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lipid accumulation product: Reliable Marker for Cardiovascular Risk Detection?

Open Journal of Epidemiology 2021年第3期11卷 267-277页

作者： Lidiane Aparecida Vila Pires Ricardo José Tofano Sandra Maria Barbalho Claudia Rucco Penteado Detregiachi Marcelo Dib Bechara Viviane Alessandra Capelluppi Tofano Jesselina Francisco dos Santos Haber Eduardo Federighi Baisi Chagas Ana Maria Gonçalvez Milla Karina Quesada School of Medicine University of Marília (UNIMAR) Marília S&#227 o Paulo Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation University of Marilia (UNIMAR) S&#227 o Paulo Brazil Cardiology Unit of the UNIMAR Beneficent Hospital (HBU) Marilia S&#227 o Paulo Brazil Department of Biochemistry and Nutrition Faculty of Food Technology of Marília Marília S&#227 o Paulo Brazil CENID (Interdisciplinary Center on Diabetes)—UNIMAR—Marília S&#227 o Paulo Brazil

The lipid accumulation product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was ... 详细信息

The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was to verify the association of LAP with anthropometric, biochemical, visceral adiposity index and IR in adults and the elderly. This single cross-section center clinical study, with experimental, analytical, primary, and observational design, included 210 participants. Anthropometric (Body Mass Index (BMI), Waist Circumference (WC), and Neck Circumference (NC)), LAP, Visceral Adipose Index (VAI), and biochemical parameters (fasting glycemia, insulinemia (to calculate the Homa-IR index), total cholesterol, LDL-c, HDL-c, and triglycerides) were evaluated. The results showed that by separating the sample into three groups (adequate BMI and WC, adequate BMI and elevated WC, and elevated BMI and WC), the group with high BMI and WC showed a high value of LAP and VAI compared to the other groups, with a significant difference. Still, the data show a positive and significant correlation when relating the LAP with VAI, HOMA-IR, BMI, WC, NC, total cholesterol, triglycerides, and Diastolic Blood Pressure. It also showed an inversely proportional relationship when associating LAP with HDL-c (p

关键词： lipid accumulation product Obesity. Visceral Obesity Metabolic Syndrome Cardiovascular Risk

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Association between Chinese visceral adiposity index and risk of cardiometabolic multimorbidity in middle-aged and elderly Chinese population:Evidence from a national longitudinal study

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South China Journal of Cardiology 2024年第2期25卷 76-88,98页

作者：卢晓琪杨富丽曾平 Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical Sciences Department of Cardiology Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080GuangdongChina

Background There are several surrogate indicators of abdominal fat deposition,including tri-ponderal mass index(TMI),lipid accumulation product(LAP),and the Chinese visceral adiposity index(CVAI).In spite of this,it remains unclear whether these indices have a longitudinal relationship with the prevalence of cardiometabolic multimorbidity(CM),a pressing global health *** research investigated the association between CVAI and CM compared to other indicators of visceral *** 6638 participants(aged>45)from the China Health and Retirement Longitudinal Study(CHARLS)were analyzed for incident *** proportional models were adopted to explore whether the level of CVAI was correlated with the risk of ***'s concordance statistic(C-statistic)was applied to compare predictive *** and subgroup analyses were implemented for the steadiness of the *** Over 4 years,266(4.01%)participants developed CM.A 1-standard deviation(SD)increase in the levels of CVAI,body mass index(BMI),LAP,and TMI was associated with greater CM risk after adjusting for confounders[hazard ratios(HRs):2.20,95%confidence interval(CI):1.88-2.57,1.92(95%CI:1.55-2.38),1.20(95%CI:1.12-1.27),and 1.50(95%CI:1.35-1.66),respectively].CVAI outperformed other indices in predictive *** analysis revealed younger participants or those living alone were more prone to developing *** were potent after finishing all sensitivity *** The study highlighted a positive correlation between the level of CVAI and CM ***'s superior predictive performance positions it as a reliable indicator for identifying individuals at heightened CM risk.

关键词： China Health and Retirement Longitudinal Study(CHARLS) Cardiometabolic multimorbidity Chinese visceral adiposity index Abdominal obesity lipid accumulation product Tri-ponderal mass index

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