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A finTRIM member 100 (FTR100) is unique to Otomorpha fish for constitutive regulation of IFN response

Water Biology and Security 2023年第2期2卷 80-90页

作者： Wen-Hao Guo Cheng Dan Xiu-Ying Gong Yi-Lin Li Hao-Yu Sun Zi-Ling Qu Li-Li An Xiang Zhao Jie Mei Jian-Fang Gui Yi-Bing Zhang State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan430072China University of Chinese Academy of Sciences Beijing10049China College of Fisheries Huazhong Agricultural UniversityWuhan430070China The Innovation Academy of Seed Design Chinese Academy of SciencesWuhan430072China

Vertebrate interferon(IFN)expression is fine-tuned in order to avoid excessive tissue injury under normal conditions and during virus ***(fish novel TRIM,FTR)proteins are reported to regulate the fish IFN ***,we identify a novel finTRIM gene from yellow catfish(Pelteobagrus fulvidraco),which is sequentially named PfFTR100 according to the nomenclature rule in ***-wide analyses reveal that FTR100 is unique to Otomorpha fish,with a single copy in spite of additional genome duplication in some fish *** that few of the 99 finTRIM genes identified in zebrafish are conserved in main fish branches and most,such as FTR100,are unique to distinct branches due to lineage-specific expansion of finTRIM genes,we develop a nomenclature for newly cloned finTRIM genes from different fish ***100 mRNA is not induced by virus infection,with a relatively high expression level comparable to that of cellular IFN and some IFN-stimulated genes(ISGs)in virally-infected ***,ectopically-expressed PfFTR100 protein is attenuated in virally-infected cells through the proteasomal-dependent *** of PfFTR100 promotes SVCV replication by downregulating the constitutive and inducible IFN response via a mechanism by which PfFTR100 targets IRF3 and IRF7 to attenuate their mRNA levels rather than their protein *** results indicate that yellow catfish FTR100 is essential for homeostatic regulation of fish tonic IFN response.

关键词： Constitutive expression FTR100 Homeostatic regulation lineage-specific expansion Tonic IFN response

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Identification of a novel Gig2 gene family specific to non-amniote vertebrates

Identification of a novel Gig2 gene family specific to non-a...

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中国水产学会鱼病专业委员会2013年学术研讨会

作者： Yi-Bing Zhang Ting-Kai Liu Jun Jiang Jun Shi Ying Liu Shun Li Jian-Fang Gui State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of Sciences

Gig2(grass carp reovirus(GCRV)-induced gene 2)is first identified as a novel fishinterferon(IFN)-stimulated gene(ISG).Overexpression of a zebrafish Gig2 gene can protectcultured fish cells from virus *** the present study,we identify a novel gene family that iscomprised of genes homologous to the previously characterized ***/GSS search and insilico cloning identify 190 Gig2 homologous genes in 51 vertebrate species ranged from lampreysto *** large-scale search of vertebrate and invertebrate genome databases indicatethat Gig2 gene family is specific to non-amniotes including lampreys,sharks/rays,ray-finnedfishes and *** analysis and synteny analysis reveal lineage-specificexpansion of Gig2 gene family and also provide valuable evidence for the fish-specific genomeduplication(FSGD)*** Gig2 family proteins exhibit no significant sequencesimilarity to any known proteins,a typical Gig2 protein appears to consist of two conserved parts:an N-terminus that bears very low homology to the catalytic domains of poly(ADP-ribose)polymerases(PARPs),and a novel C-terminal domain that is unique to this gene *** profiling of zebrafish Gig2 family genes shows that some duplicate pairs havediverged in function via acquisition of novel spatial and/or temporal expression under *** specificity of this gene family to non-amniotes might contribute to a large extent to distinctphysiology in non-amniote vertebrates.

关键词： grass carp reovirus(GCRV)-induced gene 2 lineage-specific expansion gene duplication phylogenectic tree gene structure

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