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Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Advances in Biological Chemistry 2020年第3期10卷 86-98页

作者： Moraes Fabricio Tarso Galvão Anderson Dourado Fortaleza Dário Batista Amorin Kelly Aparecida da Encarnação Sousa Claudia Cristina Honorio-França Adenilda Cristina França Eduardo Luzia Costa Daniel Tizo Santos Wagner Batista Institute of Exact Sciences and Earth Federal University of Mato Grosso Barra do Garcas/MT Brazil Institute of Biological and Health Sciences Federal University of Mato Grosso Barra do Garcas/MT Brazil UniRv-University of Rio Verde Rio Verde/Go Brazil

To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl4(bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru+3 with bipy and L-trip. The spectroscopic characterization in the middle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl2(bipy)(L-trip)]1/2H2O. Evaluation of then> antitumor potential of precursor K[RuCl4(bipy)] showed the toxic effects on MCF-7 cell line, but n>did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl2n style="font-family:Verdana;">(bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.

关键词： Ruthenium Compounds Pyridine ligands Antitumor Activity Tryptophan Amino Acid MCF-7 Cells ligand n-heterocyclic

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