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lipid droplets in the nervous system:involvement in cell metabolic homeostasis

Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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lipid droplets as metabolic determinants for stemness and chemoresistance in cancer

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World Journal of Stem Cells 2021年第9期13卷 1307-1317页

作者： Alba Royo-Garcia Sarah Courtois Beatriz Parejo-Alonso Pilar Espiau-Romera Patricia Sancho Hospital Universitario Miguel Servet IIS AragónZaragoza 50009Spain

Previously regarded as simple fat storage particles,new evidence suggests thatlipid droplets(LDs)are dynamic and functional organelles involved in keycellular processes such as membrane biosynthesis,lipid metabolism,cellsignalling and ***,an increased LD content is one of the mostapparent features resulting from lipid metabolism reprogramming necessary tosupport the basic functions of cancer *** have been associated to differentcellular processes involved in cancer progression and aggressiveness,such astumorigenicity,invasion and metastasis,as well as ***,all of these processes are controlled by a subpopulation of highly aggressivetumoral cells named cancer stem cells(CSCs),suggesting that LDs may befundamental elements for stemness in *** the key role of CSCs onchemoresistance and disease relapse,main factors of therapy failure,the design ofnovel therapeutic approaches targeting these cells may be the only chance forlong-term survival in cancer *** this sense,their biology and functionalproperties render LDs excellent candidates for target discovery and design ofcombined therapeutic *** this review,we summarise the currentknowledge identifying LDs and CSCs as main contributors to cancer aggressiveness,metastasis and chemoresistance.

关键词： lipids lipid droplets lipid metabolism Stemness Cancer stem cells Chemoresistance

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Localization of Seed Oil Body Proteins in Tobacco Protoplasts Reveals Specific Mechanisms of Protein Targeting to Leaf lipid droplets

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Journal of Integrative Plant Biology 2011年第11期53卷 858-868页

作者： Stefania De Domenico Stefania Bonsegna Marcello Salvatore Lenucci Palmiro Poltronieri Gian Pietro Di Sansebastiano Angelo Santino Institute of Sciences of Food Production C.N.R. Unit of Lecce via Monteroni Lecce 73100 Italy Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali Universita` del Salento via Monteroni Lecce 73100 Italy

Oleosin, caleosin and steroleosin are normally expressed in developing seed cells and are targeted to oil bodies. In the present work, the cDNA of each gene tagged with fluorescent proteins was transiently expressed into tobacco protoplasts and the fluorescent patterns observed by confocal laser scanning microscopy. Our results indicated clear differences in the endocellular localization of the three proteins. Oleosin and caleosin both share a common structure consisting of a central hydrophobic domain flanked by two hydrophilic domains and were correctly targeted to lipid droplets （LD）, whereas steroleosin, characterized by an N-terminal oil body anchoring domain, was mainly retained in the endoplasmic reticulum （ER）. Protoplast fractionation on sucrose gradients indicated that both oleosin and caleosin- green fluorescent protein （GFP） peaked at different fractions than where steroleosin-GFP or the ER marker binding immunoglobulin protein （BiP）, were recovered. Chemical analysis confirmed the presence of triacylglycerols in one of the fractions where oleosin-GFP was recovered. Finally, only oleosin- and caleosin-GFP were able to reconstitute artificial oil bodies in the presence of triacylglycerols and phospholipids. Taken together, our results pointed out for the first time that leaf LDs can be separated by the ER and both oleosin or caleosin are selectively targeted due to the existence of selective mechanisms controlling protein association with these organelles.

关键词： artificial oil bodies caleosin endoplasmic reticulum lipid droplets oleosin protein sorting steroleosin.

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Hydrogen-bond locked purine chromophores with high photostability for lipid droplets imaging in cells and tissues

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Chinese Chemical Letters 2023年第4期34卷 300-303页

作者： Jinlin Zhou Kun Li Lei Shi Hong Zhang Haoyuan Wang Yimin Shan Shanyong Chen Xiao-Qi Yu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610064China Department of Chemistry Xihua UniversityChengdu 610039China

Recently, hydrogen-bonding has attracted extensive attention in the design of chromophores. Here, a new class of hydrogen-bond locked purine chromophores(HOPs) were reported by introducing a hydroxyphenyl group into the C(6) position of purine. The intramolecular hydrogen bond plays a dominant role to light up these probes. As a bonus, HOPs show high photostability. Moreover, HOPs exhibit remarkable capability for the specific lipid droplets imaging in living cells with excellent biocompatibility and are also potential for diagnosing fatty liver diseases. These results bring important new insights into the photophysics of the purine-based chromophores and provide a new scaffold with high photostability for bioimaging.

关键词： Fluorescent probe Purine Hydrogen bond lipid droplets Fatty liver

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Light-up lipid droplets for the visualization of lipophagy and atherosclerosis by coumarin-derived bioprobe

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Chinese Chemical Letters 2021年第8期32卷 2385-2389页

作者： Jinrong Zheng Shuheng Qin Lijuan Gui Hua Li Lixue Fan Yifei Yang Haiyan Chen Hui Xu Zhenwei Yuan Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China Department of Food Quality and Safety College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and ProcessingNanjing University of Finance and EconomicsNanjing 210023China

lipid droplets(LDs) are intracellular lipid-metabolism organelles that involved in many physiological processes,metabolic disorders as well as diseases such as ***,the specific probes that can visually locate abnormal LDs-rich tissues and track LDs-associated behavior to the naked eye with adequate biosafety still are ***,we develop a new design strategy of LDs-targeted probe based on the solvatochromism of coumarin *** results revealed that the emission wavelength of coumarin fluorophores gradually red shift in different solvents with increasing polarity,while absorption wavelength almost *** a result,the enlarged stokes shift of coumarin was emerged from oil to ***,properly reducing water solubility and adding electronic donor at the structure of coumarins can enlarge this type of *** discovery was utilized to develop suitable probe for the image of LDs and LDs-rich tissues with high resolution and ***,LDs-associated behavior was visible to the naked eye during the process of lipophagy and *** deem that the developed probe here offers a new possibility to accurately diagnosis and analyse LDs-related diseases in clinic and preclinical study.

关键词： lipid droplets Probe Lipophagy Atherosclerosis

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Effect of testicular capsulotomy on lipid droplets in the seminiferous tubules of rats

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Asian Journal of Andrology 2001年第2期3卷 121-124页

作者： Da-NianQIN MaryA.Lung DepartmentofPhysiology ShantouUniversitySchoolofMedicineShantou.515031China DepartrnentofPhysiology TheUniversityofHongKongHKSARChina

Aim: In order to reveal the histochemical alteration that might occur during the processes of the spermatogenic dis-ruption induced by testicular capsulotomy, the location and alteration of lipid droplets in the seminiferous tubules wereobserved in the present study. Methods: Osmium tetroxide was used to demonstrate the lipid droplets in the semi-niferous tubules of capsulotomized and sham-operated control testes. Results: In the seminiferous tubules of thesham-operated rat testes, many small lipid droplets were located close to the basement membrane of the seminiferoustubules. But for the capsulotomized testes, the lipid droplets in the seminiferous tubules had increased in size and num-ber, with many lipid droplets migrated towards the lumen of the tubules. Conclusion: The results indicated that aprogressive fatty degeneration occurred in the seminiferous tubules after testicular capsulotomy.

关键词： testis testicular capsulotomy lipid droplets

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A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death,inflammation and fatty liver tissue

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Chinese Chemical Letters 2024年第6期35卷 365-369页

作者： Xing Tian Di Wu Wanheng Wei Guifu Dai Zhanxian Li Benhua Wang Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Shenzhen Research Institute of Central South University Shenzhen 518057China

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of ***,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the *** is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the *** this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was *** not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.

关键词： lipid droplets AIE Polarity Ferroptosis Fatty liver

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Anti-lipid droplets accumulation effect of Annona montana(mountain soursop)leaves extract on differentiation of preadipocytes

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BIOCELL 2022年第3期46卷 567-578页

作者： IVY LEUNG MARIA-LUISA VEISAGA MARGARITA ESPINAL WEI ZHANG ROBERT BARNUM MANUEL ALEJANDRO BARBIERI Department of Biological Sciences Florida International UniversityMiami33199USA Biomolecular Sciences Institute Florida International UniversityMiami33199USA Fairchild Tropical Botanic Garden Coral Gables33156USA International Center of Tropical Botany Florida International UniversityMiami33199USA

The Annona genus is a member of Annonaceae,one of the largest families of plants across tropical and subtropical *** family has been used in several ethnomedicinal practices to treat a multitude of human ***,the molecular mechanism underlying its effect on the lipid droplet formation and on the expression of adipogenic markers of this plant remain to be *** this study,we examined whether the extracts from the aerial part of Annona montana affect in vitro differentiation of *** our investigations,both mouse embryo fibroblast 3T3-L1 and normal human primary subcutaneous preadipocytes were incubated with Annona montana extracts(-and its subfractions-)and then analyzed on preadipocyte differentiation,lipid content,lipid droplet size and number,the expression of adipogenic-specific transcriptional factors,as well as cell *** our examinations,we found the Annona montana ethyl acetate extract to exhibit a potent inhibitory effect on adipogenesis,without affecting cell survival,in a dose-dependent *** inhibitory effects included a significant decrease in the accumulation of lipid content by both a dramatic reduction of size and number of lipid *** extract strongly attenuated the expression of PPARγand *** also inhibited the expression of CEBPα,FAS,and Akt without influencing Erk1/2 *** findings suggest that specifically,the Annona montana ethyl acetate extract has a prominent inhibitory effect in cellular pathways of adipocyte differentiation by modulating specific gene expression,which is known to perform a pivotal role during adipogenesis.

关键词： Annona montana extracts Phytochemical analysis Adipogenesis lipid droplets Adipogenic-specific markers

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Manifesting viscosity changes in lipid droplets during iodined CT contrast media treatment by the real-time and in situ fluorescence imaging

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Chinese Chemical Letters 2023年第4期34卷 246-250页

作者： Ning Ding Xueliang Liu Aixia Meng Xiuxiu Zhao Gang Ma Weina Han Peng Dong Jianchun Li Jin Zhou School of Pharmacy School of Medical ImagingSchool of Basic Medical SciencesWeifang Key Laboratory of Pharmaceutical Chemical Biology for CancerWeifang Medical UniversityWeifang 261053China Weifang People’s Hospital Weifang 261000China

Computed tomography(CT) is one of the most commonly used non-invasive clinical imaging modalities to predict, diagnose and treat the disease. Iodinated contrast media(ICM) is a form of intravenous radiocontrast agent containing iodine, which enhances the visibility of hollow tissue structures in medical CT imaging. ICM may cause allergic reactions, contrast-induced nephropathy, hyperthyroidism and possibly metformin accumulation. It is significant to find out the risk factors, pathogenesis, diagnosis, prevention, and treatment of adverse reactions caused by ICM. Revealing the changes of the lipid droplets(LDs)viscosity in pathophysiological processes such as cancer and iodined contrast media induced adverse reaction is not only important for monitoring the occurrence and development of some pathophysiological processes but also vital for the deep insight of the biological effects of LDs in these pathophysiological processes. A lipid droplets targeted fluorescent probe DN-1 was devised to sense cellular viscosity alteration with high selectivity and sensitivity, which was applied to distinguish cancer cells and normal cells and reveal viscosity changes during iodined CT contrast media treatment.

关键词： Fluorescent probe Viscosity lipid droplets Iodined contrast media Distinguishment of cancer and normal cells

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lipid droplets imaging with three-photon microscopy

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Journal of Innovative Optical Health Sciences 2023年第4期16卷 20-28页

作者： Mubin He Hojeong Park Guangle Niu Qiming Xia Hequn Zhang Ben Zhong Tang Jun Qian State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research College of Optical Science and Engineering International Research Center for Advanced Photonics Zhejiang University Hangzhou 310058P.R.China Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Clear Water BayKowloonHong Kong 999077P.R.China Shenzhen Research Institute of Shandong University Shenzhen 518057 P.R.China Department of General Surgery Sir Run Run Shaw Hospital School of MedicineZhejiang University Hangzhou 310000P.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen Guangdong 518172P.R.China

lipid droplets(LDs)participate in many physiological processes,the abnormality of which will cause chronic diseases and pathologies such as diabetes and *** is crucial to monitor the distribution of LDs at high spatial resolution and large ***,we carried three-photon imaging of LDs in fat *** to the large three-photon absorption cross-section of the luminogen named NAP-CF_(3)(1:67×10^(-79) cm^(6) s^(2)),three-photon fluorescence fat liver imaging reached the largest depth of 80μ*** liver diagnosis was successfully carried out with excellent performance,providing great potential for LDs-associated pathologies research.

关键词： lipid droplets three-photon fluorescence microscopy fat liver,deep-tissue imaging

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