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Construct validity of two animal models of state anxiety in Kunming mice:open field test and light/dark box

Construct validity of two animal models of state anxiety in ...

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中国药理学会第十一次全国学术会议

作者： SUN Peng~1,SUN Shi-guang~2,WEI Sheng~1 (1.Key Laboratory of the Classical Theory of Traditional Chinese Medicine of Ministry of Education,Shandong University of Traditional Chinese Medicine,Jinan 250355,China 2.Brain Behavioral Analysis Laboratory,Department of Pharmacy,Second Affiliated Hospita of Shandong University of Traditional Chinese Medicine/Shandong Provincial Hospital of Integrated Medicine,Jinan 250001,China)

OBJECTIVE To explore the correlation of open field test(OFT) and light/dark box(LDB),as two animal models of state anxiety in Kunming *** The behavior of adult,male,Kunming mice in OFT and LDB was recorded by sequence, for five minutes,with a one-week inter-trial *** following parameters were evaluated:percentage of time exploring in the OFT central area(OFTtime%);percentage of squares crossing in the OFT central area(OFTcross%);total number of squares crossing in OFT(OFTross);total number of rears in the OFT(OFTear);number of fecal boli in OFT(OFTB);percentage of time exploring in the LDB light area(LDB Ltime%);percentage of squares crossing in the LDB light area(LDB Lcross%);and percentage of rears in the LDB light area(LDBrear%);transitions between two areas in LDB(LDBransition);total number of squares crossing in LDB(LDBross);total number of rears in LDB(LDBear);number of fecal boli in LDB(LDB B).Subsequently,factor analysis,cluster analysis and correlation analysis were calculated for these ***①Factor analysis and cluster analysis of variances from either OFT or LDB revealed a three-dimension structure:OFT/LDB-anxiety factor (loaded by OFTtime%,OFTcross%or LDBtime%,LDBcross%,LDBrear%),OFT/LDB-activity factor(loaded by OFTross,OFTear or LDBransition,LDBross,LDBear) and OFT/LDB-emotionality factor(loaded by OFTB or LDBFB).While all the variances from both OFT and LDB in combination were analyzed,it could be seen as five components:DB-anxiety factor(loaded by LDBtime%,LDBcross%and LDBrear%),FT-anxiety factor(loaded by OFTtime%and OFTCcross%),DB-activity factor(loaded by LDBransition,LDBross and LDBear),motionality factor(loaded by OFTB and LDBB) and FT-activity factor(loaded by OFTross and OFTear).②Correlation analysis displayed good correlations between OFT-emotionality factor and LDB-emotionality factor(Pearson =0.383,P<0.001),as same as LDB-anxiety factor and DB-anxiety factor(Pearson = 0.989,P<0.001),OFT-anxiety factor and FT-a

关键词： open field test light/dark box state anxiety animal model factor analysis cluster analysis construct validit

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The anxiolytic effects of Bai Le Mian capsule,a patent traditional Chinese medicine

The anxiolytic effects of Bai Le Mian capsule,a patent tradi...

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中国睡眠研究会第十届全国学术年会

作者： Tian-Xiao Wang Yu-Er Wu Shi-Yu Jiang Huan-Xin Sun Qi Sha Peng Zhao Yin-Ping Wang Hao Wang Wei-Min Qu Zhi-Li Huang Department of Pharmacology School of Basic Medical SciencesFudan University Yangtze River Pharmaceutical Group

Bai Le Mian capsule（BLMC） which is composed of fifteen kinds of traditional Chinese Medicine,Lilium Brownii,Acanthopanax Senticosus,Polygonum Multiflorum,Albizia Julibrissin,etc,is a popular traditional Chinese patent medicine for the treatment of insomnia with potential effect on *** the present study,The effects of acute and chronic effects of BLMC（81,162,325 mg/kg,ig） on antianxiety was tested in the elevated plus maze,open field,and light/dark box,in normal mice and an anxious model using Meta-chlorophenyl-piperazine（mCPP）,a compound with known anxiogenic *** 1 mg/kg was used as reference *** administered BLMC *** 325 mg/kg prolonged the time spent in central area 1.1-fold,and two-week medication,the time spent in central area,open arms area and light box were increased by 2.8-2.0-and 1.7-fold,respectively,compared with vehicle control in normal ***,in anxious model,Acute treatment of BLMC（325 mg/kg） mice spent notably more time in the open arms area 2.1-fold,andconsecutive administration for two weeks,BLMC（325 mg/kg） increased the time spent in central area,open area and light box by 1.6-,2.3-,2.1-fold,respectively,compared with vehicle ***,BLMC（162 mg/kg） also increased the time of light box 2.1-fold in mCPP anxious mice *** study showed that mCPP increased c-Fos expression in the neurons of central nucleus of the amygdala and bed nucleus of stria terminalis by 57% and 60%,respectively,which could be reversed by *** together,these results indicate that BLMC is an effective treatment for anxiety in mice and may in patients.

关键词： Bai Le Mian capsule Anxiolytic Open field Elevated plus maze light/dark box Anxious model

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