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Three kinds of horizon-like hypersurface of a uniformly accelerating, non-stationary charged black hole

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Science China Mathematics 1998年第2期41卷 183-190页

作者：闫荣义蒋亚玲程素君 Department of Physics Nanyang Teachers College Henan China Department of Physics Beijing Normal University Beijing China Department of Physics Xiangyang Teachers College Hubei China Department of Physics Xinxiang Teachers College Henan China

Three kinds of horizon like hypersurface of a uniformly rectilinearly accelerating, non stationary charged black hole: event horizon, apparent horizon and time like limit surface are studied. The result is that the event horizon is apart from the time like limit surface and the apparent horizon in the case where the black hole is charged, uniformly accelerating and its mass is varying (evaporating and accreting). Some other new results are also given.

关键词： non stationary charged black hole event horizon time like limit surface apparent horizon.

Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution

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World Journal of Gastroenterology 2010年第45期16卷 5693-5700页

作者： Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau Experimental Hepatic Ischemia-Reperfusion Unit Institut d'Investigacions Biomèdiques de BarcelonaConsejo Superior de Investigaciones Científicas08036 BarcelonaSpain Unitat de Transplantament de Fetgei Viabilitat del' Empelt Institut d'Investigacions Biomèdiques August Pii Sunyer08036 BarcelonaSpain Laboratory of Human Physiology Faculty of PharmacyUniversity of Monastir5000 MonastirTunisia Unit of Hepatic Transplantation Edouard Herriot Hospital69003 LyonFrance Biomedical Research Center Esther Koplowitz CIBER-ehdInstitute of Health Carlos Ⅲ08036 BarcelonaSpain

AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1  solution supplemented with or without IGF-1 and then perfused "ex vivo " for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein ***: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also ***: IGL-1  enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion.

关键词： AKT Institut georges lopez-1 solution Insulin like growth factor-1 Ischemia reperfusion injury Nitric oxide Oxidative stress Steatotic graft preservation

A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers

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World Journal of Gastroenterology 2010年第46期16卷 5779-5789页

作者： Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University Department of Internal Medicine Sapporo Shirakabadai Hospital Vanderbilt-Ingram Cancer Center and Departments of Medicine and Cell Biology Vanderbilt University

Advances in molecular research in cancer have brought new therapeutic strategies into clinical *** new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) *** concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new *** I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human *** this review,we focus on this promising therapeutic target,*** IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI *** studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer *** results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and *** also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical *** mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single *** summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug ***,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcino

关键词： Dominant negative Gastrointestinal cancer Insulin like growth factor-I receptor Monoclonal anti-body Tyrosine kinase inhibitor

Pressure Gradient Force,Saffman Lift,and Magnus Lift on the Fiber-like Particle in Fluid

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Journal of China Textile University(English Edition) 2000年第2期17卷 23-27页

作者：朱泽飞林建忠 Zhejiang Inst of Science and Technology Hangzhou China

Flher-like particle suspensions are common in both na-ture and industry, but there is little work reported on *** forces acting on the fiber - like particle in fluid arestudied in this paper, and the Magnus lift, Saffman lift,pressure gradient force, and then the dynamics modelhave been received. The numerical study of the simpleshear flow past the cylinders shows that the particles ’motion is controlled by the vortex.

关键词： multi - phase fluid fiber - like particle force analysis

Vestigial like family member 3 is a novel prognostic biomarker for gastric cancer

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World Journal of Clinical Cases 2019年第15期7卷 1954-1963页

作者： Li-Hua Zhang Zhuo Wang Long-Hai Li Yan-Kui Liu Lin-Fang Jin Xiao-Wei Qi Chun Zhang Teng Wang Dong Hua School of Pharmaceutical Sciences Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina Department of Geriatrics Affiliated Wuxi First People's Hospital of Nanjing Medical UniversityWuxi 214122Jiangsu ProvinceChina Wuxi Medical College Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Pathology Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND Vestigial like family member 3(VGLL3)is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma,but its role in gastric cancer(GC)is *** To explore the expression pattern and clinical significance of VGLL3 in *** Integrative analysis was performed on the GC transcriptome profiles and survival information deposited in the ONCOMINE,GEPIA,and ONCOLNC *** expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot,*** addition,the in situ expression of VGLL3 in the GC tissues was determined by immunohistochemistry(IHC),and the patients were accordingly classified into the high and low expression *** correlation of VGLL3 expression status with patient prognosis was then determined by univariate and multivariate Cox regression *** Analysis of the ONCOMINE and GEPIA databases showed that VGLL3 was significantly up-regulated in GC tissues(P=0.003),and associated with the tumor TNM stage(P=0.0163).The high VGLL3 expression group had a significantly worse prognosis compared to the low expression group,as per both GEPIA(P=0.0057)and ONCOLNC(P=0.01).The bioinformatics results were validated by the significantly higher VGLL3 mRNA and protein levels in the GC tissues compared to the adjacent normal tissues(P<0.001)in a cohort of 30 GC ***,high in situ expression of VGLL3 protein was associated with more advanced N and TNM stages and HER2 mutation(P<0.05)in a cohort of 172 ***-Meier analysis showed that the high VGLL3 expression group had a worse prognosis compared to the low expression group(P=0.019).Multivariate analysis showed that VGLL3 expression status was an independent risk factor for *** addition,the prognostic risk model nomogram showed that VGLL3 was the most important indicator,with an area under the receiver operating character

关键词： Vestigial like family member 3 Stomach adenocarcinoma HER2 mutation Gastric cancer Bioinformatics analysis

Protective potential of glucagon like peptide 2(GLP-2) against the neurodegeneration

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Neural Regeneration Research 2019年第11期14卷 1901-1902页

作者： Antonella Amato Flavia Mulè Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF) Università di Palermo

Neurodegeneration consists in loss of neuron specific types, pattern and distribution, leading to progressive dysfunctions of the central nervous system. Neurodegenerative diseases include diverse pathological conditions, among which Alzheimer’s and Parkinson’s diseases are the most prevalent ones. Alzheimer’s disease is known as a growing dementia, characterized by progressive language, memory, and cognitive loss, while Parkinson’s disease is primarily characterized as a motor disorder. Senile plaques, caused by amyloid β peptide, hyperphosphorylated taubased neurofibrillary tangles and synapse loss, are the principal pathological hallmarks of Alzheimer’s disease.

关键词： Protective potential glucagon like peptide 2(GLP-2) neurodegeneration

Preparation of Silk-like PET Microfilament and Its Properties

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Journal of China Textile University(English Edition) 2000年第1期17卷 64-67页

作者：胡祖明刘兆峰吴承训

The polyester microfilament was prepared by means ofnormal fully drawn yarn(FDY)*** effectof water content in chips,the molecular weight of thechips,the jet stretch ratio and the lateral blow on thespinnability and the finest titre of filament that could bereach were *** convenient conditions,thefiber with linear density of about 1.4 dtex could be *** means of wide angle X-ray diffractometer(WAXD),differential scanning calorimeter(DSC)andInstrontester,the structure and properties of the mi-crofilament were discussed.

关键词： polyester fiber silk - like microfilament prcparation.

MOLECULAR DYNAMICS SIMULATIONS OF FILLED AND EMPTY CAGE-like WATER CLUSTERS IN LIQUID WATER AND THEIR SIGNIFICANCE TO GAS HYDRATE FORMATION MECHANISMS

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化工学报 2003年第Z1期54卷 62-66页

作者： GUO Guangjun,ZHANG Yigang and ZHAO Yajuan Institute of Geology and Geophysics,Chinese Academy of sciences Beijing 100029,Chinese Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

Molecular dynamics simulations are performed to observe the evolutions of 512 and 51262 cage-like water clusters filled with or without a methane molecule immersed in bulk liquid water at 250 K and 230 K. The lifetimes of these clusters are calculated according to their Lindemann index δ (t) using the criteria of δ≥0.07. For both the filled and empty clusters, we find the dynamics of bulk water determines the lifetimes of cage-like water clusters, and that the lifetime of 512 62 cage-like cluster is the same as that of 512 cage-like cluster. Although the methane molecule indeed makes the filled cage-like cluster more stable than the empty one, the empty cage-like cluster still has chance to be long-lived compared with the filled clusters. These observations support the labile cluster hypothesis on the formation mechanisms of gas hydrates.

关键词： like in time that were MOLECULAR DYNAMICS SIMULATIONS OF FILLED AND EMPTY CAGE-like WATER CLUSTERS IN LIQUID WATER AND THEIR SIGNIFICANCE TO GAS HYDRATE FORMATION MECHANISMS of cage GAS

CRYSTAL　STRUCTURE　OF　A　2D　SHEET－like　μ－CYANIDO－OXAMIDATO　BRIDGED　Fe（III）－Cu（II）　HETERNUCLEAR　COMPLEX

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Chinese Chemical Letters 1994年第8期5卷 713-714页

作者： Nei Fang Wu Zhong Ning CHEN Jun QIU and Wen Xia TANG (State Key Laboratory of Coordination Chemistry,Nanjing University, Manjing 210093)Jing Ling WANG and Fang Ming NIAO(Department of Chemistry, Tianjin Normal University, Tianjin 300074)

The synthesis is and crystal structure are reported for the sheet-like compourd [CU2(oxpn)Fe(CN )5(NO)]. there oxpn is the dianion of M, M'-bis(3-aminopropyl)oxamide. This compound crustallizes in the orthogonal space group Puma. with a=11 .413(4), b=22.242(5), c=7.736(2) A, and Z=*** structure was refined to conventionat discrepancy factors R=0.047 and Pw=0.054. The Cu(II ) and Fe(III)centers are bridged by oxpn and cyanide, the formal behaves as a his-terdentate tigand bound to cooper(II)ion to form (II) dimers. whereas the latter bridges Cu(II) and Fe(III) centers in both symmetric and asymetric end- to-end bis-monodentate fashions, spreading out along be plane to form a 20 network. The Structure is made up of CuFe unit with Cu(II) and Fe(III) ions locating in a distorted square-based pyramid and a compressed octahedron, respectively.

关键词： III OXAMIDATO COMPLEX CRYSTAL CYANIDO HETERNUCLEAR II like OF BRIDGED Fe Cu