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lingual flange protrusion:diagnostic marker for metastatic liver cancer

Journal of Traditional Chinese Medicine 2017年第6期37卷 782-788页

作者： Ma Yinlu Yang Xue Zhu Cuihong Cao Rui Wu Xiongzhi Tianjin Medical University Cancer Institute and Hospital Tianjin 300060China National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060ChinaZhong-Shan-Men In-PatientUniversity Cancer Institute China DepartmentTianjin Medical HospitalTianjin 300060 Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China

OBJECTIVE: To investigate the diagnostic significance of lingual flange protrusion for liver metastasis of patients with malignant ***: The data of 191 patients with malignant neoplasia were analyzed. All photos of patients' tongue image were recorded and lingual flange protrusion was the positive standard. χ~2 test for paired data and Kappa test were used to determine the diagnostic value of lingual flange protrusion for metastatic liver cancer. Mann-Whitney U test was used to compare the levels of liver serolog-ical markers. The area under receiver operating characteristic curve(ROC) and logistic regression model were used to analyze the predictive values of lingual flange protrusion, alkaline phosphatase(ALP), and lactate dehydrogenase(LDH) ***: Patients with lingual flange protrusion had a higher risk of liver metastasis than those without it(P lingual flange protrusion and traditional diagnostic criteria(P = 0.541). Kappa was 0.738(P lingual flange protrusion was significantly correlated with increased serum ALP and LDH levels(P lingual flange protrusion is better than ALP, LDH and the combination of ALP and LDH(P lingual flange protrusion and ALP,lingual flange protrusion and LDH, and lingual flange protrusion, ALP and LDH are not better than lingual flange protrusion alone(P > 0.05).CONCLUSION: lingual flange protrusion is a potential diagnostic marker for liver metastasis of patients with malignant neoplasia.

关键词： Liver neoplasms Tongue inspection lingual flange protrusion Alkaline phosphatase,Lactate dehydrogenases Gamma-glutamyltrans-ferase

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lingual Raynaud's phenomenon in a patient with mixed connective tissue disease

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Rheumatology & Autoimmunity 2021年第2期1卷 101-103页

作者： Emily L.Gilbert Division of Rheumatology Mayo ClinicJacksonvilleFloridaUSA

1|TEXT I present a case of lingual Raynaud's phenomenon(RP)in a 37-year-old Caucasian woman followed for mixed connective tissue disease(MCTD).During scheduled follow-up,she shared a selfie photograph demonstrating RP of the tongue with deep blue/violet *** was asymptomatic and had not recently eaten or drunk any cold or frozen food or *** tongue returned to normal coloration after about 2 min.

关键词： lingual Raynaud's mixed connective tissue disease

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Deep lingual arterial chemoembolization of tongue carcinoma with microcapsuled anticancer drug

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第10期8卷 704-708页

作者： HE Hong1, HUANG Jian-qi1, PING Fei-yun1, CHEN Guan-fu1, ZHANG Su-zhan2 (1Department of Stomatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) (2Cancer Institute, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) Department of Stomatology Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China.

Objective: Microcapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum. Methods: lingual artery cast specimens from cadavers were microscopically examined, and 78 patients with tongue cancer were recruited and treated with the deep lingual arterial embolization therapy. Results: Microcapsule embolism occurred approximately at the fifth or sixth level of the deep lingual artery branches. The five-year survival rate was 88.5% (69 out of 78), and the ten-year survival rate 52.6% (41 out of 78). Conclusion: The deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum is an effective therapy to treat carcinoma in mid-margin or mid-body of the tongue.

关键词： Tongue carcinoma Artery cast Arterial chemoembolization Deep lingual arterial embolization Anticancer drug Carboplatinum

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Morphology and Morphometry of the lingual Nerve in Relation to the Mandibular Third Molar

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Open Journal of Stomatology 2015年第1期5卷 6-11页

作者： Isaac Kipyator Bokindo Fawzia Butt Jameela Hassanali School of Dental Sciences University of Nairobi Nairobi Kenya Department of Human Anatomy University of Nairobi Nairobi Kenya Department of Oral & Maxillofacial Surgery University of Nairobi Nairobi Kenya

The position and branching of the lingual nerve (LN) in the mandibular third molar region were documented in 30 head hemi-sections (16: right and 14: left). In all the dissections, the LN was found below the level of the posterior alveolar crest (PAC). Branching was observed in 26 (86.7%) of the 30 specimen in which one branch was most frequently given per hemi-section. All branches were located superior to the main trunk of the LN. The mean vertical distance of the LN from the PAC was 10.3 ± 5.2 mm (range: 2.8 - 19.9 mm) whereas the mean antero-posterior distance was 7.1 ± 2.8 mm (range: 1.3 - 15.6 mm). The mean mandibular height from the PAC was 28.7 ± 4.0 mm (range: 23.3 - 40.7 mm). The vertical distance and mandibular height correlated positively giving a ratio of 1:2.7 between the two parameters. There was no significant difference between the two sides of the head. Position of the LN differed from previous studies suggesting that ethnicity may have a role in morphometry of the nerve. Use of different methodology may also contribute to this. Branches of the LN being closer to the PAC may be more prone to injury than the main trunk during surgical treatment.

关键词： lingual Nerve Branches Morphometry Morphology

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Macro-Micro-Anatomy of the lingual Artery

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Journal of Medical Colleges of PLA(China) 1990年第3期5卷 300-305页

作者：吴海燕何光篪陈尔瑜 Department of Anatomy Third Military Medical CollegeChongqing 630038

The macro-micro-anatomy of the lingual artery of 25 adult cadavers *** origin of the artery is rather concentrated and the greater cornu of thehyoid bone can be used as the *** entrance of the artery into the hyoglossusmuscle is almost constantly along the posterior border of the muscle,where the artery issuperficially located and easily to be exposed,and has a constant relationship with thevein and hypoglossal *** the lingual artery can be used as the artery of a recipientarea in case of tongue *** deep lingual artery has two types ofbranches;the short ones mainly supply the muscles of tongue while the long ones mainlysupply the mucosa by forming a submucosal *** the muscles of tongue,minutearterioles run tortuously along the muscular fibers with abundant anastomoses betweeneach other,but no anastomosis is found to cross over the rnidline of the ***-neath the mucosa,there is an arterial network spreading all over the whole tongue notlimited to one *** relationship of the arterial architecture to the structure and thefunctions of the tongue and its clinical significance were discussed.

关键词： lingual artery deep lingual artery sublinguat artery arterial architecture macro-micro-anatomy

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More Rapid Sleep Onset with lingual-Spray vs Oral-Tablet Delivery Zolpidem

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Pharmacology & Pharmacy 2019年第7期10卷 329-342页

作者： Robert B. Raffa Gerwin Westfield Univ Arizona College of Pharmacy Tucson AZ USA Temple Univ School of Pharmacy Philadelphia PA USA AytuBioScience Englewood CO USA

Insomnia and related sleep disorders (somnipathies) affect a large segment of the population, and result in a significant negative impact on quality of life and reduced or lost productivity. The speed of sleep onset is a critical characteristic of successful pharmacotherapeutic intervention for insomnia. Zolpidem, a non-benzodiazepine benzodiazepine receptor agonist (nBzRA) is widely used to treat insomnia. Although not itself a benzodiazepine (BZD), zolpidem has high binding affinity for the benzodiazepine receptor, which acts as a positive allosteric modulator of the GABAA receptor complex. It therefore increases the neuronal transmembrane influx of Cl- ions, thereby decreasing neuronal excitability and promoting sleep. In this four-way crossover, dose-ranging, multiple-treatment study, a lingual spray formulation of zolpidem was safe and well-tolerated and yielded more rapid pharmacokinetics (mean plasma concentration) and efficacy (visual analog scale and digit symbol substitution test) compared to oral tablets.

关键词： Zolpidem lingual Spray Pharmacokinetics Efficacy Safety/Tolerability AMBIEN

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Observation of the esophagus, pharynx and lingual root by gastrointestinal endoscopy with a percutaneous retrograde approach

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World Journal of Gastrointestinal Endoscopy 2010年第8期2卷 288-292页

作者： Michitaka Honda Yoshio Hori Yoshiki Shionoya Akira Nakada Toshihiko Sato Takeshi Kobayashi Hidenori Shimada Naoki Kida Tatsuo Nakamura Department of Bioartifical Organs Institute for Frontier Medical ScienceKyoto University

AIM:To evaluate the efficacy of retrograde observation of the esophagus, pharynx, larynx and lingual root. METHODS:With the beagle dog under anesthesia, the anterior wall of the stomach was fixed on the abdominal wall in a similar way to percutaneous endoscopic gastrostomy. The gastrointestinal scope was inserted via a 12 mm laparoscopic port for subsequent retrograde observation from stomach to the oral cavity. RESULTS:With this technique, direct observation of gastric cardia was possible without restriction. The cervical esophagus was dilated well, also allowing clear observation of the hypopharyngo-esophageal junction. If the tongue was manually pulled out forward, observation of the lingual root was ***: This procedure is easy and effective for pre-treatment evaluation of the feasibility of endoscopic resection in cases of superficial carcinoma of head and neck.

关键词： Mesopharynx lingual root Percutaneous endoscopic gastrostomy Gastrointestinal endoscopy Retrograde observation

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语言的裂变与文化的整合——瑶族多语文现象的时代特征

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贵州民族研究 1994年第3期14卷 131-141页

作者：徐新建贵州省社会科学院

一般而论,语言和文字是从理论上界定一个民族和在实际中凝聚一种文化的核心要素.语言和文字的改变,往往导致民族及其特定文化的变迁.如今,对于处在众多民族不断相遇、不同文化深入交往的现代世界来说,把握这一点,即把握民族语文与民族... 详细信息

一般而论,语言和文字是从理论上界定一个民族和在实际中凝聚一种文化的核心要素.语言和文字的改变,往往导致民族及其特定文化的变迁.如今,对于处在众多民族不断相遇、不同文化深入交往的现代世界来说,把握这一点,即把握民族语文与民族文化的特定关系,尤为重要.语言的裂变和文化的整合,是生活在强大民族包围之中和外来文化冲击之下。

关键词： lingual differeatiation cultural integration the Yao multi-lingualism

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Ablation of NTPDase2+ cells inhibits the formation of filiform papillae in tongue tip

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Animal Models and Experimental Medicine 2018年第2期1卷 143-151页

作者： Feng Li Bo-Wen Niu Meng-Min Zhu Department of Laboratory Animal Science Shanghai Public Health Clinical CenterFudan University

Background: lingual epithelia in the tongue tip are among the most rapidly regenerating tissues, but the mechanism of cell genesis in this tissue is still unknown. Previous study has suggested the existence of multiple stem cell pools in lingual epithelia and papillae. Like K14+ and Sox2+ cells, NTPDase2+ cells have characteristics of stem ***: We employed a system using doxycycline to conditionally ablate NTPDase2+ cells in lingual epithelia and papillae by regulated expression of the diphtheria toxin A(DTA) gene. Transgenic lines, which expressed the rtTA gene in NTPDase2+ cells, were produced by pronuclear injection of zygotes from C57 BL/6 mice using the BAC clone RP23-47 P18. The NTPDase2-rtTA transgenic mice were crossed with the TetO-DTA transgenic animals. The double transgenic mice were treated with doxycycline. Doxycycline(Dox) was diluted in 5% sucrose in water to a final concentration of 0.3-0.5 mg/mL and supplied as drinking ***: After 15 days of Dox induction, the expression of NTPDase2, Sox2 and K14 was ablated from lingual epithelia. DTA expression in NTPDase2+cells did not inhibit the turnover of GNAT3+ or PLCb2+ cells in taste buds,nor the expression of S100 b beneath lingual epithelia and papillae. After35 days ablation of NTPDase2+ cells, the basic structure of lingual epithelia and papillae remained intact. However, the ratio of cell to total tissue area was decreased in lingual epithelia and circumvallate(CV) papillae. DTA expression also inhibited the regeneration of filiform papillae on the dorsal surface of the tongue ***: These studies provide important insights into the understanding of dynamic equilibrium among the multiple stem cell populations present in the lingual epithelia and papillae.

关键词： cell ablation lingual epithelia NTPDase2 papillae tissue regeneration

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TREATMENT OF 32 CASES OF DYSMENORRHEA BY PUNCTURING HEGU AND SANYINJIAO ACUPOINTS

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Journal of Traditional Chinese Medicine 1990年第1期10卷 33-35页

作者：詹闯 Chenjiaqiao Hospital The Southern DistrictShanghai

Since 1986,the author has treated 32cases of dysmenorrhea by puncturing Hegu(LI 4) and Sanyinjiao(Sp 6)acupoints in theOPD of Acupuncture and Moxibustion,with satisfactory efficacy.A brief report isgiven as follows.

关键词： Acupuncture stasis satisfactory moxibustion brief minutes 寒湿凝滞型 retention lingual stimulation

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