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Efficacy of Palmitoylethanolamide (Levagen+^TM) Compared to Ibuprofen for Reducing Headache Pain Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial

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Food and Nutrition Sciences 2022年第7期13卷 690-701页

作者： David Briskey Phillippa Ebelt Elizabeth Steels Silma Subah Nathasha Bogoda Amanda Rao School of Human Movement and Nutrition Sciences University of Queensland Brisbane Australia RDC Clinical Newstead Brisbane Australia Evidence Sciences New Farm Brisbane Australia Gencor Pacific Limited Discovery Bay Lantau Island New Territories Hong Kong China

Background: Palmitoylethanolamide (PEA) has shown promise as an analgesic for those with chronic pain pathologies. With recently increased bioavailability, PEA may also be a treatment for acute pain presentations such as tension-type headaches. Aim: To assess the efficacy of a bioavailable PEA formulation (Levagen+TM) for reducing the severity and duration of acute episodes of tension-type headaches when compared to a standard treatment, nonsteroidal anti-inflammatory drug (NSAID) (the comparator). Methods: The study was a double-blind, randomized, single site, comparator controlled clinical study, with the cohort consisting of otherwise healthy adults, aged between 18 and 71, who experienced regular tension-type headaches. 94 adults experiencing headaches were randomised to receive either PEA (n = 47) or Ibuprofen comparator (n = 47). Upon headache onset, participants consumed their allocated product, recorded pain levels using a visual analogue scale (VAS) and continued to log their pain scores at 30-minute intervals for up to 4-hours. Results: Eighty-six participants (44 active treatment and 42 comparator) recorded at least one headache with a total of 271 tension-type headaches recorded (120 active treatment and 151 comparator). Most headaches were reduced in both treatment arms by 2 hours and almost all by 4 hours;90% in the PEA group, and 97% in comparator group, p > 0.5. For moderate at onset headaches, the comparator group had a greater percentage of pain-free events at 2-hours. However, the time taken to resolve severe headaches was significantly lower in the PEA group than the comparator group (p Conclusions: These results place PEA as a potential treatment option for tension-type headaches.

关键词： PEA Palmitoylethanolamide Headaches Levagen lipisperse

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