen Li Jin Long Yuan-Hong Xu Gang Ma Department of Pancreatic-Biliary Surgery First Hospital of China Medical University

BACKGROUND Pancreatic liposarcoma is a rare tumor. According to a literature review, the patient described in this study is the seventh case of pancreatic liposarcoma reported in the English literature and the third case of dedifferentiated liposarcoma. Furthermore, this case had the largest primary tumor volume, and a primary pancreatic liposarcoma was diagnosed based on sufficient evidence. CASE SUMMARY We here report a rare case of a 28-year-old female with a huge dedifferentiated liposarcoma in the pancreatic tail. In June 2015, the patient underwent distal pancreatectomy with splenectomy. During the operation, a huge liposarcoma of approximately 28.0 cm × 19.0 cm × 8.0 cm was found, which had a yellow and white fish-like incisal surface. Based on both pathology and MDM2 gene amplification, the tumor was diagnosed as a dedifferentiated liposarcoma. The patient was treated with surgery but declined postoperative chemotherapy. She was well at the 26-mo follow-up, and no relapse was observed. CONCLUSION Pancreatic liposarcoma has a low incidence. Chemotherapy should be included in the treatment regimens. Complete resection is the only effective treatment.

关键词： Pancreatic liposarcoma Huge tumor Distal pancreatectomy and splenectomy Chemotherapy Case report