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lipase inhibitory activity of Lagenaria siceraria fruit as a strategy to treat obesity

Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 285-290页

作者： Maria Maqsood Dildar Ahmed Iqra Atique Wajeeha Malik Department of Chemistry Forman Christian College(A Chartered University)LahorePakistan

Objective:To explore pancreatic lipase inhibitory activity under different extraction conditions in order to track the most potent ***:The methanolic extract and its fractions in solvents of increasing polarity,ether,chloroform,ethyl acetate,n-butanol and water,were made through cold *** in ethanol,ethyl acetate,acetone and chloroform were similarly *** extract was prepared through hot decoction method.A reported method was used to determine lipase inhibitory activity of extracts and fractions over wide ranges of ***:The extracts and fractions exhibited concentration dependent *** IC50(μg/mL)values of methanolic,ethanolic,chloroform,ethyl acetate,acetone,ethyl acetate(after washing with water)and aqueous decoction were 293.40,266.47,157.59,182.12,352.34,257.00,and 190.00,*** activity of chloroform,ethyl acetate and aqueous extracts were close to that of the drug orlistat(IC50 146μg/mL).Out of the fractions of the methanolic extract,the chloroform fraction was most active(IC50 189.6μg/mL).The order of inhibitory activity of the fractions was as follows:chloroform>ether>n-butanolic>aqueous>ethyl *** GC/MS analysis of the most active chloroform faction showed the presence of hexadecanoic acid,methyl hexadecanoate,isopropyl palmitate,methyl 9,12-octadecadienate,and methyl 9,12,***:The study suggests that Lagenaria siceraria has potential to inhibit pancreatic lipase activity,suppressing lipid digestion and thereby diminishing entry of lipids into the *** intake of aqueous decoction of the fruit may therefore be recommended for control of *** acids and their esters may play role as inhibitors of lipase.

关键词： Lagenaria siceraria Obesity lipase inhibitory activity Bottle gourd

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