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Characterization of lipid-based nanomedicines at the single-particle level

Fundamental Research 2023年第4期3卷 488-504页

作者： Chaoxiang Chen Chen Chen Yurou Li Ruilan Gu Xiaomei Yan Department of Chemical Biology MOE Key Laboratory of Spectrochemical Analysis&InstrumentationKey Laboratory for Chemical Biology of Fujian ProvinceCollaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005China Department of Biological Engineering College of Ocean Food and Biological EngineeringJimei UniversityXiamenFujian 361021China

lipid-based nanomedicines(LBNMs),including liposomes,lipid nanoparticles(LNPs)and extracellular vesicles(EVs),are recognized as one of the most clinically acceptable nano-formulations.However,the bench-to-bedside translation efficiency is far from satisfactory,mainly due to the lack of in-depth understanding of their physical and biochemical attributes at the single-particle level.In this review,we first give a brief introduction of LBNMs,highlighting some milestones and related scientific and clinical achievements in the past several decades,as well as the grand challenges in the characterization of LBNMs.Next,we present an overview of each category of LB-NMs as well as the core properties that largely dictate their biological characteristics and clinical performance,such as size distribution,particle concentration,morphology,drug encapsulation and surface properties.Then,the recent applications of several analytical techniques including electron microscopy,atomic force microscopy,fluorescence microscopy,Raman microscopy,nanoparticle tracking analysis,tunable resistive pulse sensing and flow cytometry on the single-particle characterization of LBNMs are thoroughly discussed.Particularly,the com-parative advantages of the newly developed nano-flow cytometry that enables quantitative analysis of both the physical and biochemical characteristics of LBNMs smaller than 40 nm with high throughput and statistical ro-bustness are emphasized.The overall aim of this review article is to illustrate the importance,challenges and achievements associated with single-particle characterization of LBNMs.

关键词： lipid-based nanomedicines Liposomes lipid nanoparticles Extracellular vesicles Single-particle analysis Nano-flow cytometry Drug encapsulation Surface modification

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